Critical COVID-19, Victivallaceae abundance, and celiac disease: A mediation Mendelian randomization study.
Celiac disease exhibits a higher prevalence among patients with coronavirus disease 2019. However, the potential influence of COVID-19 on celiac disease remains uncertain. Considering the significant association between gut microbiota alterations, COVID-19 and celiac disease, the two-step Mendelian...
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Public Library of Science (PLoS)
2024-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0301998&type=printable |
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| author | Yuxin Zou Manyi Pan Tianyu Zhou Lifeng Yan Yuntian Chen Junjie Yun Zhihua Wang Huaqi Guo Kai Zhang Weining Xiong |
| author_facet | Yuxin Zou Manyi Pan Tianyu Zhou Lifeng Yan Yuntian Chen Junjie Yun Zhihua Wang Huaqi Guo Kai Zhang Weining Xiong |
| author_sort | Yuxin Zou |
| collection | DOAJ |
| description | Celiac disease exhibits a higher prevalence among patients with coronavirus disease 2019. However, the potential influence of COVID-19 on celiac disease remains uncertain. Considering the significant association between gut microbiota alterations, COVID-19 and celiac disease, the two-step Mendelian randomization method was employed to investigate the genetic causality between COVID-19 and celiac disease, with gut microbiota as the potential mediators. We employed the genome-wide association study to select genetic instrumental variables associated with the exposure. Subsequently, these variables were utilized to evaluate the impact of COVID-19 on the risk of celiac disease and its potential influence on gut microbiota. Employing a two-step Mendelian randomization approach enabled the examination of potential causal relationships, encompassing: 1) the effects of COVID-19 infection, hospitalized COVID-19 and critical COVID-19 on the risk of celiac disease; 2) the influence of gut microbiota on celiac disease; and 3) the mediating impact of the gut microbiota between COVID-19 and the risk of celiac disease. Our findings revealed a significant association between critical COVID-19 and an elevated risk of celiac disease (inverse variance weighted [IVW]: P = 0.035). Furthermore, we observed an inverse correlation between critical COVID-19 and the abundance of Victivallaceae (IVW: P = 0.045). Notably, an increased Victivallaceae abundance exhibits a protective effect against the risk of celiac disease (IVW: P = 0.016). In conclusion, our analysis provides genetic evidence supporting the causal connection between critical COVID-19 and lower Victivallaceae abundance, thereby increasing the risk of celiac disease. |
| format | Article |
| id | doaj-art-99e1a8dd967c49348efac48332b0bb39 |
| institution | OA Journals |
| issn | 1932-6203 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-99e1a8dd967c49348efac48332b0bb392025-08-20T02:36:46ZengPublic Library of Science (PLoS)PLoS ONE1932-62032024-01-01195e030199810.1371/journal.pone.0301998Critical COVID-19, Victivallaceae abundance, and celiac disease: A mediation Mendelian randomization study.Yuxin ZouManyi PanTianyu ZhouLifeng YanYuntian ChenJunjie YunZhihua WangHuaqi GuoKai ZhangWeining XiongCeliac disease exhibits a higher prevalence among patients with coronavirus disease 2019. However, the potential influence of COVID-19 on celiac disease remains uncertain. Considering the significant association between gut microbiota alterations, COVID-19 and celiac disease, the two-step Mendelian randomization method was employed to investigate the genetic causality between COVID-19 and celiac disease, with gut microbiota as the potential mediators. We employed the genome-wide association study to select genetic instrumental variables associated with the exposure. Subsequently, these variables were utilized to evaluate the impact of COVID-19 on the risk of celiac disease and its potential influence on gut microbiota. Employing a two-step Mendelian randomization approach enabled the examination of potential causal relationships, encompassing: 1) the effects of COVID-19 infection, hospitalized COVID-19 and critical COVID-19 on the risk of celiac disease; 2) the influence of gut microbiota on celiac disease; and 3) the mediating impact of the gut microbiota between COVID-19 and the risk of celiac disease. Our findings revealed a significant association between critical COVID-19 and an elevated risk of celiac disease (inverse variance weighted [IVW]: P = 0.035). Furthermore, we observed an inverse correlation between critical COVID-19 and the abundance of Victivallaceae (IVW: P = 0.045). Notably, an increased Victivallaceae abundance exhibits a protective effect against the risk of celiac disease (IVW: P = 0.016). In conclusion, our analysis provides genetic evidence supporting the causal connection between critical COVID-19 and lower Victivallaceae abundance, thereby increasing the risk of celiac disease.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0301998&type=printable |
| spellingShingle | Yuxin Zou Manyi Pan Tianyu Zhou Lifeng Yan Yuntian Chen Junjie Yun Zhihua Wang Huaqi Guo Kai Zhang Weining Xiong Critical COVID-19, Victivallaceae abundance, and celiac disease: A mediation Mendelian randomization study. PLoS ONE |
| title | Critical COVID-19, Victivallaceae abundance, and celiac disease: A mediation Mendelian randomization study. |
| title_full | Critical COVID-19, Victivallaceae abundance, and celiac disease: A mediation Mendelian randomization study. |
| title_fullStr | Critical COVID-19, Victivallaceae abundance, and celiac disease: A mediation Mendelian randomization study. |
| title_full_unstemmed | Critical COVID-19, Victivallaceae abundance, and celiac disease: A mediation Mendelian randomization study. |
| title_short | Critical COVID-19, Victivallaceae abundance, and celiac disease: A mediation Mendelian randomization study. |
| title_sort | critical covid 19 victivallaceae abundance and celiac disease a mediation mendelian randomization study |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0301998&type=printable |
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