KDM4B enhances immune surveillance via demethylating cGAS

KDM4B enhances immune surveillance via demethylating cGAS

Abstract Cyclic GMP–AMP synthase (cGAS) serves as a crucial sentinel in innate immunity by sensing cytosolic DNA, yet the molecular mechanisms governing its activation remain incompletely understood. Here, we identify lysine demethylase 4B (KDM4B) as the specific demethylase that erases cGAS K350 me...

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Main Authors: Qiao Peng, Huimin Zhuo, Minkang Wu, Yun Hao, Yiyi Zhang, Yuying Zheng, Lei Yu, Lin Han, Hui Ren, Yingcong Wang, Zhijie Gao, Leilei Wu, Qi Lin, Chunhua Lu, Jinghua Li, Ping Wang, Lan Fang, Haihong Yu, Meiling Lu
Format: Article
Language:English
Published: Nature Publishing Group 2025-07-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-025-07792-w
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