U-shaped association between serum chloride and hypertension risk with nadir around 103 mmol/L: insights from regression and interpretable machine learning (XGBoost/SHAP) using NHANES 2017-2018

U-shaped association between serum chloride and hypertension risk with nadir around 103 mmol/L: insights from regression and interpretable machine learning (XGBoost/SHAP) using NHANES 2017-2018

BackgroundHypertension is a major contributing factor for cardiovascular disease. This research attempted to explicate the link between serum levels of chloride and the risk of hypertension occurrence, as well as to identify the threshold level at which the risk undergoes changes across the general...

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Bibliographic Details
Main Authors: Shancheng He, Xuemei Zhong, Guangming Chen, Long Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Physiology
Subjects:
serum chloride
NHANES
hypertension
multiple regression analysis
smooth curve fitting
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2025.1612895/full
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