Advances in drug delivery systems utilizing blood cells and their membrane-derived microvesicles
The advancement of drug delivery systems (DDSs) in recent decades has demonstrated significant potential in enhancing the efficacy of pharmacological agents. Despite the approval of certain DDSs for clinical use, challenges such as rapid clearance from circulation, toxic accumulation in the body, an...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Drug Delivery |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/10717544.2024.2425156 |
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| author | Andong He Yuye Huang Chao Cao Xuejin Li |
| author_facet | Andong He Yuye Huang Chao Cao Xuejin Li |
| author_sort | Andong He |
| collection | DOAJ |
| description | The advancement of drug delivery systems (DDSs) in recent decades has demonstrated significant potential in enhancing the efficacy of pharmacological agents. Despite the approval of certain DDSs for clinical use, challenges such as rapid clearance from circulation, toxic accumulation in the body, and ineffective targeted delivery persist as obstacles to successful clinical application. Blood cell-based DDSs have emerged as a popular strategy for drug administration, offering enhanced biocompatibility, stability, and prolonged circulation. These DDSs are well-suited for systemic drug delivery and have played a crucial role in formulating optimal drug combinations for treating a variety of diseases in both preclinical studies and clinical trials. This review focuses on recent advancements and applications of DDSs utilizing blood cells and their membrane-derived microvesicles. It addresses the current therapeutic applications of blood cell-based DDSs at the organ and tissue levels, highlighting their successful deployment at the cellular level. Furthermore, it explores the mechanisms of cellular uptake of drug delivery vectors at the subcellular level. Additionally, the review discusses the opportunities and challenges associated with these DDSs. |
| format | Article |
| id | doaj-art-99d0f854c13e4fb0b0cda7e0235bc8bd |
| institution | DOAJ |
| issn | 1071-7544 1521-0464 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Drug Delivery |
| spelling | doaj-art-99d0f854c13e4fb0b0cda7e0235bc8bd2025-08-20T03:05:26ZengTaylor & Francis GroupDrug Delivery1071-75441521-04642024-12-0131110.1080/10717544.2024.2425156Advances in drug delivery systems utilizing blood cells and their membrane-derived microvesiclesAndong He0Yuye Huang1Chao Cao2Xuejin Li3Center for Medical and Engineering Innovation, Central Laboratory, The First Affiliated Hospital, Ningbo University School of Medicine, Ningbo, ChinaCenter for Medical and Engineering Innovation, Central Laboratory, The First Affiliated Hospital, Ningbo University School of Medicine, Ningbo, ChinaDepartment of Respiratory and Critical Care Medicine, Key Laboratory of Respiratory Disease of Ningbo, The First Affiliated Hospital of Ningbo University, Ningbo, ChinaDepartment of Engineering Mechanics, Zhejiang University, Hangzhou, ChinaThe advancement of drug delivery systems (DDSs) in recent decades has demonstrated significant potential in enhancing the efficacy of pharmacological agents. Despite the approval of certain DDSs for clinical use, challenges such as rapid clearance from circulation, toxic accumulation in the body, and ineffective targeted delivery persist as obstacles to successful clinical application. Blood cell-based DDSs have emerged as a popular strategy for drug administration, offering enhanced biocompatibility, stability, and prolonged circulation. These DDSs are well-suited for systemic drug delivery and have played a crucial role in formulating optimal drug combinations for treating a variety of diseases in both preclinical studies and clinical trials. This review focuses on recent advancements and applications of DDSs utilizing blood cells and their membrane-derived microvesicles. It addresses the current therapeutic applications of blood cell-based DDSs at the organ and tissue levels, highlighting their successful deployment at the cellular level. Furthermore, it explores the mechanisms of cellular uptake of drug delivery vectors at the subcellular level. Additionally, the review discusses the opportunities and challenges associated with these DDSs.https://www.tandfonline.com/doi/10.1080/10717544.2024.2425156Drug deliverydrug carrierblood cellblood flowcell membrane-derived microvesiclecellular uptake |
| spellingShingle | Andong He Yuye Huang Chao Cao Xuejin Li Advances in drug delivery systems utilizing blood cells and their membrane-derived microvesicles Drug Delivery Drug delivery drug carrier blood cell blood flow cell membrane-derived microvesicle cellular uptake |
| title | Advances in drug delivery systems utilizing blood cells and their membrane-derived microvesicles |
| title_full | Advances in drug delivery systems utilizing blood cells and their membrane-derived microvesicles |
| title_fullStr | Advances in drug delivery systems utilizing blood cells and their membrane-derived microvesicles |
| title_full_unstemmed | Advances in drug delivery systems utilizing blood cells and their membrane-derived microvesicles |
| title_short | Advances in drug delivery systems utilizing blood cells and their membrane-derived microvesicles |
| title_sort | advances in drug delivery systems utilizing blood cells and their membrane derived microvesicles |
| topic | Drug delivery drug carrier blood cell blood flow cell membrane-derived microvesicle cellular uptake |
| url | https://www.tandfonline.com/doi/10.1080/10717544.2024.2425156 |
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