In-silico analysis of CYP1A2 (cytochrome P450 1A2) missense mutations: Implications for pharmacogenetics

In-silico analysis of CYP1A2 (cytochrome P450 1A2) missense mutations: Implications for pharmacogenetics

Cytochrome P450 1A2 (CYP1A2) is a key hepatic enzyme involved in the metabolism of a wide array of drugs and endogenous compounds. Variations in the CYP1A2 gene, specifically single nucleotide polymorphisms (SNPs), can significantly influence its enzymatic activity and individual drug metabolism whi...

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Bibliographic Details
Main Authors: Yasamin Khiabani, Nazanin Gholampour-Faroji, Habib Rezanejad, Mohammad Ehsan Taghavizadeh Yazdi, Razieh Farazmand, Aliakbar Haddad-Mashadrizeh
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:Heliyon
Subjects:
CYP1A2
Genetic variation
nsSNPs
Drug administration
Active-site cavity
Simulation
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844025013362
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