Apolipoprotein-b gen and its role in formation of essential hypertension
For two groups of Russian teenagers the proportion of deletion (Del) allele of the apolipoprotein-B gene polymorphism (ApoB, Ins/Del, rs17240441) was studied. One group of 70 teenagers with essential hypertension, and the comparison group - 73 healthy teenagers. In both groups, the most common genot...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
Scientific Сentre for Family Health and Human Reproduction Problems
2015-11-01
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| Series: | Acta Biomedica Scientifica |
| Subjects: | |
| Online Access: | https://www.actabiomedica.ru/jour/article/view/140 |
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| Summary: | For two groups of Russian teenagers the proportion of deletion (Del) allele of the apolipoprotein-B gene polymorphism (ApoB, Ins/Del, rs17240441) was studied. One group of 70 teenagers with essential hypertension, and the comparison group - 73 healthy teenagers. In both groups, the most common genotype was heterozygous genotype Ins/Del, in the group with essential hypertension it was 67,1 %, in the control group - 52,1 %. The frequency of Del allele in the group with essential hypertension was 47,9 %, which was significantly higher than in the comparison group - 30,1 % (p = 0,003). Thus, the high frequency of deletion allele in the studied group with hypertension indicates an increased risk of cardiovascular disease in this group in the future and has prognostic significance. |
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| ISSN: | 2541-9420 2587-9596 |