Biofunctional Excipients: Their Emerging Role in Overcoming the Inherent Poor Biopharmaceutical Characteristics of Drugs
<b>Background/Objectives:</b> With advancements in biomaterial sciences, biofunctional excipients have emerged to focus on solving issues with the drugs’ inherent biopharmaceutical characteristics such as poor solubility, permeability, in vivo dissolution, and effective targeting. These...
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| Format: | Article |
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MDPI AG
2025-05-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/17/5/598 |
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| author | Milad Reda Qelliny Wesam W. Mustafa Adel Al Fatease Ali H. Alamri Raid Alany Hamdy Abdelkader |
| author_facet | Milad Reda Qelliny Wesam W. Mustafa Adel Al Fatease Ali H. Alamri Raid Alany Hamdy Abdelkader |
| author_sort | Milad Reda Qelliny |
| collection | DOAJ |
| description | <b>Background/Objectives:</b> With advancements in biomaterial sciences, biofunctional excipients have emerged to focus on solving issues with the drugs’ inherent biopharmaceutical characteristics such as poor solubility, permeability, in vivo dissolution, and effective targeting. These advanced excipients significantly impact drug solubility, dissolution rates, absorption rates, permeation rates, penetration ability, targeting ability, and pharmacokinetic profiles. <b>Methods:</b> A literature review of recently published articles was prepared. Data were collected using scientific search engines. This review provided a detailed discussion of various biofunctional excipients including smart polymers, targeted polymers, bioadhesive polymers, lipids, amino acids, cyclodextrins, and biosurfactants. Each category was discussed in detail concerning its biofunctional applications, the mechanisms underlying these biofunctions, and examples of their effects on drug performance. <b>Results:</b> The data obtained indicated that the rapid advances in the manufacturing of pharmaceutical excipients have resulted in the development of a diverse array of smart or intelligent excipients that play a crucial role in enhancing inherent poor biopharmaceutical characteristics. <b>Conclusions:</b> These advancements have also facilitated the development of various drug delivery systems, including immediate, controlled, sustained, and targeted drug release systems. Also, numerous nano-based delivery systems have emerged utilizing the newly produced excipients. |
| format | Article |
| id | doaj-art-99b97dd668dc4e79aa9f5fd3f36cc232 |
| institution | DOAJ |
| issn | 1999-4923 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj-art-99b97dd668dc4e79aa9f5fd3f36cc2322025-08-20T03:14:32ZengMDPI AGPharmaceutics1999-49232025-05-0117559810.3390/pharmaceutics17050598Biofunctional Excipients: Their Emerging Role in Overcoming the Inherent Poor Biopharmaceutical Characteristics of DrugsMilad Reda Qelliny0Wesam W. Mustafa1Adel Al Fatease2Ali H. Alamri3Raid Alany4Hamdy Abdelkader5Department of Pharmaceutics, Faculty of Pharmacy, Minia University, Minia 61519, EgyptDepartment of Pharmaceutics, College of Pharmacy, Al-Mustafa University, Baghdad 996X+JXC, IraqDepartment of Pharmaceutics, College of Pharmacy, King Khalid University, Abha 62529, Saudi ArabiaDepartment of Pharmaceutics, College of Pharmacy, King Khalid University, Abha 62529, Saudi ArabiaSchool of Pharmacy, Kingston University London, Kingston Upon Thames KT1 2EE, UKDepartment of Pharmaceutics, College of Pharmacy, King Khalid University, Abha 62529, Saudi Arabia<b>Background/Objectives:</b> With advancements in biomaterial sciences, biofunctional excipients have emerged to focus on solving issues with the drugs’ inherent biopharmaceutical characteristics such as poor solubility, permeability, in vivo dissolution, and effective targeting. These advanced excipients significantly impact drug solubility, dissolution rates, absorption rates, permeation rates, penetration ability, targeting ability, and pharmacokinetic profiles. <b>Methods:</b> A literature review of recently published articles was prepared. Data were collected using scientific search engines. This review provided a detailed discussion of various biofunctional excipients including smart polymers, targeted polymers, bioadhesive polymers, lipids, amino acids, cyclodextrins, and biosurfactants. Each category was discussed in detail concerning its biofunctional applications, the mechanisms underlying these biofunctions, and examples of their effects on drug performance. <b>Results:</b> The data obtained indicated that the rapid advances in the manufacturing of pharmaceutical excipients have resulted in the development of a diverse array of smart or intelligent excipients that play a crucial role in enhancing inherent poor biopharmaceutical characteristics. <b>Conclusions:</b> These advancements have also facilitated the development of various drug delivery systems, including immediate, controlled, sustained, and targeted drug release systems. Also, numerous nano-based delivery systems have emerged utilizing the newly produced excipients.https://www.mdpi.com/1999-4923/17/5/598pharmaceutical excipientsbiofunctional excipientssmart polymerslipidsamino acidscyclodextrins |
| spellingShingle | Milad Reda Qelliny Wesam W. Mustafa Adel Al Fatease Ali H. Alamri Raid Alany Hamdy Abdelkader Biofunctional Excipients: Their Emerging Role in Overcoming the Inherent Poor Biopharmaceutical Characteristics of Drugs Pharmaceutics pharmaceutical excipients biofunctional excipients smart polymers lipids amino acids cyclodextrins |
| title | Biofunctional Excipients: Their Emerging Role in Overcoming the Inherent Poor Biopharmaceutical Characteristics of Drugs |
| title_full | Biofunctional Excipients: Their Emerging Role in Overcoming the Inherent Poor Biopharmaceutical Characteristics of Drugs |
| title_fullStr | Biofunctional Excipients: Their Emerging Role in Overcoming the Inherent Poor Biopharmaceutical Characteristics of Drugs |
| title_full_unstemmed | Biofunctional Excipients: Their Emerging Role in Overcoming the Inherent Poor Biopharmaceutical Characteristics of Drugs |
| title_short | Biofunctional Excipients: Their Emerging Role in Overcoming the Inherent Poor Biopharmaceutical Characteristics of Drugs |
| title_sort | biofunctional excipients their emerging role in overcoming the inherent poor biopharmaceutical characteristics of drugs |
| topic | pharmaceutical excipients biofunctional excipients smart polymers lipids amino acids cyclodextrins |
| url | https://www.mdpi.com/1999-4923/17/5/598 |
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