Liver Resection Promotes (Regulates) Proinflammatory Cytokines in Patients with Hepatocellular Carcinoma
Background. Several animal studies have shown the roles of cytokines in regulating liver regeneration following liver resection (LR), which is a type of surgery designed to remove cancerous tumors from the liver. This study investigated how the expressions and serum levels of some pro- and anti-infl...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Canadian Journal of Gastroenterology and Hepatology |
| Online Access: | http://dx.doi.org/10.1155/2021/5593655 |
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| author | Farshid Fathi Behnam Sanei Mazdak Ganjalikhani Hakemi Reza F. Saidi Abbas Rezaei |
| author_facet | Farshid Fathi Behnam Sanei Mazdak Ganjalikhani Hakemi Reza F. Saidi Abbas Rezaei |
| author_sort | Farshid Fathi |
| collection | DOAJ |
| description | Background. Several animal studies have shown the roles of cytokines in regulating liver regeneration following liver resection (LR), which is a type of surgery designed to remove cancerous tumors from the liver. This study investigated how the expressions and serum levels of some pro- and anti-inflammatory cytokines in patients with hepatocellular carcinoma (HCC) were changed during LR. Methods. Liver tissues from 15 patients with HCC were collected and the levels of interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), IL-1α, IL-1 β, IL-10, and transforming growth factor-beta1 (TGF-β1) were assessed using real-time PCR assay at different times before and after LR. The serum values of TNF-α and IL-6 were also measured by ELISA. Results. After 60 and 90 minutes of LR, IL-6 gene expression was significantly increased P<0.001−0.05. The same trend was also observed in TNF-α expression after 90 minutes of LR P<0.01. No significant changes were observed in the expressions of IL-1α, IL-1β, IL-10, and TGF-β1 before and after LR. In addition, LR had significant effects on TNF-α and IL-6 serum levels P<0.05−0.0001. Conclusion. Our data provided further evidence to reveal that IL-6 and TNF-α cytokines are critical to improve liver regeneration. |
| format | Article |
| id | doaj-art-9a00509e65c44c3f894ed37713da81f8 |
| institution | Kabale University |
| issn | 2291-2789 2291-2797 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology and Hepatology |
| spelling | doaj-art-9a00509e65c44c3f894ed37713da81f82025-02-03T00:58:47ZengWileyCanadian Journal of Gastroenterology and Hepatology2291-27892291-27972021-01-01202110.1155/2021/55936555593655Liver Resection Promotes (Regulates) Proinflammatory Cytokines in Patients with Hepatocellular CarcinomaFarshid Fathi0Behnam Sanei1Mazdak Ganjalikhani Hakemi2Reza F. Saidi3Abbas Rezaei4Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranDepartment of Hepatobiliary & Pancreatic Surgery and Liver Transplantation, Al-Zahra Hospital, Isfahan University of Medical Sciences, Isfahan, IranDepartment of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranDivision of Transplant Services, Department of Surgery, SUNY Upstate Medical University Syracuse, Syracuse, NY 13210, USADepartment of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranBackground. Several animal studies have shown the roles of cytokines in regulating liver regeneration following liver resection (LR), which is a type of surgery designed to remove cancerous tumors from the liver. This study investigated how the expressions and serum levels of some pro- and anti-inflammatory cytokines in patients with hepatocellular carcinoma (HCC) were changed during LR. Methods. Liver tissues from 15 patients with HCC were collected and the levels of interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), IL-1α, IL-1 β, IL-10, and transforming growth factor-beta1 (TGF-β1) were assessed using real-time PCR assay at different times before and after LR. The serum values of TNF-α and IL-6 were also measured by ELISA. Results. After 60 and 90 minutes of LR, IL-6 gene expression was significantly increased P<0.001−0.05. The same trend was also observed in TNF-α expression after 90 minutes of LR P<0.01. No significant changes were observed in the expressions of IL-1α, IL-1β, IL-10, and TGF-β1 before and after LR. In addition, LR had significant effects on TNF-α and IL-6 serum levels P<0.05−0.0001. Conclusion. Our data provided further evidence to reveal that IL-6 and TNF-α cytokines are critical to improve liver regeneration.http://dx.doi.org/10.1155/2021/5593655 |
| spellingShingle | Farshid Fathi Behnam Sanei Mazdak Ganjalikhani Hakemi Reza F. Saidi Abbas Rezaei Liver Resection Promotes (Regulates) Proinflammatory Cytokines in Patients with Hepatocellular Carcinoma Canadian Journal of Gastroenterology and Hepatology |
| title | Liver Resection Promotes (Regulates) Proinflammatory Cytokines in Patients with Hepatocellular Carcinoma |
| title_full | Liver Resection Promotes (Regulates) Proinflammatory Cytokines in Patients with Hepatocellular Carcinoma |
| title_fullStr | Liver Resection Promotes (Regulates) Proinflammatory Cytokines in Patients with Hepatocellular Carcinoma |
| title_full_unstemmed | Liver Resection Promotes (Regulates) Proinflammatory Cytokines in Patients with Hepatocellular Carcinoma |
| title_short | Liver Resection Promotes (Regulates) Proinflammatory Cytokines in Patients with Hepatocellular Carcinoma |
| title_sort | liver resection promotes regulates proinflammatory cytokines in patients with hepatocellular carcinoma |
| url | http://dx.doi.org/10.1155/2021/5593655 |
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