Multiscale investigation of collagen structure in human skin and gel matrices using polarization resolved second harmonic generation microscopy

Abstract Collagen is critical to the structure and function of skin tissues, with the collagen I/III ratios influencing fibrillogenesis, fiber organization, and skin mechanics. Abnormal collagen organization, such as in fibrosis or scar tissue, compromises both skin functionality and aesthetics. In...

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Bibliographic Details
Main Authors: Mengyao Zhou, Madalena Pinto Gomes, Anouk Elgersma, H. Ibrahim Korkmaz, Bouke K. H. L. Boekema, Marie Louise Groot
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:Scientific Reports
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Online Access:https://doi.org/10.1038/s41598-025-02536-4
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