Autoimmune Encephalitis. An Analysis of Three Cases
The diagnosis of diseases from the group of autoimmune encephalitis (AE) requires a detailed analysis of clinical data and correlation of results from a wide range of laboratory and instrumental research methods. This article presents three clinical cases of patients with AE. In one patient, AE was...
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| Format: | Article |
| Language: | Russian |
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Sklifosovsky Research Institute for Emergency Medicine, Public Healthcare Institution of Moscow Healthcare Department
2024-01-01
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| Series: | Неотложная медицинская помощь |
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| Online Access: | https://www.jnmp.ru/jour/article/view/1733 |
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| author | G. R. Ramazanov E. V. Shevchenko E. M. Bardina Kh. V. Korigova E. A. Kovaleva L. Kh.-B. Akhmatkhanova I. S. Aliev M. V Sinkin |
| author_facet | G. R. Ramazanov E. V. Shevchenko E. M. Bardina Kh. V. Korigova E. A. Kovaleva L. Kh.-B. Akhmatkhanova I. S. Aliev M. V Sinkin |
| author_sort | G. R. Ramazanov |
| collection | DOAJ |
| description | The diagnosis of diseases from the group of autoimmune encephalitis (AE) requires a detailed analysis of clinical data and correlation of results from a wide range of laboratory and instrumental research methods. This article presents three clinical cases of patients with AE. In one patient, AE was associated with a malignant neoplasm, in the second one – with the novel coronavirus infection, and in the third patient, no comorbid pathology was detected. The specific type of encephalitis was determined for each of the three patients. The diagnosis of “autoimmune limbic encephalitis” was established in two patients based on visualization of changes in the medial temporal structures in the magnetic resonance imaging of the brain, detection of pathological bioelectrical activity in the temporal lobe cortex in electroencephalography, and pleocytosis in cerebrospinal fluid. The diagnosis of “anti-NMDA receptor encephalitis” was made based on the detection of specific antibodies to the subunit of the corresponding receptor. Neurological deficit regression was observed in two patients after the application of combined immune therapy methods and in one patient without the use of immune therapy. |
| format | Article |
| id | doaj-art-99ff5b0fa2264b7abccee908ec04643e |
| institution | Kabale University |
| issn | 2223-9022 2541-8017 |
| language | Russian |
| publishDate | 2024-01-01 |
| publisher | Sklifosovsky Research Institute for Emergency Medicine, Public Healthcare Institution of Moscow Healthcare Department |
| record_format | Article |
| series | Неотложная медицинская помощь |
| spelling | doaj-art-99ff5b0fa2264b7abccee908ec04643e2025-08-20T03:35:34ZrusSklifosovsky Research Institute for Emergency Medicine, Public Healthcare Institution of Moscow Healthcare DepartmentНеотложная медицинская помощь2223-90222541-80172024-01-0112468368910.23934/2223-9022-2023-12-4-683-689907Autoimmune Encephalitis. An Analysis of Three CasesG. R. Ramazanov0E. V. Shevchenko1E. M. Bardina2Kh. V. Korigova3E. A. Kovaleva4L. Kh.-B. Akhmatkhanova5I. S. Aliev6M. V Sinkin7N.V. Sklifosovsky Research Institute for Emergency MedicineN.V. Sklifosovsky Research Institute for Emergency MedicineN.V. Sklifosovsky Research Institute for Emergency MedicineN.V. Sklifosovsky Research Institute for Emergency MedicineN.V. Sklifosovsky Research Institute for Emergency MedicineN.V. Sklifosovsky Research Institute for Emergency MedicineN.V. Sklifosovsky Research Institute for Emergency MedicineN.V. Sklifosovsky Research Institute for Emergency MedicineThe diagnosis of diseases from the group of autoimmune encephalitis (AE) requires a detailed analysis of clinical data and correlation of results from a wide range of laboratory and instrumental research methods. This article presents three clinical cases of patients with AE. In one patient, AE was associated with a malignant neoplasm, in the second one – with the novel coronavirus infection, and in the third patient, no comorbid pathology was detected. The specific type of encephalitis was determined for each of the three patients. The diagnosis of “autoimmune limbic encephalitis” was established in two patients based on visualization of changes in the medial temporal structures in the magnetic resonance imaging of the brain, detection of pathological bioelectrical activity in the temporal lobe cortex in electroencephalography, and pleocytosis in cerebrospinal fluid. The diagnosis of “anti-NMDA receptor encephalitis” was made based on the detection of specific antibodies to the subunit of the corresponding receptor. Neurological deficit regression was observed in two patients after the application of combined immune therapy methods and in one patient without the use of immune therapy.https://www.jnmp.ru/jour/article/view/1733autoimmuneanti-nmda receptorlimbic encephalitisautoantibodiesmagnetic resonance imagingelectroencephalography |
| spellingShingle | G. R. Ramazanov E. V. Shevchenko E. M. Bardina Kh. V. Korigova E. A. Kovaleva L. Kh.-B. Akhmatkhanova I. S. Aliev M. V Sinkin Autoimmune Encephalitis. An Analysis of Three Cases Неотложная медицинская помощь autoimmune anti-nmda receptor limbic encephalitis autoantibodies magnetic resonance imaging electroencephalography |
| title | Autoimmune Encephalitis. An Analysis of Three Cases |
| title_full | Autoimmune Encephalitis. An Analysis of Three Cases |
| title_fullStr | Autoimmune Encephalitis. An Analysis of Three Cases |
| title_full_unstemmed | Autoimmune Encephalitis. An Analysis of Three Cases |
| title_short | Autoimmune Encephalitis. An Analysis of Three Cases |
| title_sort | autoimmune encephalitis an analysis of three cases |
| topic | autoimmune anti-nmda receptor limbic encephalitis autoantibodies magnetic resonance imaging electroencephalography |
| url | https://www.jnmp.ru/jour/article/view/1733 |
| work_keys_str_mv | AT grramazanov autoimmuneencephalitisananalysisofthreecases AT evshevchenko autoimmuneencephalitisananalysisofthreecases AT embardina autoimmuneencephalitisananalysisofthreecases AT khvkorigova autoimmuneencephalitisananalysisofthreecases AT eakovaleva autoimmuneencephalitisananalysisofthreecases AT lkhbakhmatkhanova autoimmuneencephalitisananalysisofthreecases AT isaliev autoimmuneencephalitisananalysisofthreecases AT mvsinkin autoimmuneencephalitisananalysisofthreecases |