Gender-dependent differences in plasma matrix metalloproteinase-8 elevated in pulmonary tuberculosis.
Tuberculosis (TB) remains a global health pandemic and greater understanding of underlying pathogenesis is required to develop novel therapeutic and diagnostic approaches. Matrix metalloproteinases (MMPs) are emerging as key effectors of tissue destruction in TB but have not been comprehensively stu...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2015-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0117605 |
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| author | Tarangini Sathyamoorthy Gurjinder Sandhu Liku B Tezera Richard Thomas Akul Singhania Christopher H Woelk Borislav D Dimitrov Dan Agranoff Carlton A W Evans Jon S Friedland Paul T Elkington |
| author_facet | Tarangini Sathyamoorthy Gurjinder Sandhu Liku B Tezera Richard Thomas Akul Singhania Christopher H Woelk Borislav D Dimitrov Dan Agranoff Carlton A W Evans Jon S Friedland Paul T Elkington |
| author_sort | Tarangini Sathyamoorthy |
| collection | DOAJ |
| description | Tuberculosis (TB) remains a global health pandemic and greater understanding of underlying pathogenesis is required to develop novel therapeutic and diagnostic approaches. Matrix metalloproteinases (MMPs) are emerging as key effectors of tissue destruction in TB but have not been comprehensively studied in plasma, nor have gender differences been investigated. We measured the plasma concentrations of MMPs in a carefully characterised, prospectively recruited clinical cohort of 380 individuals. The collagenases, MMP-1 and MMP-8, were elevated in plasma of patients with pulmonary TB relative to healthy controls, and MMP-7 (matrilysin) and MMP-9 (gelatinase B) were also increased. MMP-8 was TB-specific (p<0.001), not being elevated in symptomatic controls (symptoms suspicious of TB but active disease excluded). Plasma MMP-8 concentrations inversely correlated with body mass index. Plasma MMP-8 concentration was 1.51-fold higher in males than females with TB (p<0.05) and this difference was not due to greater disease severity in men. Gender-specific analysis of MMPs demonstrated consistent increase in MMP-1 and -8 in TB, but MMP-8 was a better discriminator for TB in men. Plasma collagenases are elevated in pulmonary TB and differ between men and women. Gender must be considered in investigation of TB immunopathology and development of novel diagnostic markers. |
| format | Article |
| id | doaj-art-9a184e70f308453f9f734e7109855b1d |
| institution | OA Journals |
| issn | 1932-6203 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-9a184e70f308453f9f734e7109855b1d2025-08-20T02:22:39ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-01101e011760510.1371/journal.pone.0117605Gender-dependent differences in plasma matrix metalloproteinase-8 elevated in pulmonary tuberculosis.Tarangini SathyamoorthyGurjinder SandhuLiku B TezeraRichard ThomasAkul SinghaniaChristopher H WoelkBorislav D DimitrovDan AgranoffCarlton A W EvansJon S FriedlandPaul T ElkingtonTuberculosis (TB) remains a global health pandemic and greater understanding of underlying pathogenesis is required to develop novel therapeutic and diagnostic approaches. Matrix metalloproteinases (MMPs) are emerging as key effectors of tissue destruction in TB but have not been comprehensively studied in plasma, nor have gender differences been investigated. We measured the plasma concentrations of MMPs in a carefully characterised, prospectively recruited clinical cohort of 380 individuals. The collagenases, MMP-1 and MMP-8, were elevated in plasma of patients with pulmonary TB relative to healthy controls, and MMP-7 (matrilysin) and MMP-9 (gelatinase B) were also increased. MMP-8 was TB-specific (p<0.001), not being elevated in symptomatic controls (symptoms suspicious of TB but active disease excluded). Plasma MMP-8 concentrations inversely correlated with body mass index. Plasma MMP-8 concentration was 1.51-fold higher in males than females with TB (p<0.05) and this difference was not due to greater disease severity in men. Gender-specific analysis of MMPs demonstrated consistent increase in MMP-1 and -8 in TB, but MMP-8 was a better discriminator for TB in men. Plasma collagenases are elevated in pulmonary TB and differ between men and women. Gender must be considered in investigation of TB immunopathology and development of novel diagnostic markers.https://doi.org/10.1371/journal.pone.0117605 |
| spellingShingle | Tarangini Sathyamoorthy Gurjinder Sandhu Liku B Tezera Richard Thomas Akul Singhania Christopher H Woelk Borislav D Dimitrov Dan Agranoff Carlton A W Evans Jon S Friedland Paul T Elkington Gender-dependent differences in plasma matrix metalloproteinase-8 elevated in pulmonary tuberculosis. PLoS ONE |
| title | Gender-dependent differences in plasma matrix metalloproteinase-8 elevated in pulmonary tuberculosis. |
| title_full | Gender-dependent differences in plasma matrix metalloproteinase-8 elevated in pulmonary tuberculosis. |
| title_fullStr | Gender-dependent differences in plasma matrix metalloproteinase-8 elevated in pulmonary tuberculosis. |
| title_full_unstemmed | Gender-dependent differences in plasma matrix metalloproteinase-8 elevated in pulmonary tuberculosis. |
| title_short | Gender-dependent differences in plasma matrix metalloproteinase-8 elevated in pulmonary tuberculosis. |
| title_sort | gender dependent differences in plasma matrix metalloproteinase 8 elevated in pulmonary tuberculosis |
| url | https://doi.org/10.1371/journal.pone.0117605 |
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