Protective Role of Selenium-Binding Protein 1 (SELENBP1) in Patients with Ulcerative Colitis
Background: The expression of selenium-binding protein 1 (SELENBP1), a molecule responsible for the absorption of selenium in the colon, is crucial for its immunoregulatory effect, but this phenomenon has not been studied in patients with UC. The present study aimed to determine the clinical outcome...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-12-01
|
| Series: | Metabolites |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2218-1989/14/12/662 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850037345299988480 |
|---|---|
| author | Gabriela Fonseca-Camarillo Janette Furuzawa-Carballeda Ángel A. Priego-Ranero Rafael Barreto-Zúñiga Braulio Martínez-Benítez Jesús K. Yamamoto-Furusho |
| author_facet | Gabriela Fonseca-Camarillo Janette Furuzawa-Carballeda Ángel A. Priego-Ranero Rafael Barreto-Zúñiga Braulio Martínez-Benítez Jesús K. Yamamoto-Furusho |
| author_sort | Gabriela Fonseca-Camarillo |
| collection | DOAJ |
| description | Background: The expression of selenium-binding protein 1 (SELENBP1), a molecule responsible for the absorption of selenium in the colon, is crucial for its immunoregulatory effect, but this phenomenon has not been studied in patients with UC. The present study aimed to determine the clinical outcome of SELENBP1 expression in colonic tissue from patients with UC. Methods: The relative mRNA expression of SELENBP1 was analyzed in 34 patients with UC and 20 controls. Statistical analyses were performed with SPSS 19. Results: SELENBP1 gene expression was significantly lower in patients with active UC than those with UC in remission (<i>p</i> = 0.003) and within the controls (<i>p</i> = 0.04). Overexpression of the SELENBP1 gene was associated with a more benign clinical course characterized by initial activity and more than two years of prolonged remission (OR 23.7, <i>p</i> = 0.003) and an intermittent clinical course (OR 47.5, <i>p</i> = 0.001), mild histological activity (OR 0.11; 95% CI: 1.00–1.41, <i>p</i> = 0.05) and severe histological activity (OR 0.08, 95% CI: 0.008–0.866, <i>p</i> = 0.02). SELENBP1-positive cells were found mainly in the submucosa’s inflammatory infiltrate and muscular and adventitia’s internal layers from patients with active UC compared to those in the control group (<i>p</i> ≤ 0.001). Conclusions: The upregulation of SELENBP1 was associated with a benign clinical course of UC. This is the first report suggesting the immunoregulatory role of SELENBP1 in patients with UC. |
| format | Article |
| id | doaj-art-9a17d29bca1349329d4fa590b57ccc56 |
| institution | DOAJ |
| issn | 2218-1989 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Metabolites |
| spelling | doaj-art-9a17d29bca1349329d4fa590b57ccc562025-08-20T02:56:52ZengMDPI AGMetabolites2218-19892024-12-01141266210.3390/metabo14120662Protective Role of Selenium-Binding Protein 1 (SELENBP1) in Patients with Ulcerative ColitisGabriela Fonseca-Camarillo0Janette Furuzawa-Carballeda1Ángel A. Priego-Ranero2Rafael Barreto-Zúñiga3Braulio Martínez-Benítez4Jesús K. Yamamoto-Furusho5Inflammatory Bowel Disease Clinic, Department of Gastroenterology, Instituto Nacional de Ciencias Médicas y Nutrición, Salvador Zubirán, Mexico City 14080, CP, MexicoDepartment of Experimental Surgery, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City 14080, CP, MexicoDepartment of Clinical Cardiology, Instituto Nacional de Cardiología, Ignacio Chávez, Mexico City 14080, CP, MexicoDepartment of Endoscopy, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City 14080, CP, MexicoDepartment of Pathology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City 14080, CP, MexicoInflammatory Bowel Disease Clinic, Department of Gastroenterology, Instituto Nacional de Ciencias Médicas y Nutrición, Salvador Zubirán, Mexico City 14080, CP, MexicoBackground: The expression of selenium-binding protein 1 (SELENBP1), a molecule responsible for the absorption of selenium in the colon, is crucial for its immunoregulatory effect, but this phenomenon has not been studied in patients with UC. The present study aimed to determine the clinical outcome of SELENBP1 expression in colonic tissue from patients with UC. Methods: The relative mRNA expression of SELENBP1 was analyzed in 34 patients with UC and 20 controls. Statistical analyses were performed with SPSS 19. Results: SELENBP1 gene expression was significantly lower in patients with active UC than those with UC in remission (<i>p</i> = 0.003) and within the controls (<i>p</i> = 0.04). Overexpression of the SELENBP1 gene was associated with a more benign clinical course characterized by initial activity and more than two years of prolonged remission (OR 23.7, <i>p</i> = 0.003) and an intermittent clinical course (OR 47.5, <i>p</i> = 0.001), mild histological activity (OR 0.11; 95% CI: 1.00–1.41, <i>p</i> = 0.05) and severe histological activity (OR 0.08, 95% CI: 0.008–0.866, <i>p</i> = 0.02). SELENBP1-positive cells were found mainly in the submucosa’s inflammatory infiltrate and muscular and adventitia’s internal layers from patients with active UC compared to those in the control group (<i>p</i> ≤ 0.001). Conclusions: The upregulation of SELENBP1 was associated with a benign clinical course of UC. This is the first report suggesting the immunoregulatory role of SELENBP1 in patients with UC.https://www.mdpi.com/2218-1989/14/12/662seleniumselenbp1ulcerative colitisremissioninmunoregulationIBD |
| spellingShingle | Gabriela Fonseca-Camarillo Janette Furuzawa-Carballeda Ángel A. Priego-Ranero Rafael Barreto-Zúñiga Braulio Martínez-Benítez Jesús K. Yamamoto-Furusho Protective Role of Selenium-Binding Protein 1 (SELENBP1) in Patients with Ulcerative Colitis Metabolites selenium selenbp1 ulcerative colitis remission inmunoregulation IBD |
| title | Protective Role of Selenium-Binding Protein 1 (SELENBP1) in Patients with Ulcerative Colitis |
| title_full | Protective Role of Selenium-Binding Protein 1 (SELENBP1) in Patients with Ulcerative Colitis |
| title_fullStr | Protective Role of Selenium-Binding Protein 1 (SELENBP1) in Patients with Ulcerative Colitis |
| title_full_unstemmed | Protective Role of Selenium-Binding Protein 1 (SELENBP1) in Patients with Ulcerative Colitis |
| title_short | Protective Role of Selenium-Binding Protein 1 (SELENBP1) in Patients with Ulcerative Colitis |
| title_sort | protective role of selenium binding protein 1 selenbp1 in patients with ulcerative colitis |
| topic | selenium selenbp1 ulcerative colitis remission inmunoregulation IBD |
| url | https://www.mdpi.com/2218-1989/14/12/662 |
| work_keys_str_mv | AT gabrielafonsecacamarillo protectiveroleofseleniumbindingprotein1selenbp1inpatientswithulcerativecolitis AT janettefuruzawacarballeda protectiveroleofseleniumbindingprotein1selenbp1inpatientswithulcerativecolitis AT angelapriegoranero protectiveroleofseleniumbindingprotein1selenbp1inpatientswithulcerativecolitis AT rafaelbarretozuniga protectiveroleofseleniumbindingprotein1selenbp1inpatientswithulcerativecolitis AT brauliomartinezbenitez protectiveroleofseleniumbindingprotein1selenbp1inpatientswithulcerativecolitis AT jesuskyamamotofurusho protectiveroleofseleniumbindingprotein1selenbp1inpatientswithulcerativecolitis |