The nexus of long noncoding RNAs, splicing factors, alternative splicing and their modulations
The process of alternative splicing (AS) is widely deregulated in a variety of cancers. Splicing is dependent upon splicing factors. Recently, several long noncoding RNAs (lncRNAs) have been shown to regulate AS by directly/indirectly interacting with splicing factors. This review focuses on the reg...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | RNA Biology |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/15476286.2023.2286099 |
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| author | Pushkar Malakar Sudhanshu Shukla Meghna Mondal Rajesh Kumar Kar Jawed Akhtar Siddiqui |
| author_facet | Pushkar Malakar Sudhanshu Shukla Meghna Mondal Rajesh Kumar Kar Jawed Akhtar Siddiqui |
| author_sort | Pushkar Malakar |
| collection | DOAJ |
| description | The process of alternative splicing (AS) is widely deregulated in a variety of cancers. Splicing is dependent upon splicing factors. Recently, several long noncoding RNAs (lncRNAs) have been shown to regulate AS by directly/indirectly interacting with splicing factors. This review focuses on the regulation of AS by lncRNAs through their interaction with splicing factors. AS mis-regulation caused by either mutation in splicing factors or deregulated expression of splicing factors and lncRNAs has been shown to be involved in cancer development and progression, making aberrant splicing, splicing factors and lncRNA suitable targets for cancer therapy. This review also addresses some of the current approaches used to target AS, splicing factors and lncRNAs. Finally, we discuss research challenges, some of the unanswered questions in the field and provide recommendations to advance understanding of the nexus of lncRNAs, AS and splicing factors in cancer. |
| format | Article |
| id | doaj-art-99eaa88f6c7c440d811ac0ce568b545c |
| institution | OA Journals |
| issn | 1547-6286 1555-8584 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | RNA Biology |
| spelling | doaj-art-99eaa88f6c7c440d811ac0ce568b545c2025-08-20T01:59:16ZengTaylor & Francis GroupRNA Biology1547-62861555-85842024-12-01211163510.1080/15476286.2023.2286099The nexus of long noncoding RNAs, splicing factors, alternative splicing and their modulationsPushkar Malakar0Sudhanshu Shukla1Meghna Mondal2Rajesh Kumar Kar3Jawed Akhtar Siddiqui4Department of Biomedical Science and Technology, School of Biological Sciences, Ramakrishna Mission Vivekananda Educational Research Institute (RKMVERI), Kolkata, IndiaDepartment of Biosciences and Bioengineering, Indian Institute of Technology Dharwad, Dharwad, Karnataka, IndiaDepartment of Biomedical Science and Technology, School of Biological Sciences, Ramakrishna Mission Vivekananda Educational Research Institute (RKMVERI), Kolkata, IndiaDepartment of Neurosurgery, School of Medicine, Yale University, New Haven, CT, USADepartment of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, USAThe process of alternative splicing (AS) is widely deregulated in a variety of cancers. Splicing is dependent upon splicing factors. Recently, several long noncoding RNAs (lncRNAs) have been shown to regulate AS by directly/indirectly interacting with splicing factors. This review focuses on the regulation of AS by lncRNAs through their interaction with splicing factors. AS mis-regulation caused by either mutation in splicing factors or deregulated expression of splicing factors and lncRNAs has been shown to be involved in cancer development and progression, making aberrant splicing, splicing factors and lncRNA suitable targets for cancer therapy. This review also addresses some of the current approaches used to target AS, splicing factors and lncRNAs. Finally, we discuss research challenges, some of the unanswered questions in the field and provide recommendations to advance understanding of the nexus of lncRNAs, AS and splicing factors in cancer.https://www.tandfonline.com/doi/10.1080/15476286.2023.2286099Alternative splicingsplicing factorslong noncoding RNAcancerantisense oligonucleotides |
| spellingShingle | Pushkar Malakar Sudhanshu Shukla Meghna Mondal Rajesh Kumar Kar Jawed Akhtar Siddiqui The nexus of long noncoding RNAs, splicing factors, alternative splicing and their modulations RNA Biology Alternative splicing splicing factors long noncoding RNA cancer antisense oligonucleotides |
| title | The nexus of long noncoding RNAs, splicing factors, alternative splicing and their modulations |
| title_full | The nexus of long noncoding RNAs, splicing factors, alternative splicing and their modulations |
| title_fullStr | The nexus of long noncoding RNAs, splicing factors, alternative splicing and their modulations |
| title_full_unstemmed | The nexus of long noncoding RNAs, splicing factors, alternative splicing and their modulations |
| title_short | The nexus of long noncoding RNAs, splicing factors, alternative splicing and their modulations |
| title_sort | nexus of long noncoding rnas splicing factors alternative splicing and their modulations |
| topic | Alternative splicing splicing factors long noncoding RNA cancer antisense oligonucleotides |
| url | https://www.tandfonline.com/doi/10.1080/15476286.2023.2286099 |
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