Lysine methyltransferase 2D deficiency drives complete response to pembrolizumab in PD-L1-High cholangiocarcinoma: a case report and review of literature

Lysine methyltransferase 2D deficiency drives complete response to pembrolizumab in PD-L1-High cholangiocarcinoma: a case report and review of literature

BackgroundIntrahepatic cholangiocarcinoma (ICC) typically exhibits poor responsiveness to immune checkpoint inhibitors (ICIs) due to its microsatellite-stable (MSS) status and low tumor mutational burden (TMB). Conventional biomarkers like PD-L1 expression show limited predictive value, creating an...

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Bibliographic Details
Main Authors:	Xiaofang Li, Liao Wang, Shuang Li
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-08-01
Series:	Frontiers in Immunology
Subjects:	KMT2D mutations intrahepatic cholangiocarcinoma immune checkpoint therapy predictive biomarkers pathologic complete response
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1616361/full
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