Recurrent Helicobacter cinaedi bacteremia cured with long-term oral minocycline treatment in a patient undergoing hemodialysis: a case report and literature review
Abstract Background Helicobacter cinaedi is a Gram-negative spiral bacillus that inhabits the intestines of animals. First reported in 1984 as the causative agent of proctitis in a homosexual man, it causes bacteremia, cellulitis, and infections in many organs and tissues, particularly in immunocomp...
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| Format: | Article |
| Language: | English |
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BMC
2025-01-01
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| Series: | Renal Replacement Therapy |
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| Online Access: | https://doi.org/10.1186/s41100-024-00596-2 |
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| author | Yutaka Kakizoe Yasunobu Iwata Terumasa Nakagawa Yoshikazu Miyasato Teruhiko Mizumoto Yuichiro Izumi Takashige Kuwabara Masataka Adachi Hideki Yokoi Masashi Mukoyama |
| author_facet | Yutaka Kakizoe Yasunobu Iwata Terumasa Nakagawa Yoshikazu Miyasato Teruhiko Mizumoto Yuichiro Izumi Takashige Kuwabara Masataka Adachi Hideki Yokoi Masashi Mukoyama |
| author_sort | Yutaka Kakizoe |
| collection | DOAJ |
| description | Abstract Background Helicobacter cinaedi is a Gram-negative spiral bacillus that inhabits the intestines of animals. First reported in 1984 as the causative agent of proctitis in a homosexual man, it causes bacteremia, cellulitis, and infections in many organs and tissues, particularly in immunocompromised patients. The clinical challenge with H. cinaedi infection includes its slow growth rate and weak Gram staining that make it easy to misdiagnose, as well as the high incidence of relapses after the discontinuation of antibiotics. Herein, we report a case of delayed diagnosis of H. cinaedi bacteremia in a patient undergoing hemodialysis, where long-term minocycline therapy proved effective. Case presentation A 59-year-old woman undergoing maintenance hemodialysis for lupus nephritis presented with a high fever. She was thought to have a bacterial infection and was initially treated with tazobactam/piperacillin, resulting in a good response and discharge. Soon after discharge, the fever recurred, leading to readmission for further evaluation. After admission, polymerase chain reaction and sequencing of the blood culture sample taken during the first admission revealed that she had H. cinaedi bacteremia. The fever promptly subsided with the administration of meropenem. However, long-term antibiotic use was deemed necessary, and oral minocycline therapy was initiated. Minocycline was administered for 12 weeks, leading to complete resolution of infection. Conclusions In cases of recurrent fever following antibiotic treatment, especially in immunocompromised patients, H. cinaedi infection should be considered, warranting appropriate culture testing and antibiotic therapy. Oral minocycline is considered an effective treatment option in such cases. |
| format | Article |
| id | doaj-art-9a1ed3031fe84b2881edfb944d374232 |
| institution | Kabale University |
| issn | 2059-1381 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Renal Replacement Therapy |
| spelling | doaj-art-9a1ed3031fe84b2881edfb944d3742322025-01-05T12:47:10ZengBMCRenal Replacement Therapy2059-13812025-01-011111910.1186/s41100-024-00596-2Recurrent Helicobacter cinaedi bacteremia cured with long-term oral minocycline treatment in a patient undergoing hemodialysis: a case report and literature reviewYutaka Kakizoe0Yasunobu Iwata1Terumasa Nakagawa2Yoshikazu Miyasato3Teruhiko Mizumoto4Yuichiro Izumi5Takashige Kuwabara6Masataka Adachi7Hideki Yokoi8Masashi Mukoyama9Department of Nephrology, Kumamoto University Graduate School of Medical SciencesDepartment of Nephrology, Kumamoto University Graduate School of Medical SciencesDepartment of Nephrology, Kumamoto University Graduate School of Medical SciencesDepartment of Nephrology, Kumamoto University Graduate School of Medical SciencesDepartment of Nephrology, Kumamoto University Graduate School of Medical SciencesDepartment of Nephrology, Kumamoto University Graduate School of Medical SciencesDepartment of Nephrology, Kumamoto University Graduate School of Medical SciencesDepartment of Nephrology, Kumamoto University Graduate School of Medical SciencesDepartment of Nephrology, Kumamoto University Graduate School of Medical SciencesDepartment of Nephrology, Kumamoto University Graduate School of Medical SciencesAbstract Background Helicobacter cinaedi is a Gram-negative spiral bacillus that inhabits the intestines of animals. First reported in 1984 as the causative agent of proctitis in a homosexual man, it causes bacteremia, cellulitis, and infections in many organs and tissues, particularly in immunocompromised patients. The clinical challenge with H. cinaedi infection includes its slow growth rate and weak Gram staining that make it easy to misdiagnose, as well as the high incidence of relapses after the discontinuation of antibiotics. Herein, we report a case of delayed diagnosis of H. cinaedi bacteremia in a patient undergoing hemodialysis, where long-term minocycline therapy proved effective. Case presentation A 59-year-old woman undergoing maintenance hemodialysis for lupus nephritis presented with a high fever. She was thought to have a bacterial infection and was initially treated with tazobactam/piperacillin, resulting in a good response and discharge. Soon after discharge, the fever recurred, leading to readmission for further evaluation. After admission, polymerase chain reaction and sequencing of the blood culture sample taken during the first admission revealed that she had H. cinaedi bacteremia. The fever promptly subsided with the administration of meropenem. However, long-term antibiotic use was deemed necessary, and oral minocycline therapy was initiated. Minocycline was administered for 12 weeks, leading to complete resolution of infection. Conclusions In cases of recurrent fever following antibiotic treatment, especially in immunocompromised patients, H. cinaedi infection should be considered, warranting appropriate culture testing and antibiotic therapy. Oral minocycline is considered an effective treatment option in such cases.https://doi.org/10.1186/s41100-024-00596-2BacteremiaHelicobacter cinaediHemodialysisMinocyclineRecurrent fever |
| spellingShingle | Yutaka Kakizoe Yasunobu Iwata Terumasa Nakagawa Yoshikazu Miyasato Teruhiko Mizumoto Yuichiro Izumi Takashige Kuwabara Masataka Adachi Hideki Yokoi Masashi Mukoyama Recurrent Helicobacter cinaedi bacteremia cured with long-term oral minocycline treatment in a patient undergoing hemodialysis: a case report and literature review Renal Replacement Therapy Bacteremia Helicobacter cinaedi Hemodialysis Minocycline Recurrent fever |
| title | Recurrent Helicobacter cinaedi bacteremia cured with long-term oral minocycline treatment in a patient undergoing hemodialysis: a case report and literature review |
| title_full | Recurrent Helicobacter cinaedi bacteremia cured with long-term oral minocycline treatment in a patient undergoing hemodialysis: a case report and literature review |
| title_fullStr | Recurrent Helicobacter cinaedi bacteremia cured with long-term oral minocycline treatment in a patient undergoing hemodialysis: a case report and literature review |
| title_full_unstemmed | Recurrent Helicobacter cinaedi bacteremia cured with long-term oral minocycline treatment in a patient undergoing hemodialysis: a case report and literature review |
| title_short | Recurrent Helicobacter cinaedi bacteremia cured with long-term oral minocycline treatment in a patient undergoing hemodialysis: a case report and literature review |
| title_sort | recurrent helicobacter cinaedi bacteremia cured with long term oral minocycline treatment in a patient undergoing hemodialysis a case report and literature review |
| topic | Bacteremia Helicobacter cinaedi Hemodialysis Minocycline Recurrent fever |
| url | https://doi.org/10.1186/s41100-024-00596-2 |
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