Diagnostic Accuracy of Diffusion Weighted Imaging in Differentiating Benign and Malignant Breast Lesions: A Cross-Sectional Study
Objective: To evaluate the role of diffusion-weighted MRI and to identify proper cut-off ADC value to differentiate benign from malignant breast lesions by correlating them with cytology/ histopathology examination. Apparent Diffusion Coefficient (ADC) is the objective measure of diffusion and is u...
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KARACHI MEDICAL AND DENTAL COLLEGE
2024-11-01
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| Series: | Annals of Abbasi Shaheed Hospital and Karachi Medical & Dental College |
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| Online Access: | https://annals-ashkmdc.org/pre_install/1/index.php/ashkmdc/article/view/792 |
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| author | Srestha Khan Senthil Kumar Aiyappan Ragitha Ramesh Shriram Natarajan Ramya Sai Dachepalli Nishant |
| author_facet | Srestha Khan Senthil Kumar Aiyappan Ragitha Ramesh Shriram Natarajan Ramya Sai Dachepalli Nishant |
| author_sort | Srestha Khan |
| collection | DOAJ |
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Objective: To evaluate the role of diffusion-weighted MRI and to identify proper cut-off ADC value to differentiate benign from malignant breast lesions by correlating them with cytology/ histopathology examination. Apparent Diffusion Coefficient (ADC) is the objective measure of diffusion and is usually lower in malignant breast lesions.
Methods: This was prospective cross-sectional research done in the Department of Radiodiagnosis involving 56 patients (with 82 breast lumps involving bilateral breasts). The breast lesions were identified by mammography, palpation, or B Mode ultrasonography. All these patients underwent MRI breast (Diffusion-weighted imaging). ADC mapping was done and ADC values were computed with the b values of 0, 800 & 1000. For every case that had an MRI, a histopathological or cytological confirmation was performed with the patient’s consent. The results of HPE/ cytology were correlated with MRI findings (Table/ Fig 1).
Results: The mean ADC value among Malignant breast lesions has been 0.89 (±0.13) x10-3 mm2/s which is lower by 0.41 and statistically significant (P<0.05) compared to the ADC value of benign lesions which was 1.3 (±0.13) x10-3 mm2/s. The AUC for the value of ADC in predicting malignancy was 0.965 (0.928 - 1). In this investigation, the ADC value cut-off of 1.05 x 10-3 mm2/s has been utilized to predict malignant and benign lesions. This value had a specificity of 93.0%, sensitivity of 92.30%, NPV (negative predictive value) of 93.22%, PPV (positive predictive value) of 92.28%, and accuracy of 92.67%.
Conclusion: ADC value can be used as an efficient tool in the characterization of breast lesions with 1.05 x10-3 mm2/s as the best cut-off value for differentiating malignant tumors.
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| format | Article |
| id | doaj-art-9a25f4dd0bf04205bce8c90106cc94c2 |
| institution | DOAJ |
| issn | 1563-3241 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | KARACHI MEDICAL AND DENTAL COLLEGE |
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| series | Annals of Abbasi Shaheed Hospital and Karachi Medical & Dental College |
| spelling | doaj-art-9a25f4dd0bf04205bce8c90106cc94c22025-08-20T03:12:49ZengKARACHI MEDICAL AND DENTAL COLLEGEAnnals of Abbasi Shaheed Hospital and Karachi Medical & Dental College1563-32412024-11-0129410.58397/ashkmdc.v29i4.792Diagnostic Accuracy of Diffusion Weighted Imaging in Differentiating Benign and Malignant Breast Lesions: A Cross-Sectional StudySrestha Khan0Senthil Kumar Aiyappan1Ragitha Ramesh2Shriram Natarajan3Ramya Sai Dachepalli 4Nishant5SRM Medical college and hospital, Chengalpattu, Tamil NaduSRM Medical college and hospital, Chengalpattu, Tamil NaduSRM medical college hospital and research centreSRM Medical college and hospital, Chengalpattu, Tamil NaduSRM Medical college and hospital, Chengalpattu, Tamil NaduSRM Medical college and hospital, Chengalpattu, Tamil Nadu Objective: To evaluate the role of diffusion-weighted MRI and to identify proper cut-off ADC value to differentiate benign from malignant breast lesions by correlating them with cytology/ histopathology examination. Apparent Diffusion Coefficient (ADC) is the objective measure of diffusion and is usually lower in malignant breast lesions. Methods: This was prospective cross-sectional research done in the Department of Radiodiagnosis involving 56 patients (with 82 breast lumps involving bilateral breasts). The breast lesions were identified by mammography, palpation, or B Mode ultrasonography. All these patients underwent MRI breast (Diffusion-weighted imaging). ADC mapping was done and ADC values were computed with the b values of 0, 800 & 1000. For every case that had an MRI, a histopathological or cytological confirmation was performed with the patient’s consent. The results of HPE/ cytology were correlated with MRI findings (Table/ Fig 1). Results: The mean ADC value among Malignant breast lesions has been 0.89 (±0.13) x10-3 mm2/s which is lower by 0.41 and statistically significant (P<0.05) compared to the ADC value of benign lesions which was 1.3 (±0.13) x10-3 mm2/s. The AUC for the value of ADC in predicting malignancy was 0.965 (0.928 - 1). In this investigation, the ADC value cut-off of 1.05 x 10-3 mm2/s has been utilized to predict malignant and benign lesions. This value had a specificity of 93.0%, sensitivity of 92.30%, NPV (negative predictive value) of 93.22%, PPV (positive predictive value) of 92.28%, and accuracy of 92.67%. Conclusion: ADC value can be used as an efficient tool in the characterization of breast lesions with 1.05 x10-3 mm2/s as the best cut-off value for differentiating malignant tumors. https://annals-ashkmdc.org/pre_install/1/index.php/ashkmdc/article/view/792Breast carcinomaADC,Diffusion Weighted ImagingDWI,Benign breast lesion. |
| spellingShingle | Srestha Khan Senthil Kumar Aiyappan Ragitha Ramesh Shriram Natarajan Ramya Sai Dachepalli Nishant Diagnostic Accuracy of Diffusion Weighted Imaging in Differentiating Benign and Malignant Breast Lesions: A Cross-Sectional Study Annals of Abbasi Shaheed Hospital and Karachi Medical & Dental College Breast carcinoma ADC, Diffusion Weighted Imaging DWI, Benign breast lesion. |
| title | Diagnostic Accuracy of Diffusion Weighted Imaging in Differentiating Benign and Malignant Breast Lesions: A Cross-Sectional Study |
| title_full | Diagnostic Accuracy of Diffusion Weighted Imaging in Differentiating Benign and Malignant Breast Lesions: A Cross-Sectional Study |
| title_fullStr | Diagnostic Accuracy of Diffusion Weighted Imaging in Differentiating Benign and Malignant Breast Lesions: A Cross-Sectional Study |
| title_full_unstemmed | Diagnostic Accuracy of Diffusion Weighted Imaging in Differentiating Benign and Malignant Breast Lesions: A Cross-Sectional Study |
| title_short | Diagnostic Accuracy of Diffusion Weighted Imaging in Differentiating Benign and Malignant Breast Lesions: A Cross-Sectional Study |
| title_sort | diagnostic accuracy of diffusion weighted imaging in differentiating benign and malignant breast lesions a cross sectional study |
| topic | Breast carcinoma ADC, Diffusion Weighted Imaging DWI, Benign breast lesion. |
| url | https://annals-ashkmdc.org/pre_install/1/index.php/ashkmdc/article/view/792 |
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