The Paradigm of G Protein Receptor Transactivation: A Mechanistic Definition and Novel Example
Seven transmembrane G protein—coupled receptors are among the most common in biology and they transduce cellular signals from a plethora of hormones. As well as their own well-characterized signaling pathways, they can also transactivate tyrosine kinase growth factor receptors to greatly expand thei...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/tsw.2011.75 |
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| _version_ | 1849404633885179904 |
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| author | Peter J. Little Micah L. Burch Sefaa Al-aryahi Wenhua Zheng |
| author_facet | Peter J. Little Micah L. Burch Sefaa Al-aryahi Wenhua Zheng |
| author_sort | Peter J. Little |
| collection | DOAJ |
| description | Seven transmembrane G protein—coupled receptors are among the most common in biology and they transduce cellular signals from a plethora of hormones. As well as their own well-characterized signaling pathways, they can also transactivate tyrosine kinase growth factor receptors to greatly expand their own cellular repertoire of responses. Recent data in vascular smooth muscle cells have expanded the breadth of transactivation to include serine/threonine kinase receptors, specifically the receptor for transforming growth factor beta (TGF-β). Stimulation with endothelin and thrombin leads to the rapid formation of C-terminal phosphorylated Smad2, which is the immediate product of activation of the TGF-β receptor. Additionally, it appears that no definition of transactivation based on mechanism is available, so we have provided a definition involving temporal aspects and the absence of de novo protein synthesis. The phenomenon of transactivation is an important biochemical mechanism and potential drug target in multiple diseases. |
| format | Article |
| id | doaj-art-9a4e074e3f0547318a607f931f7d7e90 |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-9a4e074e3f0547318a607f931f7d7e902025-08-20T03:36:54ZengWileyThe Scientific World Journal1537-744X2011-01-011170971410.1100/tsw.2011.75The Paradigm of G Protein Receptor Transactivation: A Mechanistic Definition and Novel ExamplePeter J. Little0Micah L. Burch1Sefaa Al-aryahi2Wenhua Zheng3Discipline of Pharmacy, School of Medical Sciences, RMIT University, Melbourne, Victoria, AustraliaDiabetes and Cell Biology Laboratory, BakerIDI Heart and Diabetes Institute, Melbourne, Victoria, AustraliaDiabetes Complications Group, Health Innovations Research Institute, RMIT University, Melbourne, Victoria, AustraliaNeuropharmacology, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, Guangdong, ChinaSeven transmembrane G protein—coupled receptors are among the most common in biology and they transduce cellular signals from a plethora of hormones. As well as their own well-characterized signaling pathways, they can also transactivate tyrosine kinase growth factor receptors to greatly expand their own cellular repertoire of responses. Recent data in vascular smooth muscle cells have expanded the breadth of transactivation to include serine/threonine kinase receptors, specifically the receptor for transforming growth factor beta (TGF-β). Stimulation with endothelin and thrombin leads to the rapid formation of C-terminal phosphorylated Smad2, which is the immediate product of activation of the TGF-β receptor. Additionally, it appears that no definition of transactivation based on mechanism is available, so we have provided a definition involving temporal aspects and the absence of de novo protein synthesis. The phenomenon of transactivation is an important biochemical mechanism and potential drug target in multiple diseases.http://dx.doi.org/10.1100/tsw.2011.75 |
| spellingShingle | Peter J. Little Micah L. Burch Sefaa Al-aryahi Wenhua Zheng The Paradigm of G Protein Receptor Transactivation: A Mechanistic Definition and Novel Example The Scientific World Journal |
| title | The Paradigm of G Protein Receptor Transactivation: A Mechanistic Definition and Novel Example |
| title_full | The Paradigm of G Protein Receptor Transactivation: A Mechanistic Definition and Novel Example |
| title_fullStr | The Paradigm of G Protein Receptor Transactivation: A Mechanistic Definition and Novel Example |
| title_full_unstemmed | The Paradigm of G Protein Receptor Transactivation: A Mechanistic Definition and Novel Example |
| title_short | The Paradigm of G Protein Receptor Transactivation: A Mechanistic Definition and Novel Example |
| title_sort | paradigm of g protein receptor transactivation a mechanistic definition and novel example |
| url | http://dx.doi.org/10.1100/tsw.2011.75 |
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