Fragments of the bacterial toxin microcin B17 as gyrase poisons.

Fragments of the bacterial toxin microcin B17 as gyrase poisons.

Fluoroquinolones are very important drugs in the clinical antibacterial arsenal; their success is principally due to their mode of action: the stabilisation of a gyrase-DNA intermediate (the cleavage complex), which triggers a chain of events leading to cell death. Microcin B17 (MccB17) is a modifie...

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Bibliographic Details
Main Authors: Frédéric Collin, Robert E Thompson, Katrina A Jolliffe, Richard J Payne, Anthony Maxwell
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0061459&type=printable
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