Quantitative comparison of CSVD imaging markers between patients with possible amyloid small vessel disease and with non-amyloid small vessel disease
The spatial distribution patterns of cerebral microbleeds are associated with different types of cerebral small vessel disease (CSVD). This study aims to examine the disparities in brain imaging markers of CSVD among patients diagnosed with possible amyloid and non-amyloid small vessel disease. The...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-01-01
|
| Series: | NeuroImage: Clinical |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213158224001220 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850266299016413184 |
|---|---|
| author | Chun-Qiang Lu Ying Liu Jia-Rong Huang Meng-Shuang Li Yan-Shuang Wang Yan Gu Di Chang |
| author_facet | Chun-Qiang Lu Ying Liu Jia-Rong Huang Meng-Shuang Li Yan-Shuang Wang Yan Gu Di Chang |
| author_sort | Chun-Qiang Lu |
| collection | DOAJ |
| description | The spatial distribution patterns of cerebral microbleeds are associated with different types of cerebral small vessel disease (CSVD). This study aims to examine the disparities in brain imaging markers of CSVD among patients diagnosed with possible amyloid and non-amyloid small vessel disease. The head MR scans including susceptibility-weighted imaging (SWI) sequences from 351 patients at our institute were collected for analysis. CSVD imaging markers were quantified or graded across various CSVD dimensions in the patient images. Patients were categorized into the cerebral amyloid angiopathy group (CAA), hypertensive arteriopathy group (HA), or mixed small vessel disease group (Mixed), based on the spatial distribution of microbleeds. White matter lesions (WML) were segmented using an artificial neural network and assessed via a voxel-wise approach. Significant differences were observed among the three groups in several indices: microbleed count, lacune count at the centrum semiovale and basal ganglia levels, grade of enlarged perivascular space (EPVS) at the basal ganglia, and white matter lesion volume. These indices were substantially higher in the Mixed group compared to the other groups. Additionally, the incidences of cerebral hemorrhages (χ2 = 7.659, P = 0.006) and recent small subcortical infarcts (χ2 = 4.660, P = 0.031) were significantly more frequent in the HA group than in the CAA group. These results indicate that mixed spatial distribution patterns of microbleeds demonstrated the highest burden of cerebral small vessel disease. Microbleeds located in the deep brain regions were associated with a higher incidence of recent small subcortical infarcts and cerebral hemorrhages compared to those in the cortical areas. |
| format | Article |
| id | doaj-art-99b76c66ad64486bb820a9de0745dffc |
| institution | OA Journals |
| issn | 2213-1582 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage: Clinical |
| spelling | doaj-art-99b76c66ad64486bb820a9de0745dffc2025-08-20T01:54:12ZengElsevierNeuroImage: Clinical2213-15822024-01-014410368110.1016/j.nicl.2024.103681Quantitative comparison of CSVD imaging markers between patients with possible amyloid small vessel disease and with non-amyloid small vessel diseaseChun-Qiang Lu0Ying Liu1Jia-Rong Huang2Meng-Shuang Li3Yan-Shuang Wang4Yan Gu5Di Chang6Nurturing Center of Jiangsu Province for State Laboratory of AI Imaging & Interventional Radiology, Department of Radiology, Zhongda Hospital, Medical School of Southeast University, 87 Dingjiaqiao Road, Nanjing, Jiangsu 210009, China; Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Suzhou, Jiangsu 215128, ChinaDepartment of Radiology, The First Affiliated Hospital of Kangda College of Nanjing Medical University, Lianyungang, Jiangsu 222000, China; The First Peoples Hospital of Lianyungang, Lianyungang, Jiangsu 222000, ChinaDepartment of Radiology, The First Affiliated Hospital of Kangda College of Nanjing Medical University, Lianyungang, Jiangsu 222000, China; The First Peoples Hospital of Lianyungang, Lianyungang, Jiangsu 222000, ChinaDepartment of Radiology, The First Affiliated Hospital of Kangda College of Nanjing Medical University, Lianyungang, Jiangsu 222000, China; The First Peoples Hospital of Lianyungang, Lianyungang, Jiangsu 222000, ChinaDepartment of Radiology, The First Affiliated Hospital of Kangda College of Nanjing Medical University, Lianyungang, Jiangsu 222000, China; The First Peoples Hospital of Lianyungang, Lianyungang, Jiangsu 222000, ChinaDepartment of Radiology, The First Affiliated Hospital of Kangda College of Nanjing Medical University, Lianyungang, Jiangsu 222000, China; The First Peoples Hospital of Lianyungang, Lianyungang, Jiangsu 222000, China; Corresponding authors at: Nurturing Center of Jiangsu Province for State Laboratory of AI Imaging & Interventional Radiology, Department of Radiology, Zhongda Hospital, Medical School of Southeast University, 87 Dingjiaqiao Road, Nanjing, Jiangsu 210009, China (D. Chang).Nurturing Center of Jiangsu Province for State Laboratory of AI Imaging & Interventional Radiology, Department of Radiology, Zhongda Hospital, Medical School of Southeast University, 87 Dingjiaqiao Road, Nanjing, Jiangsu 210009, China; Corresponding authors at: Nurturing Center of Jiangsu Province for State Laboratory of AI Imaging & Interventional Radiology, Department of Radiology, Zhongda Hospital, Medical School of Southeast University, 87 Dingjiaqiao Road, Nanjing, Jiangsu 210009, China (D. Chang).The spatial distribution patterns of cerebral microbleeds are associated with different types of cerebral small vessel disease (CSVD). This study aims to examine the disparities in brain imaging markers of CSVD among patients diagnosed with possible amyloid and non-amyloid small vessel disease. The head MR scans including susceptibility-weighted imaging (SWI) sequences from 351 patients at our institute were collected for analysis. CSVD imaging markers were quantified or graded across various CSVD dimensions in the patient images. Patients were categorized into the cerebral amyloid angiopathy group (CAA), hypertensive arteriopathy group (HA), or mixed small vessel disease group (Mixed), based on the spatial distribution of microbleeds. White matter lesions (WML) were segmented using an artificial neural network and assessed via a voxel-wise approach. Significant differences were observed among the three groups in several indices: microbleed count, lacune count at the centrum semiovale and basal ganglia levels, grade of enlarged perivascular space (EPVS) at the basal ganglia, and white matter lesion volume. These indices were substantially higher in the Mixed group compared to the other groups. Additionally, the incidences of cerebral hemorrhages (χ2 = 7.659, P = 0.006) and recent small subcortical infarcts (χ2 = 4.660, P = 0.031) were significantly more frequent in the HA group than in the CAA group. These results indicate that mixed spatial distribution patterns of microbleeds demonstrated the highest burden of cerebral small vessel disease. Microbleeds located in the deep brain regions were associated with a higher incidence of recent small subcortical infarcts and cerebral hemorrhages compared to those in the cortical areas.http://www.sciencedirect.com/science/article/pii/S2213158224001220Cerebral small vessel diseaseAmyloid small vessel diseaseWhite matter lesionMicrobleedsMagnetic resonance imaging |
| spellingShingle | Chun-Qiang Lu Ying Liu Jia-Rong Huang Meng-Shuang Li Yan-Shuang Wang Yan Gu Di Chang Quantitative comparison of CSVD imaging markers between patients with possible amyloid small vessel disease and with non-amyloid small vessel disease NeuroImage: Clinical Cerebral small vessel disease Amyloid small vessel disease White matter lesion Microbleeds Magnetic resonance imaging |
| title | Quantitative comparison of CSVD imaging markers between patients with possible amyloid small vessel disease and with non-amyloid small vessel disease |
| title_full | Quantitative comparison of CSVD imaging markers between patients with possible amyloid small vessel disease and with non-amyloid small vessel disease |
| title_fullStr | Quantitative comparison of CSVD imaging markers between patients with possible amyloid small vessel disease and with non-amyloid small vessel disease |
| title_full_unstemmed | Quantitative comparison of CSVD imaging markers between patients with possible amyloid small vessel disease and with non-amyloid small vessel disease |
| title_short | Quantitative comparison of CSVD imaging markers between patients with possible amyloid small vessel disease and with non-amyloid small vessel disease |
| title_sort | quantitative comparison of csvd imaging markers between patients with possible amyloid small vessel disease and with non amyloid small vessel disease |
| topic | Cerebral small vessel disease Amyloid small vessel disease White matter lesion Microbleeds Magnetic resonance imaging |
| url | http://www.sciencedirect.com/science/article/pii/S2213158224001220 |
| work_keys_str_mv | AT chunqianglu quantitativecomparisonofcsvdimagingmarkersbetweenpatientswithpossibleamyloidsmallvesseldiseaseandwithnonamyloidsmallvesseldisease AT yingliu quantitativecomparisonofcsvdimagingmarkersbetweenpatientswithpossibleamyloidsmallvesseldiseaseandwithnonamyloidsmallvesseldisease AT jiaronghuang quantitativecomparisonofcsvdimagingmarkersbetweenpatientswithpossibleamyloidsmallvesseldiseaseandwithnonamyloidsmallvesseldisease AT mengshuangli quantitativecomparisonofcsvdimagingmarkersbetweenpatientswithpossibleamyloidsmallvesseldiseaseandwithnonamyloidsmallvesseldisease AT yanshuangwang quantitativecomparisonofcsvdimagingmarkersbetweenpatientswithpossibleamyloidsmallvesseldiseaseandwithnonamyloidsmallvesseldisease AT yangu quantitativecomparisonofcsvdimagingmarkersbetweenpatientswithpossibleamyloidsmallvesseldiseaseandwithnonamyloidsmallvesseldisease AT dichang quantitativecomparisonofcsvdimagingmarkersbetweenpatientswithpossibleamyloidsmallvesseldiseaseandwithnonamyloidsmallvesseldisease |