Stable platelet production via the bypass pathway explains long-term hematopoietic stem cell reconstitution

Stable platelet production via the bypass pathway explains long-term hematopoietic stem cell reconstitution

Summary: In vivo differentiation pathways into several blood cell lineages of Hematopoietic stem cells (HSCs) remain challenging to track over time. Using data from single-cell transplantation assays and mathematical modeling, we examined HSC differentiation kinetics, including the myeloid bypass pa...

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Bibliographic Details
Main Authors: Shoya Iwanami, Toshiko Sato, Hiroshi Haeno, Longchen Xu, Keimyo Imamura, Jun Ooehara, Xun Lan, Hiromitsu Nakauchi, Shingo Iwami, Ryo Yamamoto
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:iScience
Subjects:
Stem cells research
Mathematical biosciences
Biological constraints
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004225008089
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