Sound innovations for biofabrication and tissue engineering
Abstract Advanced biofabrication techniques can create tissue-like constructs that can be applied for reconstructive surgery or as in vitro three-dimensional (3D) models for disease modeling and drug screening. While various biofabrication techniques have recently been widely reviewed in the literat...
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2024-11-01
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| Series: | Microsystems & Nanoengineering |
| Online Access: | https://doi.org/10.1038/s41378-024-00759-5 |
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| _version_ | 1850162860870598656 |
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| author | Mengxi Wu Zhiteng Ma Zhenhua Tian Joseph T. Rich Xin He Jianping Xia Ye He Kaichun Yang Shujie Yang Kam W. Leong Luke P. Lee Tony Jun Huang |
| author_facet | Mengxi Wu Zhiteng Ma Zhenhua Tian Joseph T. Rich Xin He Jianping Xia Ye He Kaichun Yang Shujie Yang Kam W. Leong Luke P. Lee Tony Jun Huang |
| author_sort | Mengxi Wu |
| collection | DOAJ |
| description | Abstract Advanced biofabrication techniques can create tissue-like constructs that can be applied for reconstructive surgery or as in vitro three-dimensional (3D) models for disease modeling and drug screening. While various biofabrication techniques have recently been widely reviewed in the literature, acoustics-based technologies still need to be explored. The rapidly increasing number of publications in the past two decades exploring the application of acoustic technologies highlights the tremendous potential of these technologies. In this review, we contend that acoustics-based methods can address many limitations inherent in other biofabrication techniques due to their unique advantages: noncontact manipulation, biocompatibility, deep tissue penetrability, versatility, precision in-scaffold control, high-throughput capabilities, and the ability to assemble multilayered structures. We discuss the mechanisms by which acoustics directly dictate cell assembly across various biostructures and examine how the advent of novel acoustic technologies, along with their integration with traditional methods, offers innovative solutions for enhancing the functionality of organoids. Acoustic technologies are poised to address fundamental challenges in biofabrication and tissue engineering and show promise for advancing the field in the coming years. |
| format | Article |
| id | doaj-art-99ecbb12ab86479bb3e05411cf845060 |
| institution | OA Journals |
| issn | 2055-7434 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Microsystems & Nanoengineering |
| spelling | doaj-art-99ecbb12ab86479bb3e05411cf8450602025-08-20T02:22:26ZengNature Publishing GroupMicrosystems & Nanoengineering2055-74342024-11-0110111910.1038/s41378-024-00759-5Sound innovations for biofabrication and tissue engineeringMengxi Wu0Zhiteng Ma1Zhenhua Tian2Joseph T. Rich3Xin He4Jianping Xia5Ye He6Kaichun Yang7Shujie Yang8Kam W. Leong9Luke P. Lee10Tony Jun Huang11School of Mechanical Engineering, Dalian University of TechnologyThomas Lord Department of Mechanical Engineering and Materials Science, Duke UniversityDepartment of Mechanical Engineering, Virginia Polytechnic Institute and State UniversityDepartment of Biomedical Engineering, Duke UniversitySchool of Mechanical Engineering, Dalian University of TechnologyThomas Lord Department of Mechanical Engineering and Materials Science, Duke UniversityThomas Lord Department of Mechanical Engineering and Materials Science, Duke UniversityThomas Lord Department of Mechanical Engineering and Materials Science, Duke UniversityThomas Lord Department of Mechanical Engineering and Materials Science, Duke UniversityDepartment of Biomedical Engineering, Columbia UniversityRenal Division and Division of Engineering in Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical SchoolThomas Lord Department of Mechanical Engineering and Materials Science, Duke UniversityAbstract Advanced biofabrication techniques can create tissue-like constructs that can be applied for reconstructive surgery or as in vitro three-dimensional (3D) models for disease modeling and drug screening. While various biofabrication techniques have recently been widely reviewed in the literature, acoustics-based technologies still need to be explored. The rapidly increasing number of publications in the past two decades exploring the application of acoustic technologies highlights the tremendous potential of these technologies. In this review, we contend that acoustics-based methods can address many limitations inherent in other biofabrication techniques due to their unique advantages: noncontact manipulation, biocompatibility, deep tissue penetrability, versatility, precision in-scaffold control, high-throughput capabilities, and the ability to assemble multilayered structures. We discuss the mechanisms by which acoustics directly dictate cell assembly across various biostructures and examine how the advent of novel acoustic technologies, along with their integration with traditional methods, offers innovative solutions for enhancing the functionality of organoids. Acoustic technologies are poised to address fundamental challenges in biofabrication and tissue engineering and show promise for advancing the field in the coming years.https://doi.org/10.1038/s41378-024-00759-5 |
| spellingShingle | Mengxi Wu Zhiteng Ma Zhenhua Tian Joseph T. Rich Xin He Jianping Xia Ye He Kaichun Yang Shujie Yang Kam W. Leong Luke P. Lee Tony Jun Huang Sound innovations for biofabrication and tissue engineering Microsystems & Nanoengineering |
| title | Sound innovations for biofabrication and tissue engineering |
| title_full | Sound innovations for biofabrication and tissue engineering |
| title_fullStr | Sound innovations for biofabrication and tissue engineering |
| title_full_unstemmed | Sound innovations for biofabrication and tissue engineering |
| title_short | Sound innovations for biofabrication and tissue engineering |
| title_sort | sound innovations for biofabrication and tissue engineering |
| url | https://doi.org/10.1038/s41378-024-00759-5 |
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