Exploring the relationship between experience of vaccine adverse events and vaccine hesitancy: A scoping review
Fear of side effects is the main motive for vaccine refusal. However, before the COVID-19 pandemic, little attention had been paid to the actual experience of adverse events and its relationship with vaccine hesitancy. This scoping review aimed to analyze the impact of VH on EAE and vice versa. We r...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2025-12-01
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| Series: | Human Vaccines & Immunotherapeutics |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/21645515.2025.2471225 |
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| author | Fátima Gauna Jocelyn Raude Charles Khouri Jean-Luc Cracowski Jeremy K Ward |
| author_facet | Fátima Gauna Jocelyn Raude Charles Khouri Jean-Luc Cracowski Jeremy K Ward |
| author_sort | Fátima Gauna |
| collection | DOAJ |
| description | Fear of side effects is the main motive for vaccine refusal. However, before the COVID-19 pandemic, little attention had been paid to the actual experience of adverse events and its relationship with vaccine hesitancy. This scoping review aimed to analyze the impact of VH on EAE and vice versa. We reviewed 55 articles. Most of the studies focused on COVID-19 vaccination and employed cross-sectional surveys with self-reported indicators. These studies identified significant correlations between EAE and VH. Social cognitive models shed some light on the influence of EAE on VH, while the converse is usually explained by the nocebo effect that predominately accounts for the converse. This emerging research field is hampered by significant inconsistencies in theoretical explanations, assessments of the relationship, and measurements of these two phenomena. A more comprehensive consideration of individual experience, both objective and subjective, would help develop more effective vaccine communication strategies and improve pharmacological surveillance. |
| format | Article |
| id | doaj-art-9a2f276892f34ed3b046bc948aa0bb4a |
| institution | DOAJ |
| issn | 2164-5515 2164-554X |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Human Vaccines & Immunotherapeutics |
| spelling | doaj-art-9a2f276892f34ed3b046bc948aa0bb4a2025-08-20T03:05:22ZengTaylor & Francis GroupHuman Vaccines & Immunotherapeutics2164-55152164-554X2025-12-0121110.1080/21645515.2025.2471225Exploring the relationship between experience of vaccine adverse events and vaccine hesitancy: A scoping reviewFátima Gauna0Jocelyn Raude1Charles Khouri2Jean-Luc Cracowski3Jeremy K Ward4CERMES3, (INSERM, CNRS, EHESS) Université de Paris, Villejuif, FranceEHESP, CNRS, Inserm, Arènes - UMR 6051, RSMS (Recherche sur les Services et Management en Santé) - U 1309, Université de Rennes, Rennes, FranceUniversité Grenoble Alpes, Pharmacovigilance Unit, Grenoble Alpes University Hospital, Grenoble, FranceUniversité Grenoble Alpes, Pharmacovigilance Unit, Grenoble Alpes University Hospital, Grenoble, FranceCERMES3, (INSERM, CNRS, EHESS) Université de Paris, Villejuif, FranceFear of side effects is the main motive for vaccine refusal. However, before the COVID-19 pandemic, little attention had been paid to the actual experience of adverse events and its relationship with vaccine hesitancy. This scoping review aimed to analyze the impact of VH on EAE and vice versa. We reviewed 55 articles. Most of the studies focused on COVID-19 vaccination and employed cross-sectional surveys with self-reported indicators. These studies identified significant correlations between EAE and VH. Social cognitive models shed some light on the influence of EAE on VH, while the converse is usually explained by the nocebo effect that predominately accounts for the converse. This emerging research field is hampered by significant inconsistencies in theoretical explanations, assessments of the relationship, and measurements of these two phenomena. A more comprehensive consideration of individual experience, both objective and subjective, would help develop more effective vaccine communication strategies and improve pharmacological surveillance.https://www.tandfonline.com/doi/10.1080/21645515.2025.2471225Personal experienceadverse eventsvaccine hesitancyvaccinationpharmacosurveillance |
| spellingShingle | Fátima Gauna Jocelyn Raude Charles Khouri Jean-Luc Cracowski Jeremy K Ward Exploring the relationship between experience of vaccine adverse events and vaccine hesitancy: A scoping review Human Vaccines & Immunotherapeutics Personal experience adverse events vaccine hesitancy vaccination pharmacosurveillance |
| title | Exploring the relationship between experience of vaccine adverse events and vaccine hesitancy: A scoping review |
| title_full | Exploring the relationship between experience of vaccine adverse events and vaccine hesitancy: A scoping review |
| title_fullStr | Exploring the relationship between experience of vaccine adverse events and vaccine hesitancy: A scoping review |
| title_full_unstemmed | Exploring the relationship between experience of vaccine adverse events and vaccine hesitancy: A scoping review |
| title_short | Exploring the relationship between experience of vaccine adverse events and vaccine hesitancy: A scoping review |
| title_sort | exploring the relationship between experience of vaccine adverse events and vaccine hesitancy a scoping review |
| topic | Personal experience adverse events vaccine hesitancy vaccination pharmacosurveillance |
| url | https://www.tandfonline.com/doi/10.1080/21645515.2025.2471225 |
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