Elevated SAMD3 expression in T cells predicts improved survival in pancreatic ductal adenocarcinoma patients

Elevated SAMD3 expression in T cells predicts improved survival in pancreatic ductal adenocarcinoma patients

Abstract Objective Pancreatic ductal adenocarcinoma (PDAC) has an immune-suppressive tumor microenvironment that contributes to resistance to immunotherapy. This study aimed to demonstrate that elevated sterile alpha motif domain-containing protein 3 (SAMD3) expression in effector CD8+ T cells was a...

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Bibliographic Details
Main Authors: Lingyi Fu, Enliang Zhou, Shuo Li, Ziteng Li, Liyan Wu, Xinxin Zhou, Lang Tian, Bokang Cui
Format: Article
Language:English
Published: Springer 2025-02-01
Series:Cancer Immunology, Immunotherapy
Subjects:
Pancreatic ductal adenocarcinoma
T cell
SAMD3
Single-cell RNA sequencing
Online Access:https://doi.org/10.1007/s00262-025-03948-x
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