Extended-Spectrum Beta-Lactamases
The definition of extended-spectrum beta-lactamases (ESBLs) has expanded rapidly, in terms of both the number and the variety of enzymes. Bacteria bearing plasmidic ESBLs are spreading widely throughout the world. In Canada, the problem has grown less rapidly than in other parts of the world; howeve...
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| Main Author: | |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2006-01-01
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| Series: | Canadian Journal of Infectious Diseases and Medical Microbiology |
| Online Access: | http://dx.doi.org/10.1155/2006/726808 |
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| Summary: | The definition of extended-spectrum beta-lactamases (ESBLs) has
expanded rapidly, in terms of both the number and the variety of
enzymes. Bacteria bearing plasmidic ESBLs are spreading widely
throughout the world. In Canada, the problem has grown less rapidly
than in other parts of the world; however, ESBLs still present a significant
impediment to the treatment of serious infections with extendedspectrum
cephalosporins and penicillins. Although SHV-derived
enzymes were the primary concern in the late 1980s and early 1990s,
these enzymes have been rapidly overtaken by the CTX-M family of
ESBLs. There is no reason to believe that the problem of ESBLs will
not expand rapidly in the face of intense antimicrobial pressure and
lapses in infection control practices. Control should focus on early
detection, accurate characterization, effective treatment and measures
to prevent further spread. |
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| ISSN: | 1712-9532 |