Estimation of Apelin Levels in Iraqi Patients with Type II Diabetic Peripheral Neuropathy
Diabetes mellitus type 2 (T2DM) is a chronic and progressive condition, which affects people all around the world. The risk of complications increases with age if the disease is not managed properly. Diabetic neuropathy is caused by excessive blood glucose and lipid levels, resulting in nerve damag...
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University of Baghdad, College of Science for Women
2023-10-01
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| Series: | مجلة بغداد للعلوم |
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| Online Access: | https://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/7566 |
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| author | Hadel Khalid Jaid Fayhaa Muqdad Khaleel Isam Noori Salman Baydaa Ahmed Abd |
| author_facet | Hadel Khalid Jaid Fayhaa Muqdad Khaleel Isam Noori Salman Baydaa Ahmed Abd |
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Diabetes mellitus type 2 (T2DM) is a chronic and progressive condition, which affects people all around the world. The risk of complications increases with age if the disease is not managed properly. Diabetic neuropathy is caused by excessive blood glucose and lipid levels, resulting in nerve damage. Apelin is a peptide hormone that is found in different human organs, including the central nervous system and adipose tissue. The aim of this study is to estimate Apelin levels in diabetes type 2 and Diabetic peripheral Neuropathy (DPN) Iraqi patients and show the extent of peripheral nerve damage. The current study included 120 participants: 40 patients with Diabetes Mellitus, 40 patients with Diabetic peripheral Neuropathy, and 40 healthy persons as control, the age range of 34-66 years, matched in age and sex. For all groups, fasting blood sugar, lipid profile (Cholesterol, Triglyceride, High-density lipoprotein, Low-density lipoprotein, and very-low-density lipoprotein), HbA1c, serum total Apelin levels, BMI, and Waist to Hip Ratio were calculated. The results showed highly increase in Apelin levels in neuropathy patients 670.4 ± 41.67 pg/ml compared to diabetes patients 247.6 ± 20.37 pg/ml nd healthy people 208.02 ± 8.30 pg/ml with a P value=0.001. Body Mass Index showed increase in diabetic and neuropathy patients compared with control group 31.05 ± 1.01 kg/m2, 31.05 ± 0.73 kg/m2, versus 23.92 ± 0.16 kg/m2, respectively, with a P value=0.001. The result showed a significant increase in lipid profile with p≤0.05, except HDL which showed a significant decrease p≤0.05. The present study concluded that incremented Apelin levels have an important role in Neuropathy pathogenesis and could determine the extent of peripheral nerve damage by the high levels in the blood due to their presence in the central nervous system. Also, increasing BMI, excessive lipid, and duration of disease showed a progressive role in DM and neuropathy and cause damage to the nerves, and play roles in the development of complications.
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| format | Article |
| id | doaj-art-9a06d9ec4159486bb7a6c9f7cabf62ab |
| institution | Kabale University |
| issn | 2078-8665 2411-7986 |
| language | English |
| publishDate | 2023-10-01 |
| publisher | University of Baghdad, College of Science for Women |
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| series | مجلة بغداد للعلوم |
| spelling | doaj-art-9a06d9ec4159486bb7a6c9f7cabf62ab2025-08-20T03:35:24ZengUniversity of Baghdad, College of Science for Womenمجلة بغداد للعلوم2078-86652411-79862023-10-0120510.21123/bsj.2023.7566Estimation of Apelin Levels in Iraqi Patients with Type II Diabetic Peripheral NeuropathyHadel Khalid Jaid0Fayhaa Muqdad Khaleel 1Isam Noori Salman2Baydaa Ahmed Abd 3Department of Chemistry, College of Science for Women, University of Baghdad, Baghdad, IraqDepartment of Chemistry, College of Science for Women, University of Baghdad, Baghdad, IraqThe National Diabetes Center, Mustansiriyah University, Baghdad, IraqNational Diabetes Center, Mustansiriyah University, Baghdad, Iraq Diabetes mellitus type 2 (T2DM) is a chronic and progressive condition, which affects people all around the world. The risk of complications increases with age if the disease is not managed properly. Diabetic neuropathy is caused by excessive blood glucose and lipid levels, resulting in nerve damage. Apelin is a peptide hormone that is found in different human organs, including the central nervous system and adipose tissue. The aim of this study is to estimate Apelin levels in diabetes type 2 and Diabetic peripheral Neuropathy (DPN) Iraqi patients and show the extent of peripheral nerve damage. The current study included 120 participants: 40 patients with Diabetes Mellitus, 40 patients with Diabetic peripheral Neuropathy, and 40 healthy persons as control, the age range of 34-66 years, matched in age and sex. For all groups, fasting blood sugar, lipid profile (Cholesterol, Triglyceride, High-density lipoprotein, Low-density lipoprotein, and very-low-density lipoprotein), HbA1c, serum total Apelin levels, BMI, and Waist to Hip Ratio were calculated. The results showed highly increase in Apelin levels in neuropathy patients 670.4 ± 41.67 pg/ml compared to diabetes patients 247.6 ± 20.37 pg/ml nd healthy people 208.02 ± 8.30 pg/ml with a P value=0.001. Body Mass Index showed increase in diabetic and neuropathy patients compared with control group 31.05 ± 1.01 kg/m2, 31.05 ± 0.73 kg/m2, versus 23.92 ± 0.16 kg/m2, respectively, with a P value=0.001. The result showed a significant increase in lipid profile with p≤0.05, except HDL which showed a significant decrease p≤0.05. The present study concluded that incremented Apelin levels have an important role in Neuropathy pathogenesis and could determine the extent of peripheral nerve damage by the high levels in the blood due to their presence in the central nervous system. Also, increasing BMI, excessive lipid, and duration of disease showed a progressive role in DM and neuropathy and cause damage to the nerves, and play roles in the development of complications. https://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/7566Apelin, Body Mass Index, Diabetic Peripheral neuropathy, Glycosylated hemoglobin, Lipid profile, Type 2 Diabetes mellitus |
| spellingShingle | Hadel Khalid Jaid Fayhaa Muqdad Khaleel Isam Noori Salman Baydaa Ahmed Abd Estimation of Apelin Levels in Iraqi Patients with Type II Diabetic Peripheral Neuropathy مجلة بغداد للعلوم Apelin, Body Mass Index, Diabetic Peripheral neuropathy, Glycosylated hemoglobin, Lipid profile, Type 2 Diabetes mellitus |
| title | Estimation of Apelin Levels in Iraqi Patients with Type II Diabetic Peripheral Neuropathy |
| title_full | Estimation of Apelin Levels in Iraqi Patients with Type II Diabetic Peripheral Neuropathy |
| title_fullStr | Estimation of Apelin Levels in Iraqi Patients with Type II Diabetic Peripheral Neuropathy |
| title_full_unstemmed | Estimation of Apelin Levels in Iraqi Patients with Type II Diabetic Peripheral Neuropathy |
| title_short | Estimation of Apelin Levels in Iraqi Patients with Type II Diabetic Peripheral Neuropathy |
| title_sort | estimation of apelin levels in iraqi patients with type ii diabetic peripheral neuropathy |
| topic | Apelin, Body Mass Index, Diabetic Peripheral neuropathy, Glycosylated hemoglobin, Lipid profile, Type 2 Diabetes mellitus |
| url | https://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/7566 |
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