Loss function of tumor suppressor FRMD8 confers resistance to tamoxifen therapy via a dual mechanism

Loss function of tumor suppressor FRMD8 confers resistance to tamoxifen therapy via a dual mechanism

Approximately 40% ERα-positive breast cancer patients suffer from therapeutic resistance to tamoxifen. Although reduced ERα level is the major cause of tamoxifen resistance, the underlying mechanisms remain elusive. Here, we report that FRMD8 raises the level of ERα at both transcriptional and post-...

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Bibliographic Details
Main Authors: Weijie Wu, Miao Yu, Qianchen Li, Yiqian Zhao, Lei Zhang, Yi Sun, Zhenbin Wang, Yuqing Gong, Wenjing Wang, Chenying Liu, Jing Zhang, Yan Tang, Xiaojie Xu, Xiaojing Guo, Jun Zhan, Hongquan Zhang
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2025-04-01
Series:eLife
Subjects:
FRMD8
breast cancer
ERα
tamoxifen resistance
UBE3A
Online Access:https://elifesciences.org/articles/101888
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https://elifesciences.org/articles/101888

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