Expression and prognostic significance of CD93 in blood vessels in colorectal cancer: an immunohistochemical analysis of 134 cases
Abstract Objective Tumor blood vessels are tortuous and dilated, contributing to the aberrant tumor microenvironment. CD93 is a newly reported transmembrane receptor, mainly expressed in tumor endothelial cells, that has demonstrated prognostic value in some cancer types. However, the role of CD93 i...
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| Language: | English |
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BMC
2025-02-01
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| Series: | BMC Gastroenterology |
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| Online Access: | https://doi.org/10.1186/s12876-025-03643-2 |
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| author | Shuzhe Yang Zhongyuan Bai Fei Zhang Wei Cui Peng Bu Wenqi Bai Yanfeng Xi |
| author_facet | Shuzhe Yang Zhongyuan Bai Fei Zhang Wei Cui Peng Bu Wenqi Bai Yanfeng Xi |
| author_sort | Shuzhe Yang |
| collection | DOAJ |
| description | Abstract Objective Tumor blood vessels are tortuous and dilated, contributing to the aberrant tumor microenvironment. CD93 is a newly reported transmembrane receptor, mainly expressed in tumor endothelial cells, that has demonstrated prognostic value in some cancer types. However, the role of CD93 in the vasculature of colorectal cancer (CRC) tissues and its prognostic significance remain unknown. It is therefore necessary to explore the effect of CD93 in patients with CRC. Method We detected the expression of CD93 in human CRC tissues using immunohistochemistry. We then examined the correlation between CD93 expression and clinicopathological factors in cancer tissues from 134 patients with CRC. Result CD93 expression levels were higher in CRC vessels than in vessels in adjacent normal tissues. Upregulation of CD93 was associated with tumor site and microsatellite instability. CD93 protein expression was positively related to macrophage infiltration in CRC. High expression of CD93 may indicate normalization of the tumor vasculature and was associated with better overall survival. Conclusion CD93 was highly expressed in CRC vessels and correlated with infiltration of immune cells. Our findings reveal that vascular normalization and patient prognosis can be predicted by detecting CD93 expression in CRC tumor tissues. |
| format | Article |
| id | doaj-art-9a1ecc99b19946af818c3a77ba43ceb3 |
| institution | OA Journals |
| issn | 1471-230X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Gastroenterology |
| spelling | doaj-art-9a1ecc99b19946af818c3a77ba43ceb32025-08-20T02:15:11ZengBMCBMC Gastroenterology1471-230X2025-02-0125111210.1186/s12876-025-03643-2Expression and prognostic significance of CD93 in blood vessels in colorectal cancer: an immunohistochemical analysis of 134 casesShuzhe Yang0Zhongyuan Bai1Fei Zhang2Wei Cui3Peng Bu4Wenqi Bai5Yanfeng Xi6Second Clinical Medical School, Shanxi Medical UniversityFirst Clinical Medical School, Shanxi Medical UniversityDepartment of Pathology, Shanxi Province Cancer Hospital/ Shanxi Hospital Affiliated to Cancer Hosipital, Chinese Academy of Medical Sciences/ Cancer Hospital Affiliated to Shanxi Medical UniversityDepartment of Pathology, Shanxi Province Cancer Hospital/ Shanxi Hospital Affiliated to Cancer Hosipital, Chinese Academy of Medical Sciences/ Cancer Hospital Affiliated to Shanxi Medical UniversityDepartment of Pathology, Shanxi Province Cancer Hospital/ Shanxi Hospital Affiliated to Cancer Hosipital, Chinese Academy of Medical Sciences/ Cancer Hospital Affiliated to Shanxi Medical UniversityDepartment of General Surgery Sciences, Cancer Hospital, Shanxi Province Cancer Hospital/ShanxiHospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences/Cancer Hospital Affiliated to ShanxiMedical UniversityDepartment of Pathology, Shanxi Province Cancer Hospital/ Shanxi Hospital Affiliated to Cancer Hosipital, Chinese Academy of Medical Sciences/ Cancer Hospital Affiliated to Shanxi Medical UniversityAbstract Objective Tumor blood vessels are tortuous and dilated, contributing to the aberrant tumor microenvironment. CD93 is a newly reported transmembrane receptor, mainly expressed in tumor endothelial cells, that has demonstrated prognostic value in some cancer types. However, the role of CD93 in the vasculature of colorectal cancer (CRC) tissues and its prognostic significance remain unknown. It is therefore necessary to explore the effect of CD93 in patients with CRC. Method We detected the expression of CD93 in human CRC tissues using immunohistochemistry. We then examined the correlation between CD93 expression and clinicopathological factors in cancer tissues from 134 patients with CRC. Result CD93 expression levels were higher in CRC vessels than in vessels in adjacent normal tissues. Upregulation of CD93 was associated with tumor site and microsatellite instability. CD93 protein expression was positively related to macrophage infiltration in CRC. High expression of CD93 may indicate normalization of the tumor vasculature and was associated with better overall survival. Conclusion CD93 was highly expressed in CRC vessels and correlated with infiltration of immune cells. Our findings reveal that vascular normalization and patient prognosis can be predicted by detecting CD93 expression in CRC tumor tissues.https://doi.org/10.1186/s12876-025-03643-2Colorectal cancerCD93Tumor vascular normalizationTumor microenvironment |
| spellingShingle | Shuzhe Yang Zhongyuan Bai Fei Zhang Wei Cui Peng Bu Wenqi Bai Yanfeng Xi Expression and prognostic significance of CD93 in blood vessels in colorectal cancer: an immunohistochemical analysis of 134 cases BMC Gastroenterology Colorectal cancer CD93 Tumor vascular normalization Tumor microenvironment |
| title | Expression and prognostic significance of CD93 in blood vessels in colorectal cancer: an immunohistochemical analysis of 134 cases |
| title_full | Expression and prognostic significance of CD93 in blood vessels in colorectal cancer: an immunohistochemical analysis of 134 cases |
| title_fullStr | Expression and prognostic significance of CD93 in blood vessels in colorectal cancer: an immunohistochemical analysis of 134 cases |
| title_full_unstemmed | Expression and prognostic significance of CD93 in blood vessels in colorectal cancer: an immunohistochemical analysis of 134 cases |
| title_short | Expression and prognostic significance of CD93 in blood vessels in colorectal cancer: an immunohistochemical analysis of 134 cases |
| title_sort | expression and prognostic significance of cd93 in blood vessels in colorectal cancer an immunohistochemical analysis of 134 cases |
| topic | Colorectal cancer CD93 Tumor vascular normalization Tumor microenvironment |
| url | https://doi.org/10.1186/s12876-025-03643-2 |
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