A network dynamic nomogram for predicting overall survival and cancer-specific survival in patients with breast cancer liver metastases: an analysis based on the SEER database
Abstract The liver stands out as one of the most frequent sites for distant metastasis in breast cancer cases. However, effective risk stratification tools for patients with breast cancer liver metastases (BCLM) are still lacking. We identified BCLM patients from the SEER database spanning from 2010...
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| Format: | Article |
| Language: | English |
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Springer
2024-12-01
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| Series: | Discover Oncology |
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| Online Access: | https://doi.org/10.1007/s12672-024-01719-1 |
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| author | Mengxiang Tian Kangtao Wang Ming Li |
| author_facet | Mengxiang Tian Kangtao Wang Ming Li |
| author_sort | Mengxiang Tian |
| collection | DOAJ |
| description | Abstract The liver stands out as one of the most frequent sites for distant metastasis in breast cancer cases. However, effective risk stratification tools for patients with breast cancer liver metastases (BCLM) are still lacking. We identified BCLM patients from the SEER database spanning from 2010 to 2016. After meticulously filtering out cases with incomplete data, a total of 3179 patients were enrolled and randomly divided into training and validation cohorts at a ratio of 2:1. Leveraging comprehensive patient data, we constructed a nomogram through rigorous evaluation of a Cox regression model. Validation of the nomogram was conducted using a range of statistical measures, including the concordance index (C-index), calibration curves, time-dependent receiver operating characteristic curves, and decision curve analysis (DCA). Both univariable and multivariable analyses revealed significant associations between OS and CSS in BCLM patients and 14 variables, including age, race, and tumor stage, among others. Utilizing these pertinent variables, we formulated nomograms for OS and CSS prediction. Subsequent validation involved rigorous assessment using time-dependent ROC curves, decision curve analysis, C-index evaluations, and calibration curves. Our web-based dynamic nomogram represents a valuable tool for efficiently analyzing the clinical profiles of BCLM patients, thereby aiding in informed clinical decision-making processes. |
| format | Article |
| id | doaj-art-9a120891cb714ebd801f89a8fdc7121a |
| institution | Kabale University |
| issn | 2730-6011 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Springer |
| record_format | Article |
| series | Discover Oncology |
| spelling | doaj-art-9a120891cb714ebd801f89a8fdc7121a2025-01-05T12:34:18ZengSpringerDiscover Oncology2730-60112024-12-0115111410.1007/s12672-024-01719-1A network dynamic nomogram for predicting overall survival and cancer-specific survival in patients with breast cancer liver metastases: an analysis based on the SEER databaseMengxiang Tian0Kangtao Wang1Ming Li2Department of Immunology, College of Basic Medical Sciences, Central South UniversityDepartment of Immunology, College of Basic Medical Sciences, Central South UniversityDepartment of Immunology, College of Basic Medical Sciences, Central South UniversityAbstract The liver stands out as one of the most frequent sites for distant metastasis in breast cancer cases. However, effective risk stratification tools for patients with breast cancer liver metastases (BCLM) are still lacking. We identified BCLM patients from the SEER database spanning from 2010 to 2016. After meticulously filtering out cases with incomplete data, a total of 3179 patients were enrolled and randomly divided into training and validation cohorts at a ratio of 2:1. Leveraging comprehensive patient data, we constructed a nomogram through rigorous evaluation of a Cox regression model. Validation of the nomogram was conducted using a range of statistical measures, including the concordance index (C-index), calibration curves, time-dependent receiver operating characteristic curves, and decision curve analysis (DCA). Both univariable and multivariable analyses revealed significant associations between OS and CSS in BCLM patients and 14 variables, including age, race, and tumor stage, among others. Utilizing these pertinent variables, we formulated nomograms for OS and CSS prediction. Subsequent validation involved rigorous assessment using time-dependent ROC curves, decision curve analysis, C-index evaluations, and calibration curves. Our web-based dynamic nomogram represents a valuable tool for efficiently analyzing the clinical profiles of BCLM patients, thereby aiding in informed clinical decision-making processes.https://doi.org/10.1007/s12672-024-01719-1Breast cancer liver metastases (BCLM)Web-based dynamic nomogramOverall survival (OS)Cancer-specific survival (CSS)SEER database |
| spellingShingle | Mengxiang Tian Kangtao Wang Ming Li A network dynamic nomogram for predicting overall survival and cancer-specific survival in patients with breast cancer liver metastases: an analysis based on the SEER database Discover Oncology Breast cancer liver metastases (BCLM) Web-based dynamic nomogram Overall survival (OS) Cancer-specific survival (CSS) SEER database |
| title | A network dynamic nomogram for predicting overall survival and cancer-specific survival in patients with breast cancer liver metastases: an analysis based on the SEER database |
| title_full | A network dynamic nomogram for predicting overall survival and cancer-specific survival in patients with breast cancer liver metastases: an analysis based on the SEER database |
| title_fullStr | A network dynamic nomogram for predicting overall survival and cancer-specific survival in patients with breast cancer liver metastases: an analysis based on the SEER database |
| title_full_unstemmed | A network dynamic nomogram for predicting overall survival and cancer-specific survival in patients with breast cancer liver metastases: an analysis based on the SEER database |
| title_short | A network dynamic nomogram for predicting overall survival and cancer-specific survival in patients with breast cancer liver metastases: an analysis based on the SEER database |
| title_sort | network dynamic nomogram for predicting overall survival and cancer specific survival in patients with breast cancer liver metastases an analysis based on the seer database |
| topic | Breast cancer liver metastases (BCLM) Web-based dynamic nomogram Overall survival (OS) Cancer-specific survival (CSS) SEER database |
| url | https://doi.org/10.1007/s12672-024-01719-1 |
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