Targeting TP53TG1: a promising prognostic biomarker and therapeutic target for personalized cancer therapy
Abstract Tumor protein p53 target gene 1 (TP53TG1) is a significant long non-coding RNA (lncRNA) located on human chromosome 7q21.12, exhibiting dysregulated expression in several cancer tissues, and operates both as an oncogene and a tumor suppressor. TP53TG1 modulates gene expression by several me...
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| Format: | Article |
| Language: | English |
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Springer
2025-07-01
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| Series: | Discover Oncology |
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| Online Access: | https://doi.org/10.1007/s12672-025-03065-2 |
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| author | Haodong He |
| author_facet | Haodong He |
| author_sort | Haodong He |
| collection | DOAJ |
| description | Abstract Tumor protein p53 target gene 1 (TP53TG1) is a significant long non-coding RNA (lncRNA) located on human chromosome 7q21.12, exhibiting dysregulated expression in several cancer tissues, and operates both as an oncogene and a tumor suppressor. TP53TG1 modulates gene expression by several mechanisms, including “competitive RNA” activity, competitive miRNA binding, control of critical signaling pathways, and facilitation of epigenetic changes. TP53TG1 affects tumor proliferation, migration, invasion, and apoptosis through intricate mechanisms, modifies tumor cells resistance to therapies, influences the tumor immune microenvironment and metabolic reprogramming, and may present various avenues for clinical therapeutic intervention. Notwithstanding considerable advancements in comprehending the molecular function of TP53TG1, some challenges persist, especially regarding the efficient and targeted administration of TP53TG1-based therapeutics. Advanced RNA delivery technologies, including lipid nanoparticles (LNPs), sphingomyelin-based nanosystems, and polymer-based nanocarriers, have demonstrated the capacity to surmount these obstacles. This review aims to clarify the expression pattern of TP53TG1 in 10 malignant tumors, its biological relevance, its potential as a therapeutic target, and its importance in clinical applications, thereby offering a novel perspective on molecular targeting in cancer. In the future, integrating TP53TG1 with conventional medications may augment efficacy, offer personalized treatments, and eventually increase the prognosis for patients with aggressive or drug-resistant cancers. |
| format | Article |
| id | doaj-art-99bfe33eb4454bcd98a79ce2c5d53bce |
| institution | Kabale University |
| issn | 2730-6011 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Springer |
| record_format | Article |
| series | Discover Oncology |
| spelling | doaj-art-99bfe33eb4454bcd98a79ce2c5d53bce2025-08-20T03:42:55ZengSpringerDiscover Oncology2730-60112025-07-0116112410.1007/s12672-025-03065-2Targeting TP53TG1: a promising prognostic biomarker and therapeutic target for personalized cancer therapyHaodong He0Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy, China Three Gorges UniversityAbstract Tumor protein p53 target gene 1 (TP53TG1) is a significant long non-coding RNA (lncRNA) located on human chromosome 7q21.12, exhibiting dysregulated expression in several cancer tissues, and operates both as an oncogene and a tumor suppressor. TP53TG1 modulates gene expression by several mechanisms, including “competitive RNA” activity, competitive miRNA binding, control of critical signaling pathways, and facilitation of epigenetic changes. TP53TG1 affects tumor proliferation, migration, invasion, and apoptosis through intricate mechanisms, modifies tumor cells resistance to therapies, influences the tumor immune microenvironment and metabolic reprogramming, and may present various avenues for clinical therapeutic intervention. Notwithstanding considerable advancements in comprehending the molecular function of TP53TG1, some challenges persist, especially regarding the efficient and targeted administration of TP53TG1-based therapeutics. Advanced RNA delivery technologies, including lipid nanoparticles (LNPs), sphingomyelin-based nanosystems, and polymer-based nanocarriers, have demonstrated the capacity to surmount these obstacles. This review aims to clarify the expression pattern of TP53TG1 in 10 malignant tumors, its biological relevance, its potential as a therapeutic target, and its importance in clinical applications, thereby offering a novel perspective on molecular targeting in cancer. In the future, integrating TP53TG1 with conventional medications may augment efficacy, offer personalized treatments, and eventually increase the prognosis for patients with aggressive or drug-resistant cancers.https://doi.org/10.1007/s12672-025-03065-2LncRNATP53TG1CancersBiomarkerPrognosisTargeted therapy |
| spellingShingle | Haodong He Targeting TP53TG1: a promising prognostic biomarker and therapeutic target for personalized cancer therapy Discover Oncology LncRNA TP53TG1 Cancers Biomarker Prognosis Targeted therapy |
| title | Targeting TP53TG1: a promising prognostic biomarker and therapeutic target for personalized cancer therapy |
| title_full | Targeting TP53TG1: a promising prognostic biomarker and therapeutic target for personalized cancer therapy |
| title_fullStr | Targeting TP53TG1: a promising prognostic biomarker and therapeutic target for personalized cancer therapy |
| title_full_unstemmed | Targeting TP53TG1: a promising prognostic biomarker and therapeutic target for personalized cancer therapy |
| title_short | Targeting TP53TG1: a promising prognostic biomarker and therapeutic target for personalized cancer therapy |
| title_sort | targeting tp53tg1 a promising prognostic biomarker and therapeutic target for personalized cancer therapy |
| topic | LncRNA TP53TG1 Cancers Biomarker Prognosis Targeted therapy |
| url | https://doi.org/10.1007/s12672-025-03065-2 |
| work_keys_str_mv | AT haodonghe targetingtp53tg1apromisingprognosticbiomarkerandtherapeutictargetforpersonalizedcancertherapy |