The Role of Inflammasome Activation in Early HIV Infection
The inflammasome pathway is an important arm of the innate immune system that provides antiviral immunity against many viruses. The main pathways involved in virus infections include the NLRP3, IFI16, and AIM2 pathways. However, a succinct understanding of its role in HIV is not yet well elucidated....
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2021/1487287 |
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| _version_ | 1849404861332848640 |
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| author | Cyril Jabea Ekabe Njinju Asaba Clinton Jules Kehbila Ngangom Chouamo Franck |
| author_facet | Cyril Jabea Ekabe Njinju Asaba Clinton Jules Kehbila Ngangom Chouamo Franck |
| author_sort | Cyril Jabea Ekabe |
| collection | DOAJ |
| description | The inflammasome pathway is an important arm of the innate immune system that provides antiviral immunity against many viruses. The main pathways involved in virus infections include the NLRP3, IFI16, and AIM2 pathways. However, a succinct understanding of its role in HIV is not yet well elucidated. In this review, we showed that NLRP3 inflammasome activation plays a vital role in inhibiting HIV entry into target cells via the purinergic pathway; IFI16 detects intracellular HIV ssDNA, triggers interferon I and III production, and inhibits HIV transcription; and AIM2 binds to HIV dsDNA and triggers acute inflammation and pyroptosis. Remarkably, by understanding these mechanisms, new therapeutic strategies can be developed against the disease. |
| format | Article |
| id | doaj-art-9a02fbd439764f339ecebb7104f5cf44 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-9a02fbd439764f339ecebb7104f5cf442025-08-20T03:36:52ZengWileyJournal of Immunology Research2314-88612314-71562021-01-01202110.1155/2021/14872871487287The Role of Inflammasome Activation in Early HIV InfectionCyril Jabea Ekabe0Njinju Asaba Clinton1Jules Kehbila2Ngangom Chouamo Franck3Grace Community Health and Development Association, P. O. Box, 15 Kumba, Southwest Region, CameroonGrace Community Health and Development Association, P. O. Box, 15 Kumba, Southwest Region, CameroonGrace Community Health and Development Association, P. O. Box, 15 Kumba, Southwest Region, CameroonFaculty of Health Sciences, University of Buea, CameroonThe inflammasome pathway is an important arm of the innate immune system that provides antiviral immunity against many viruses. The main pathways involved in virus infections include the NLRP3, IFI16, and AIM2 pathways. However, a succinct understanding of its role in HIV is not yet well elucidated. In this review, we showed that NLRP3 inflammasome activation plays a vital role in inhibiting HIV entry into target cells via the purinergic pathway; IFI16 detects intracellular HIV ssDNA, triggers interferon I and III production, and inhibits HIV transcription; and AIM2 binds to HIV dsDNA and triggers acute inflammation and pyroptosis. Remarkably, by understanding these mechanisms, new therapeutic strategies can be developed against the disease.http://dx.doi.org/10.1155/2021/1487287 |
| spellingShingle | Cyril Jabea Ekabe Njinju Asaba Clinton Jules Kehbila Ngangom Chouamo Franck The Role of Inflammasome Activation in Early HIV Infection Journal of Immunology Research |
| title | The Role of Inflammasome Activation in Early HIV Infection |
| title_full | The Role of Inflammasome Activation in Early HIV Infection |
| title_fullStr | The Role of Inflammasome Activation in Early HIV Infection |
| title_full_unstemmed | The Role of Inflammasome Activation in Early HIV Infection |
| title_short | The Role of Inflammasome Activation in Early HIV Infection |
| title_sort | role of inflammasome activation in early hiv infection |
| url | http://dx.doi.org/10.1155/2021/1487287 |
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