Targeted hematopoietic stem cell depletion through SCF-blockade

Targeted hematopoietic stem cell depletion through SCF-blockade

Abstract Background Hematopoietic stem cell transplantation (HSCT) is a curative treatment for many diverse blood and immune diseases. However, HSCT regimens currently commonly utilize genotoxic chemotherapy and/or total body irradiation (TBI) conditioning which causes significant morbidity and mort...

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Main Authors: Yan Yi Chan, Pui Yan Ho, Carla Dib, Leah Swartzrock, Maire Rayburn, Hana Willner, Ethan Ko, Katie Ho, Julian D. Down, Adam C. Wilkinson, Hiro Nakauchi, Morgane Denis, Taylor Cool, Agnieszka Czechowicz
Format: Article
Language:English
Published: BMC 2024-10-01
Series:Stem Cell Research & Therapy
Online Access:https://doi.org/10.1186/s13287-024-03981-0
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