Diverse neuronal activity patterns contribute to the control of distraction in the prefrontal and parietal cortex.
Goal-directed behavior requires the effective suppression of distractions to focus on the task at hand. Although experimental evidence suggests that brain areas in the prefrontal and parietal lobe contribute to the selection of task-relevant and the suppression of task-irrelevant stimuli, how conspi...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2025-01-01
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| Series: | PLoS Biology |
| Online Access: | https://doi.org/10.1371/journal.pbio.3003008 |
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| author | Panagiotis Sapountzis Alexandra Antoniadou Georgia G Gregoriou |
| author_facet | Panagiotis Sapountzis Alexandra Antoniadou Georgia G Gregoriou |
| author_sort | Panagiotis Sapountzis |
| collection | DOAJ |
| description | Goal-directed behavior requires the effective suppression of distractions to focus on the task at hand. Although experimental evidence suggests that brain areas in the prefrontal and parietal lobe contribute to the selection of task-relevant and the suppression of task-irrelevant stimuli, how conspicuous distractors are encoded and effectively ignored remains poorly understood. We recorded neuronal responses from 2 regions in the prefrontal and parietal cortex of macaques, the frontal eye field (FEF) and the lateral intraparietal (LIP) area, during a visual search task, in the presence and absence of a salient distractor. We found that in both areas, salient distractors are encoded by both response enhancement and suppression by distinct neuronal populations. In FEF, a larger proportion of units displayed suppression of responses to the salient distractor compared to LIP, with suppression effects in FEF being correlated with search time. Moreover, in FEF but not in LIP, the suppression for the salient distractor compared to non-salient distractors that shared the target color could not be accounted for by an enhancement of target features. These results reveal a distinct contribution of FEF in the suppression of salient distractors. Critically, we found that in both areas, the population level representations of the target and singleton locations were not orthogonal, suggesting a mechanism of interference from salient stimuli. |
| format | Article |
| id | doaj-art-9a435048185c4bde9ac4aef320a4db8e |
| institution | Kabale University |
| issn | 1544-9173 1545-7885 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Biology |
| spelling | doaj-art-9a435048185c4bde9ac4aef320a4db8e2025-02-12T05:30:24ZengPublic Library of Science (PLoS)PLoS Biology1544-91731545-78852025-01-01231e300300810.1371/journal.pbio.3003008Diverse neuronal activity patterns contribute to the control of distraction in the prefrontal and parietal cortex.Panagiotis SapountzisAlexandra AntoniadouGeorgia G GregoriouGoal-directed behavior requires the effective suppression of distractions to focus on the task at hand. Although experimental evidence suggests that brain areas in the prefrontal and parietal lobe contribute to the selection of task-relevant and the suppression of task-irrelevant stimuli, how conspicuous distractors are encoded and effectively ignored remains poorly understood. We recorded neuronal responses from 2 regions in the prefrontal and parietal cortex of macaques, the frontal eye field (FEF) and the lateral intraparietal (LIP) area, during a visual search task, in the presence and absence of a salient distractor. We found that in both areas, salient distractors are encoded by both response enhancement and suppression by distinct neuronal populations. In FEF, a larger proportion of units displayed suppression of responses to the salient distractor compared to LIP, with suppression effects in FEF being correlated with search time. Moreover, in FEF but not in LIP, the suppression for the salient distractor compared to non-salient distractors that shared the target color could not be accounted for by an enhancement of target features. These results reveal a distinct contribution of FEF in the suppression of salient distractors. Critically, we found that in both areas, the population level representations of the target and singleton locations were not orthogonal, suggesting a mechanism of interference from salient stimuli.https://doi.org/10.1371/journal.pbio.3003008 |
| spellingShingle | Panagiotis Sapountzis Alexandra Antoniadou Georgia G Gregoriou Diverse neuronal activity patterns contribute to the control of distraction in the prefrontal and parietal cortex. PLoS Biology |
| title | Diverse neuronal activity patterns contribute to the control of distraction in the prefrontal and parietal cortex. |
| title_full | Diverse neuronal activity patterns contribute to the control of distraction in the prefrontal and parietal cortex. |
| title_fullStr | Diverse neuronal activity patterns contribute to the control of distraction in the prefrontal and parietal cortex. |
| title_full_unstemmed | Diverse neuronal activity patterns contribute to the control of distraction in the prefrontal and parietal cortex. |
| title_short | Diverse neuronal activity patterns contribute to the control of distraction in the prefrontal and parietal cortex. |
| title_sort | diverse neuronal activity patterns contribute to the control of distraction in the prefrontal and parietal cortex |
| url | https://doi.org/10.1371/journal.pbio.3003008 |
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