In-silico analysis of CYP1A2 (cytochrome P450 1A2) missense mutations: Implications for pharmacogenetics

In-silico analysis of CYP1A2 (cytochrome P450 1A2) missense mutations: Implications for pharmacogenetics

Cytochrome P450 1A2 (CYP1A2) is a key hepatic enzyme involved in the metabolism of a wide array of drugs and endogenous compounds. Variations in the CYP1A2 gene, specifically single nucleotide polymorphisms (SNPs), can significantly influence its enzymatic activity and individual drug metabolism whi...

Full description

Saved in:
Bibliographic Details
Main Authors: Yasamin Khiabani, Nazanin Gholampour-Faroji, Habib Rezanejad, Mohammad Ehsan Taghavizadeh Yazdi, Razieh Farazmand, Aliakbar Haddad-Mashadrizeh
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:Heliyon
Subjects:
CYP1A2
Genetic variation
nsSNPs
Drug administration
Active-site cavity
Simulation
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844025013362
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

http://www.sciencedirect.com/science/article/pii/S2405844025013362

Similar Items