Macrophage-derived extracellular vesicles as new players in chronic non-communicable diseases
Macrophages are innate immune cells present in all tissues and play an important role in almost all aspects of the biology of living organisms. Extracellular vesicles (EVs) are released by cells and transport their contents (micro RNAs, mRNA, proteins, and long noncoding RNAs) to nearby or distant c...
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Frontiers Media S.A.
2025-01-01
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Series: | Frontiers in Immunology |
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Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1479330/full |
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author | Fengjuan Lin Huiyu Luo Jiexian Wang Qing Li Longying Zha |
author_facet | Fengjuan Lin Huiyu Luo Jiexian Wang Qing Li Longying Zha |
author_sort | Fengjuan Lin |
collection | DOAJ |
description | Macrophages are innate immune cells present in all tissues and play an important role in almost all aspects of the biology of living organisms. Extracellular vesicles (EVs) are released by cells and transport their contents (micro RNAs, mRNA, proteins, and long noncoding RNAs) to nearby or distant cells for cell-to-cell communication. Numerous studies have shown that macrophage-derived extracellular vesicles (M-EVs) and their contents play an important role in a variety of diseases and show great potential as biomarkers, therapeutics, and drug delivery vehicles for diseases. This article reviews the biological functions and mechanisms of M-EVs and their contents in chronic non-communicable diseases such as cardiovascular diseases, metabolic diseases, cancer, inflammatory diseases and bone-related diseases. In addition, the potential application of M-EVs as drug delivery systems for various diseases have been summarized. |
format | Article |
id | doaj-art-99b12f502a2b43c4aa6ecdae74f94167 |
institution | Kabale University |
issn | 1664-3224 |
language | English |
publishDate | 2025-01-01 |
publisher | Frontiers Media S.A. |
record_format | Article |
series | Frontiers in Immunology |
spelling | doaj-art-99b12f502a2b43c4aa6ecdae74f941672025-01-17T05:10:40ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-01-011510.3389/fimmu.2024.14793301479330Macrophage-derived extracellular vesicles as new players in chronic non-communicable diseasesFengjuan Lin0Huiyu Luo1Jiexian Wang2Qing Li3Longying Zha4Department of Nutrition and Food Hygiene, Guangdong Provincial Key Laboratory of Tropical Disease Research, National Medical Products Administration (NMPA) Key Laboratory for Safety Evaluation of Cosmetics, School of Public Health, Southern Medical University, Guangzhou, Guangdong, ChinaDepartment of Nutrition and Food Hygiene, Guangdong Provincial Key Laboratory of Tropical Disease Research, National Medical Products Administration (NMPA) Key Laboratory for Safety Evaluation of Cosmetics, School of Public Health, Southern Medical University, Guangzhou, Guangdong, ChinaDepartment of Nutrition and Food Hygiene, Guangdong Provincial Key Laboratory of Tropical Disease Research, National Medical Products Administration (NMPA) Key Laboratory for Safety Evaluation of Cosmetics, School of Public Health, Southern Medical University, Guangzhou, Guangdong, ChinaDepartment of Clinical Nutrition, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, ChinaDepartment of Nutrition and Food Hygiene, Guangdong Provincial Key Laboratory of Tropical Disease Research, National Medical Products Administration (NMPA) Key Laboratory for Safety Evaluation of Cosmetics, School of Public Health, Southern Medical University, Guangzhou, Guangdong, ChinaMacrophages are innate immune cells present in all tissues and play an important role in almost all aspects of the biology of living organisms. Extracellular vesicles (EVs) are released by cells and transport their contents (micro RNAs, mRNA, proteins, and long noncoding RNAs) to nearby or distant cells for cell-to-cell communication. Numerous studies have shown that macrophage-derived extracellular vesicles (M-EVs) and their contents play an important role in a variety of diseases and show great potential as biomarkers, therapeutics, and drug delivery vehicles for diseases. This article reviews the biological functions and mechanisms of M-EVs and their contents in chronic non-communicable diseases such as cardiovascular diseases, metabolic diseases, cancer, inflammatory diseases and bone-related diseases. In addition, the potential application of M-EVs as drug delivery systems for various diseases have been summarized.https://www.frontiersin.org/articles/10.3389/fimmu.2024.1479330/fullmacrophage-derived extracellular vesiclesexosomesbiological functionsdrug delivery systemschronic non-communicable diseases |
spellingShingle | Fengjuan Lin Huiyu Luo Jiexian Wang Qing Li Longying Zha Macrophage-derived extracellular vesicles as new players in chronic non-communicable diseases Frontiers in Immunology macrophage-derived extracellular vesicles exosomes biological functions drug delivery systems chronic non-communicable diseases |
title | Macrophage-derived extracellular vesicles as new players in chronic non-communicable diseases |
title_full | Macrophage-derived extracellular vesicles as new players in chronic non-communicable diseases |
title_fullStr | Macrophage-derived extracellular vesicles as new players in chronic non-communicable diseases |
title_full_unstemmed | Macrophage-derived extracellular vesicles as new players in chronic non-communicable diseases |
title_short | Macrophage-derived extracellular vesicles as new players in chronic non-communicable diseases |
title_sort | macrophage derived extracellular vesicles as new players in chronic non communicable diseases |
topic | macrophage-derived extracellular vesicles exosomes biological functions drug delivery systems chronic non-communicable diseases |
url | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1479330/full |
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