Age-Related Changes in Caudate Glucose Metabolism: Insights from Normative Modeling Study in Healthy Subjects
Background: As the global population ages, the prevalence of neurodegenerative conditions, such as Alzheimer’s disease (AD), Parkinson’s disease (PD), dementia with Lewy bodies, and frontotemporal dementia, continues to rise. Understanding the impact of aging on striatal glucose metabolism is pivota...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-01-01
|
| Series: | Metabolites |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2218-1989/15/2/67 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850231543527636992 |
|---|---|
| author | Zijing Zhang Yuchen Li Qi Xia Qing Yu Luqing Wei Guo-Rong Wu |
| author_facet | Zijing Zhang Yuchen Li Qi Xia Qing Yu Luqing Wei Guo-Rong Wu |
| author_sort | Zijing Zhang |
| collection | DOAJ |
| description | Background: As the global population ages, the prevalence of neurodegenerative conditions, such as Alzheimer’s disease (AD), Parkinson’s disease (PD), dementia with Lewy bodies, and frontotemporal dementia, continues to rise. Understanding the impact of aging on striatal glucose metabolism is pivotal in identifying potential biomarkers for the early detection of these disorders. Methods: We investigated age-related changes in striatal glucose metabolism using both region of interest (ROI)-based and voxel-wise correlation analyses. Additionally, we employed a normative modeling approach to establish age-related metabolic trajectories and assess individual deviations from these normative patterns. In vivo cerebral glucose metabolism was quantified using a molecular neuroimaging technique, <sup>18</sup>F-FDG PET. Results: Our results revealed significant negative correlations between age and glucose metabolism in the bilateral caudate. Furthermore, the normative modeling demonstrated a clear, progressive decline in caudate metabolism with advancing age, and the most pronounced reductions were observed in older individuals. Conclusions: These findings suggest that metabolic reductions in the caudate may serve as a sensitive biomarker for normal aging and offer valuable insights into the early stages of neurodegenerative diseases. Moreover, by establishing age-specific reference values for caudate glucose metabolism, the normative model provides a framework for detecting deviations from expected metabolic patterns, which may facilitate the early identification of metabolic alterations that could precede clinical symptoms of neurodegenerative processes. |
| format | Article |
| id | doaj-art-99bef0f2bdb8426fb7782f6cecb7fda4 |
| institution | OA Journals |
| issn | 2218-1989 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Metabolites |
| spelling | doaj-art-99bef0f2bdb8426fb7782f6cecb7fda42025-08-20T02:03:28ZengMDPI AGMetabolites2218-19892025-01-011526710.3390/metabo15020067Age-Related Changes in Caudate Glucose Metabolism: Insights from Normative Modeling Study in Healthy SubjectsZijing Zhang0Yuchen Li1Qi Xia2Qing Yu3Luqing Wei4Guo-Rong Wu5Key Laboratory of Cognition and Personality, Faculty of Psychology, Southwest University, Chongqing 400715, ChinaKey Laboratory of Cognition and Personality, Faculty of Psychology, Southwest University, Chongqing 400715, ChinaKey Laboratory of Cognition and Personality, Faculty of Psychology, Southwest University, Chongqing 400715, ChinaKey Laboratory of Cognition and Personality, Faculty of Psychology, Southwest University, Chongqing 400715, ChinaSchool of Psychology, Jiangxi Normal University, Nanchang 330022, ChinaKey Laboratory of Cognition and Personality, Faculty of Psychology, Southwest University, Chongqing 400715, ChinaBackground: As the global population ages, the prevalence of neurodegenerative conditions, such as Alzheimer’s disease (AD), Parkinson’s disease (PD), dementia with Lewy bodies, and frontotemporal dementia, continues to rise. Understanding the impact of aging on striatal glucose metabolism is pivotal in identifying potential biomarkers for the early detection of these disorders. Methods: We investigated age-related changes in striatal glucose metabolism using both region of interest (ROI)-based and voxel-wise correlation analyses. Additionally, we employed a normative modeling approach to establish age-related metabolic trajectories and assess individual deviations from these normative patterns. In vivo cerebral glucose metabolism was quantified using a molecular neuroimaging technique, <sup>18</sup>F-FDG PET. Results: Our results revealed significant negative correlations between age and glucose metabolism in the bilateral caudate. Furthermore, the normative modeling demonstrated a clear, progressive decline in caudate metabolism with advancing age, and the most pronounced reductions were observed in older individuals. Conclusions: These findings suggest that metabolic reductions in the caudate may serve as a sensitive biomarker for normal aging and offer valuable insights into the early stages of neurodegenerative diseases. Moreover, by establishing age-specific reference values for caudate glucose metabolism, the normative model provides a framework for detecting deviations from expected metabolic patterns, which may facilitate the early identification of metabolic alterations that could precede clinical symptoms of neurodegenerative processes.https://www.mdpi.com/2218-1989/15/2/67agingstriatal glucose metabolismcaudatenormative modeling |
| spellingShingle | Zijing Zhang Yuchen Li Qi Xia Qing Yu Luqing Wei Guo-Rong Wu Age-Related Changes in Caudate Glucose Metabolism: Insights from Normative Modeling Study in Healthy Subjects Metabolites aging striatal glucose metabolism caudate normative modeling |
| title | Age-Related Changes in Caudate Glucose Metabolism: Insights from Normative Modeling Study in Healthy Subjects |
| title_full | Age-Related Changes in Caudate Glucose Metabolism: Insights from Normative Modeling Study in Healthy Subjects |
| title_fullStr | Age-Related Changes in Caudate Glucose Metabolism: Insights from Normative Modeling Study in Healthy Subjects |
| title_full_unstemmed | Age-Related Changes in Caudate Glucose Metabolism: Insights from Normative Modeling Study in Healthy Subjects |
| title_short | Age-Related Changes in Caudate Glucose Metabolism: Insights from Normative Modeling Study in Healthy Subjects |
| title_sort | age related changes in caudate glucose metabolism insights from normative modeling study in healthy subjects |
| topic | aging striatal glucose metabolism caudate normative modeling |
| url | https://www.mdpi.com/2218-1989/15/2/67 |
| work_keys_str_mv | AT zijingzhang agerelatedchangesincaudateglucosemetabolisminsightsfromnormativemodelingstudyinhealthysubjects AT yuchenli agerelatedchangesincaudateglucosemetabolisminsightsfromnormativemodelingstudyinhealthysubjects AT qixia agerelatedchangesincaudateglucosemetabolisminsightsfromnormativemodelingstudyinhealthysubjects AT qingyu agerelatedchangesincaudateglucosemetabolisminsightsfromnormativemodelingstudyinhealthysubjects AT luqingwei agerelatedchangesincaudateglucosemetabolisminsightsfromnormativemodelingstudyinhealthysubjects AT guorongwu agerelatedchangesincaudateglucosemetabolisminsightsfromnormativemodelingstudyinhealthysubjects |