Research progress of clozapine-induced myocarditis

Clozapine (CLZ), as a unique and effective atypical antipsychotic drug, has achieved good results in the treatment of schizophrenia, but its cardiotoxicity has attracted the attention of clinicians. Clozapine-induced myocarditis (CIM) is a rare but serious cardiovascular adverse event during the use...

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Main Authors: LI Qianqian, FENG Qian, CHEN Jizong, ZHENG Xin, WANG Weiwei
Format: Article
Language:zho
Published: Editorial Office of Journal of Guangxi Medical University 2024-08-01
Series:Guangxi Yike Daxue xuebao
Subjects:
Online Access:https://journal.gxmu.edu.cn/article/doi/10.16190/j.cnki.45-1211/r.2024.08.016
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author LI Qianqian
FENG Qian
CHEN Jizong
ZHENG Xin
WANG Weiwei
author_facet LI Qianqian
FENG Qian
CHEN Jizong
ZHENG Xin
WANG Weiwei
author_sort LI Qianqian
collection DOAJ
description Clozapine (CLZ), as a unique and effective atypical antipsychotic drug, has achieved good results in the treatment of schizophrenia, but its cardiotoxicity has attracted the attention of clinicians. Clozapine-induced myocarditis (CIM) is a rare but serious cardiovascular adverse event during the use of clozapine, the pathogenesis of which is unknown. The picture is further complicated by considering that people with schizophrenia may have cognitive impairments that make early heart damage difficult to detect. Therefore, this review summarizes the clinical manifestations, auxiliary examination characteristics, risk factors and possible pathogenesis of CIM, providing clues for doctors to diagnose, monitor and treat the CIM.
format Article
id doaj-art-9a0b1ee8881a45b080f668d6370bc2e3
institution OA Journals
issn 1005-930X
language zho
publishDate 2024-08-01
publisher Editorial Office of Journal of Guangxi Medical University
record_format Article
series Guangxi Yike Daxue xuebao
spelling doaj-art-9a0b1ee8881a45b080f668d6370bc2e32025-08-20T01:50:22ZzhoEditorial Office of Journal of Guangxi Medical UniversityGuangxi Yike Daxue xuebao1005-930X2024-08-014181213121910.16190/j.cnki.45-1211/r.2024.08.016gxykdxxb-41-8-1213Research progress of clozapine-induced myocarditisLI Qianqian0FENG Qian1CHEN Jizong2ZHENG Xin3WANG Weiwei4The Second Affiliated Hospital of Kunming Medical University, Kunming 650000, ChinaThe Second Affiliated Hospital of Kunming Medical University, Kunming 650000, ChinaThe Second Affiliated Hospital of Kunming Medical University, Kunming 650000, ChinaThe Second Affiliated Hospital of Kunming Medical University, Kunming 650000, ChinaThe Second Affiliated Hospital of Kunming Medical University, Kunming 650000, ChinaClozapine (CLZ), as a unique and effective atypical antipsychotic drug, has achieved good results in the treatment of schizophrenia, but its cardiotoxicity has attracted the attention of clinicians. Clozapine-induced myocarditis (CIM) is a rare but serious cardiovascular adverse event during the use of clozapine, the pathogenesis of which is unknown. The picture is further complicated by considering that people with schizophrenia may have cognitive impairments that make early heart damage difficult to detect. Therefore, this review summarizes the clinical manifestations, auxiliary examination characteristics, risk factors and possible pathogenesis of CIM, providing clues for doctors to diagnose, monitor and treat the CIM.https://journal.gxmu.edu.cn/article/doi/10.16190/j.cnki.45-1211/r.2024.08.016clozapineclozapine-induced myocarditisdiagnosispathogenesisrisk factors
spellingShingle LI Qianqian
FENG Qian
CHEN Jizong
ZHENG Xin
WANG Weiwei
Research progress of clozapine-induced myocarditis
Guangxi Yike Daxue xuebao
clozapine
clozapine-induced myocarditis
diagnosis
pathogenesis
risk factors
title Research progress of clozapine-induced myocarditis
title_full Research progress of clozapine-induced myocarditis
title_fullStr Research progress of clozapine-induced myocarditis
title_full_unstemmed Research progress of clozapine-induced myocarditis
title_short Research progress of clozapine-induced myocarditis
title_sort research progress of clozapine induced myocarditis
topic clozapine
clozapine-induced myocarditis
diagnosis
pathogenesis
risk factors
url https://journal.gxmu.edu.cn/article/doi/10.16190/j.cnki.45-1211/r.2024.08.016
work_keys_str_mv AT liqianqian researchprogressofclozapineinducedmyocarditis
AT fengqian researchprogressofclozapineinducedmyocarditis
AT chenjizong researchprogressofclozapineinducedmyocarditis
AT zhengxin researchprogressofclozapineinducedmyocarditis
AT wangweiwei researchprogressofclozapineinducedmyocarditis