Gene therapy for hearing loss: challenges and the promise of cellular plasticity and epigenetic modulation
Hearing loss can profoundly impact an individual’s quality of life, affecting communication, social interactions, and overall well-being. Many people with hearing impairment report feelings of isolation, frustration, and decreased confidence in social settings, which can lead to withdrawal from acti...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-12-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2024.1511938/full |
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| _version_ | 1850062303751307264 |
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| author | Samprita Das Uri Manor |
| author_facet | Samprita Das Uri Manor |
| author_sort | Samprita Das |
| collection | DOAJ |
| description | Hearing loss can profoundly impact an individual’s quality of life, affecting communication, social interactions, and overall well-being. Many people with hearing impairment report feelings of isolation, frustration, and decreased confidence in social settings, which can lead to withdrawal from activities they once enjoyed. Genetics plays a significant role in congenital hearing loss, accounting for approximately half of all cases. While gene therapy holds immense promise for restoring hearing function in cases of hereditary hearing loss (HHL), current methods face certain challenges that must be overcome to successfully develop therapeutic approaches. This review will explore these challenges and offer a perspective on how epigenetic modulation has the potential to address them, potentially revolutionizing the treatment of genetic hearing disorders. |
| format | Article |
| id | doaj-art-99c96aaab14c458bae03fa97493ee76e |
| institution | DOAJ |
| issn | 1664-2295 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj-art-99c96aaab14c458bae03fa97493ee76e2025-08-20T02:49:57ZengFrontiers Media S.A.Frontiers in Neurology1664-22952024-12-011510.3389/fneur.2024.15119381511938Gene therapy for hearing loss: challenges and the promise of cellular plasticity and epigenetic modulationSamprita DasUri ManorHearing loss can profoundly impact an individual’s quality of life, affecting communication, social interactions, and overall well-being. Many people with hearing impairment report feelings of isolation, frustration, and decreased confidence in social settings, which can lead to withdrawal from activities they once enjoyed. Genetics plays a significant role in congenital hearing loss, accounting for approximately half of all cases. While gene therapy holds immense promise for restoring hearing function in cases of hereditary hearing loss (HHL), current methods face certain challenges that must be overcome to successfully develop therapeutic approaches. This review will explore these challenges and offer a perspective on how epigenetic modulation has the potential to address them, potentially revolutionizing the treatment of genetic hearing disorders.https://www.frontiersin.org/articles/10.3389/fneur.2024.1511938/fullhearing lossgene therapypartial reprogrammingepigeneticsadeno-associated virusHDAC inhibitors |
| spellingShingle | Samprita Das Uri Manor Gene therapy for hearing loss: challenges and the promise of cellular plasticity and epigenetic modulation Frontiers in Neurology hearing loss gene therapy partial reprogramming epigenetics adeno-associated virus HDAC inhibitors |
| title | Gene therapy for hearing loss: challenges and the promise of cellular plasticity and epigenetic modulation |
| title_full | Gene therapy for hearing loss: challenges and the promise of cellular plasticity and epigenetic modulation |
| title_fullStr | Gene therapy for hearing loss: challenges and the promise of cellular plasticity and epigenetic modulation |
| title_full_unstemmed | Gene therapy for hearing loss: challenges and the promise of cellular plasticity and epigenetic modulation |
| title_short | Gene therapy for hearing loss: challenges and the promise of cellular plasticity and epigenetic modulation |
| title_sort | gene therapy for hearing loss challenges and the promise of cellular plasticity and epigenetic modulation |
| topic | hearing loss gene therapy partial reprogramming epigenetics adeno-associated virus HDAC inhibitors |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2024.1511938/full |
| work_keys_str_mv | AT sampritadas genetherapyforhearinglosschallengesandthepromiseofcellularplasticityandepigeneticmodulation AT urimanor genetherapyforhearinglosschallengesandthepromiseofcellularplasticityandepigeneticmodulation |