Clostridium butyricum enhances cognitive function in APP/PS1 mice by modulating neuropathology and regulating acetic acid levels in the gut microbiota
ABSTRACT The amyloid deposition-to-cognitive impairment pathway is crucial in Alzheimer’s disease (AD) pathogenesis, with gut microbes influencing its development. Our study evaluated Clostridium butyricum MIYAIRI 588 (CBM588) as a potential AD treatment. In APP/PS1 mice, CBM588 improved cognitive f...
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| Main Authors: | Ye Shiqing, Lu Xinjie, Zhu Xiaotong, Chen Jiayan, Lu Jiahai, Chen Xiaodong, Lou Yongliang, Li Xiang |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
American Society for Microbiology
2025-08-01
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| Series: | Microbiology Spectrum |
| Subjects: | |
| Online Access: | https://journals.asm.org/doi/10.1128/spectrum.00178-25 |
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