Evaluation of non-motor symptoms in Parkinson’s disease using multiparametric MRI with the multiplex sequence

Evaluation of non-motor symptoms in Parkinson’s disease using multiparametric MRI with the multiplex sequence

BackgroundNon-motor symptoms (NMS) in Parkinson’s disease (PD) often precede motor manifestations and are challenging to detect with conventional MRI. This study investigates the use of the Multi-Flip-Angle and Multi-Echo Gradient Echo Sequence (MULTIPLEX) in MRI to detect previously undetectable mi...

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Bibliographic Details
Main Authors: He Sui, Zhanhao Mo, Feng Shi, Qing Zhou, Dan Yu, Jiaqi Wang, Lin Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Aging Neuroscience
Subjects:
Parkinson’s disease
non-motor symptoms
quantitative MRI analysis
brain segmentation
early diagnosis
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2025.1602245/full
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