Introducing heat-not-burn tobacco improves hematocrit and cigarette smoking-related symptoms in patients with smokers' polycythemia and polycythemia vera.
Cigarette smoking induces relative and absolute erythrocytosis (smokers' polycythemia). In patients with smokers' polycythemia complicated by chronic obstructive pulmonary disease, the incidence and mortality rate of pulmonary embolism increase. Therefore, improving erythrocytosis by smoki...
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| Language: | English |
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Public Library of Science (PLoS)
2025-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0323437 |
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| author | Kazuhide Iizuka Yoshikazu Iizuka Shun Ito Toshihide Endo Hironao Nukariya Yuichi Takeuchi Takashi Koike Kazuya Kurihara Hiromichi Takahashi Masaru Nakagawa Takashi Hamada Shimon Ohtake Noriyoshi Iriyama Katsuhiro Miura Tomohiro Nakayama Yoshihiro Hatta Hideki Nakamura Norio Komatsu |
| author_facet | Kazuhide Iizuka Yoshikazu Iizuka Shun Ito Toshihide Endo Hironao Nukariya Yuichi Takeuchi Takashi Koike Kazuya Kurihara Hiromichi Takahashi Masaru Nakagawa Takashi Hamada Shimon Ohtake Noriyoshi Iriyama Katsuhiro Miura Tomohiro Nakayama Yoshihiro Hatta Hideki Nakamura Norio Komatsu |
| author_sort | Kazuhide Iizuka |
| collection | DOAJ |
| description | Cigarette smoking induces relative and absolute erythrocytosis (smokers' polycythemia). In patients with smokers' polycythemia complicated by chronic obstructive pulmonary disease, the incidence and mortality rate of pulmonary embolism increase. Therefore, improving erythrocytosis by smoking cessation is important; however, smoking cessation is often difficult to achieve. This study investigated the influence of introducing heat-not-burn tobacco in patients with smokers' polycythemia. Fifteen smokers with erythrocytosis were diagnosed with smokers' polycythemia (n = 13) or polycythemia vera (n = 2) groups. The patients selected a switch to heat-not-burn (HNB) tobacco or smoking cessation, and the subsequent changes in hematological data and symptoms were evaluated. Eight patients with smokers' polycythemia and two with polycythemia vera selected a switch to HNB tobacco, and the other five patients with smokers' polycythemia selected smoking cessation. In both the HNB tobacco and smoking cessation groups, all patients showed improved hematocrit (Hct) and sputum volume and ameliorated numbness, headache, and vertigo. In the patients with smokers' polycythemia, Hct of the HNB tobacco group was equivalent to that in the patients with smoking cessation group (47.51 ± 3.48% vs. 45.63 ± 2.79%, P = 0.605). Introduction of HNB tobacco may be useful for reducing erythrocytosis in smokers for whom smoking cessation is difficult. |
| format | Article |
| id | doaj-art-99c73de9e54c48a78309c4869d54021e |
| institution | OA Journals |
| issn | 1932-6203 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-99c73de9e54c48a78309c4869d54021e2025-08-20T02:33:44ZengPublic Library of Science (PLoS)PLoS ONE1932-62032025-01-01205e032343710.1371/journal.pone.0323437Introducing heat-not-burn tobacco improves hematocrit and cigarette smoking-related symptoms in patients with smokers' polycythemia and polycythemia vera.Kazuhide IizukaYoshikazu IizukaShun ItoToshihide EndoHironao NukariyaYuichi TakeuchiTakashi KoikeKazuya KuriharaHiromichi TakahashiMasaru NakagawaTakashi HamadaShimon OhtakeNoriyoshi IriyamaKatsuhiro MiuraTomohiro NakayamaYoshihiro HattaHideki NakamuraNorio KomatsuCigarette smoking induces relative and absolute erythrocytosis (smokers' polycythemia). In patients with smokers' polycythemia complicated by chronic obstructive pulmonary disease, the incidence and mortality rate of pulmonary embolism increase. Therefore, improving erythrocytosis by smoking cessation is important; however, smoking cessation is often difficult to achieve. This study investigated the influence of introducing heat-not-burn tobacco in patients with smokers' polycythemia. Fifteen smokers with erythrocytosis were diagnosed with smokers' polycythemia (n = 13) or polycythemia vera (n = 2) groups. The patients selected a switch to heat-not-burn (HNB) tobacco or smoking cessation, and the subsequent changes in hematological data and symptoms were evaluated. Eight patients with smokers' polycythemia and two with polycythemia vera selected a switch to HNB tobacco, and the other five patients with smokers' polycythemia selected smoking cessation. In both the HNB tobacco and smoking cessation groups, all patients showed improved hematocrit (Hct) and sputum volume and ameliorated numbness, headache, and vertigo. In the patients with smokers' polycythemia, Hct of the HNB tobacco group was equivalent to that in the patients with smoking cessation group (47.51 ± 3.48% vs. 45.63 ± 2.79%, P = 0.605). Introduction of HNB tobacco may be useful for reducing erythrocytosis in smokers for whom smoking cessation is difficult.https://doi.org/10.1371/journal.pone.0323437 |
| spellingShingle | Kazuhide Iizuka Yoshikazu Iizuka Shun Ito Toshihide Endo Hironao Nukariya Yuichi Takeuchi Takashi Koike Kazuya Kurihara Hiromichi Takahashi Masaru Nakagawa Takashi Hamada Shimon Ohtake Noriyoshi Iriyama Katsuhiro Miura Tomohiro Nakayama Yoshihiro Hatta Hideki Nakamura Norio Komatsu Introducing heat-not-burn tobacco improves hematocrit and cigarette smoking-related symptoms in patients with smokers' polycythemia and polycythemia vera. PLoS ONE |
| title | Introducing heat-not-burn tobacco improves hematocrit and cigarette smoking-related symptoms in patients with smokers' polycythemia and polycythemia vera. |
| title_full | Introducing heat-not-burn tobacco improves hematocrit and cigarette smoking-related symptoms in patients with smokers' polycythemia and polycythemia vera. |
| title_fullStr | Introducing heat-not-burn tobacco improves hematocrit and cigarette smoking-related symptoms in patients with smokers' polycythemia and polycythemia vera. |
| title_full_unstemmed | Introducing heat-not-burn tobacco improves hematocrit and cigarette smoking-related symptoms in patients with smokers' polycythemia and polycythemia vera. |
| title_short | Introducing heat-not-burn tobacco improves hematocrit and cigarette smoking-related symptoms in patients with smokers' polycythemia and polycythemia vera. |
| title_sort | introducing heat not burn tobacco improves hematocrit and cigarette smoking related symptoms in patients with smokers polycythemia and polycythemia vera |
| url | https://doi.org/10.1371/journal.pone.0323437 |
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