Treatment of Advanced Parkinson's Disease

Patients at late stage Parkinson's disease (PD) develop several motor and nonmotor complications, which dramatically impair their quality of life. These complications include motor fluctuations, dyskinesia, unpredictable or absent response to medications, falls, dysautonomia, dementia, hallucin...

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Main Authors: Sara Varanese, Zoe Birnbaum, Roger Rossi, Alessandro Di Rocco
Format: Article
Language:English
Published: Wiley 2010-01-01
Series:Parkinson's Disease
Online Access:http://dx.doi.org/10.4061/2010/480260
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author Sara Varanese
Zoe Birnbaum
Roger Rossi
Alessandro Di Rocco
author_facet Sara Varanese
Zoe Birnbaum
Roger Rossi
Alessandro Di Rocco
author_sort Sara Varanese
collection DOAJ
description Patients at late stage Parkinson's disease (PD) develop several motor and nonmotor complications, which dramatically impair their quality of life. These complications include motor fluctuations, dyskinesia, unpredictable or absent response to medications, falls, dysautonomia, dementia, hallucinations, sleep disorders, depression, and psychosis. The therapeutic management should be driven by the attempt to create a balance between benefit and side effects of the pharmacological treatments available. Supportive care, including physical and rehabilitative interventions, speech therapy, occupational therapy, and nursing care, has a key role in the late stage of disease. In this review we discuss the several complications experienced by advance PD patients and their management. The importance of an integrative approach, including both pharmacological and supportive interventions, is emphasized.
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series Parkinson's Disease
spelling doaj-art-99bfe32a91364a93878b5ac6122076f52025-02-03T05:59:42ZengWileyParkinson's Disease2042-00802010-01-01201010.4061/2010/480260480260Treatment of Advanced Parkinson's DiseaseSara Varanese0Zoe Birnbaum1Roger Rossi2Alessandro Di Rocco3New York University School of Medicine, Department of Neurology, Division of Movement Disorders, New York, NY 10016, USANew York University School of Medicine, Department of Neurology, Division of Movement Disorders, New York, NY 10016, USARobert Wood Johnson Medical School, Johnson Rehabilitation Institute, Edison, NJ 08818, USANew York University School of Medicine, Department of Neurology, Division of Movement Disorders, New York, NY 10016, USAPatients at late stage Parkinson's disease (PD) develop several motor and nonmotor complications, which dramatically impair their quality of life. These complications include motor fluctuations, dyskinesia, unpredictable or absent response to medications, falls, dysautonomia, dementia, hallucinations, sleep disorders, depression, and psychosis. The therapeutic management should be driven by the attempt to create a balance between benefit and side effects of the pharmacological treatments available. Supportive care, including physical and rehabilitative interventions, speech therapy, occupational therapy, and nursing care, has a key role in the late stage of disease. In this review we discuss the several complications experienced by advance PD patients and their management. The importance of an integrative approach, including both pharmacological and supportive interventions, is emphasized.http://dx.doi.org/10.4061/2010/480260
spellingShingle Sara Varanese
Zoe Birnbaum
Roger Rossi
Alessandro Di Rocco
Treatment of Advanced Parkinson's Disease
Parkinson's Disease
title Treatment of Advanced Parkinson's Disease
title_full Treatment of Advanced Parkinson's Disease
title_fullStr Treatment of Advanced Parkinson's Disease
title_full_unstemmed Treatment of Advanced Parkinson's Disease
title_short Treatment of Advanced Parkinson's Disease
title_sort treatment of advanced parkinson s disease
url http://dx.doi.org/10.4061/2010/480260
work_keys_str_mv AT saravaranese treatmentofadvancedparkinsonsdisease
AT zoebirnbaum treatmentofadvancedparkinsonsdisease
AT rogerrossi treatmentofadvancedparkinsonsdisease
AT alessandrodirocco treatmentofadvancedparkinsonsdisease