Modulation of intracellular kinase signaling to improve TIL stemness and function for adoptive cell therapy

Modulation of intracellular kinase signaling to improve TIL stemness and function for adoptive cell therapy

Abstract Introduction Adoptive cellular therapy with tumor‐infiltrating lymphocytes (TIL) has demonstrated promising clinical benefits in several solid tumors, but the efficacy of this therapy might be compromised by the “prone‐to‐exhaustion” phenotype of TIL and poor persistence in vivo. This calls...

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Main Authors: Hao Feng, Ling Qiu, Zixiao Shi, Yao Sheng, Peipei Zhao, Di Zhou, Fei Li, Hailin Yu, Yanan You, Hui Wang, Ming Li, Shurong Zhu, Yan Du, Jun Cui, Jingwei Sun, Yarong Liu, Hua Jiang, Xin Wu
Format: Article
Language:English
Published: Wiley 2023-02-01
Series:Cancer Medicine
Subjects:
AKT inhibitor
AKT KO
PI3K inhibitor
TIL manufacture
tumor‐infiltrating lymphocyte therapy
Online Access:https://doi.org/10.1002/cam4.5095
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