The distribution of four homeobox proteins in the bovine stomach compartments during the fetal period
Homeobox proteins undertake important roles in the determination of the cell identity during embryonic development, the differentiation of embryonic stem cells, morphogenesis, and the formation and development of the mammalian gastrointestinal tract. Based on these data, this study was designed to...
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Universidad del Zulia
2025-04-01
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| Series: | Revista Científica |
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| Online Access: | https://produccioncientificaluz.org/index.php/cientifica/article/view/43747 |
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| author | Uğur Topaloğlu Mehmet Erdem-Akbalık Hakan Sağsöz Muzaffer Aydın-Ketani Berna Güney-Saruhan Nurşin Aydın |
| author_facet | Uğur Topaloğlu Mehmet Erdem-Akbalık Hakan Sağsöz Muzaffer Aydın-Ketani Berna Güney-Saruhan Nurşin Aydın |
| author_sort | Uğur Topaloğlu |
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Homeobox proteins undertake important roles in the determination of the cell identity during embryonic development, the differentiation of embryonic stem cells, morphogenesis, and the formation and development of the mammalian gastrointestinal tract. Based on these data, this study was designed to determine the immunohistochemical localization and expression levels of HOXA10, HOXA11, HOXC6 and HOXB6, which are subunits of the homeobox proteins, in the rumen, reticulum, omasum and abomasum during fetal development. For this purpose, fetuses obtained from private slaughterhouses and were grouped according to their crown-rump length (CRL) measurements, and the gestational trimester they belonged to, as follows: first trimester (69-89 days old/10 fetuses), second trimester (99-178 days old/10 fetuses) and third trimester (188-269 days old/10 fetuses). Gastric tissue samples taken from each group underwent routine histological processing and immunohistochemical staining. Immunohistochemical staining demonstrated that the HOXA10, HOXA11 and HOXC6 proteins were expressed at varying levels in the rumen, reticulum, omasum and abomasum, and their expression was stronger in the epithelial and smooth muscle cells. On the other hand, while there was almost no expression of HOXB6 in the epithelial cells of the rumen during the second and third trimesters of gestation, the remaining gastric components were immunonegative. Based on these findings, it was concluded that some homeobox proteins could have critical roles in the development, morphogenesis and histogenesis of fetal bovine gastric compartments, and thus, could contribute to the lifetime performance and productivity of cattle in terms of milk and meat yields.
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| format | Article |
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| issn | 0798-2259 2521-9715 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Universidad del Zulia |
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| series | Revista Científica |
| spelling | doaj-art-9a0f53b66f6d4736afcb8bb053b60aee2025-08-20T02:25:18ZengUniversidad del ZuliaRevista Científica0798-22592521-97152025-04-0135210.52973/rcfcv-e35586The distribution of four homeobox proteins in the bovine stomach compartments during the fetal periodUğur Topaloğlu0Mehmet Erdem-Akbalık1Hakan Sağsöz2Muzaffer Aydın-Ketani3Berna Güney-Saruhan4Nurşin Aydın5Department of Histology and Embryology, Faculty of Veterinary Medicine, Dicle University, 21280, Diyarbakır, Türkiye.Department of Histology and Embryology, Faculty of Veterinary Medicine, Dicle University, 21280, Diyarbakır, Türkiye.Department of Histology and Embryology, Faculty of Veterinary Medicine, Dicle University, 21280, Diyarbakır, Türkiye.Department of Histology and Embryology, Faculty of Veterinary Medicine, Dicle University, 21280, Diyarbakır, Türkiye.Department of Histology and Embryology, Faculty of Veterinary Medicine, Dicle University, 21280, Diyarbakır, Türkiye.Department of Histology and Embryology, Faculty of Veterinary Medicine, Dicle University, 21280, Diyarbakır, Türkiye. Homeobox proteins undertake important roles in the determination of the cell identity during embryonic development, the differentiation of embryonic stem cells, morphogenesis, and the formation and development of the mammalian gastrointestinal tract. Based on these data, this study was designed to determine the immunohistochemical localization and expression levels of HOXA10, HOXA11, HOXC6 and HOXB6, which are subunits of the homeobox proteins, in the rumen, reticulum, omasum and abomasum during fetal development. For this purpose, fetuses obtained from private slaughterhouses and were grouped according to their crown-rump length (CRL) measurements, and the gestational trimester they belonged to, as follows: first trimester (69-89 days old/10 fetuses), second trimester (99-178 days old/10 fetuses) and third trimester (188-269 days old/10 fetuses). Gastric tissue samples taken from each group underwent routine histological processing and immunohistochemical staining. Immunohistochemical staining demonstrated that the HOXA10, HOXA11 and HOXC6 proteins were expressed at varying levels in the rumen, reticulum, omasum and abomasum, and their expression was stronger in the epithelial and smooth muscle cells. On the other hand, while there was almost no expression of HOXB6 in the epithelial cells of the rumen during the second and third trimesters of gestation, the remaining gastric components were immunonegative. Based on these findings, it was concluded that some homeobox proteins could have critical roles in the development, morphogenesis and histogenesis of fetal bovine gastric compartments, and thus, could contribute to the lifetime performance and productivity of cattle in terms of milk and meat yields. https://produccioncientificaluz.org/index.php/cientifica/article/view/43747bovinefetushomeobox proteinsstomach |
| spellingShingle | Uğur Topaloğlu Mehmet Erdem-Akbalık Hakan Sağsöz Muzaffer Aydın-Ketani Berna Güney-Saruhan Nurşin Aydın The distribution of four homeobox proteins in the bovine stomach compartments during the fetal period Revista Científica bovine fetus homeobox proteins stomach |
| title | The distribution of four homeobox proteins in the bovine stomach compartments during the fetal period |
| title_full | The distribution of four homeobox proteins in the bovine stomach compartments during the fetal period |
| title_fullStr | The distribution of four homeobox proteins in the bovine stomach compartments during the fetal period |
| title_full_unstemmed | The distribution of four homeobox proteins in the bovine stomach compartments during the fetal period |
| title_short | The distribution of four homeobox proteins in the bovine stomach compartments during the fetal period |
| title_sort | distribution of four homeobox proteins in the bovine stomach compartments during the fetal period |
| topic | bovine fetus homeobox proteins stomach |
| url | https://produccioncientificaluz.org/index.php/cientifica/article/view/43747 |
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