Macrophage-derived extracellular vesicles as new players in chronic non-communicable diseases

Macrophages are innate immune cells present in all tissues and play an important role in almost all aspects of the biology of living organisms. Extracellular vesicles (EVs) are released by cells and transport their contents (micro RNAs, mRNA, proteins, and long noncoding RNAs) to nearby or distant c...

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Main Authors: Fengjuan Lin, Huiyu Luo, Jiexian Wang, Qing Li, Longying Zha
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Immunology
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1479330/full
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author Fengjuan Lin
Huiyu Luo
Jiexian Wang
Qing Li
Longying Zha
author_facet Fengjuan Lin
Huiyu Luo
Jiexian Wang
Qing Li
Longying Zha
author_sort Fengjuan Lin
collection DOAJ
description Macrophages are innate immune cells present in all tissues and play an important role in almost all aspects of the biology of living organisms. Extracellular vesicles (EVs) are released by cells and transport their contents (micro RNAs, mRNA, proteins, and long noncoding RNAs) to nearby or distant cells for cell-to-cell communication. Numerous studies have shown that macrophage-derived extracellular vesicles (M-EVs) and their contents play an important role in a variety of diseases and show great potential as biomarkers, therapeutics, and drug delivery vehicles for diseases. This article reviews the biological functions and mechanisms of M-EVs and their contents in chronic non-communicable diseases such as cardiovascular diseases, metabolic diseases, cancer, inflammatory diseases and bone-related diseases. In addition, the potential application of M-EVs as drug delivery systems for various diseases have been summarized.
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publisher Frontiers Media S.A.
record_format Article
series Frontiers in Immunology
spelling doaj-art-99b12f502a2b43c4aa6ecdae74f941672025-01-17T05:10:40ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-01-011510.3389/fimmu.2024.14793301479330Macrophage-derived extracellular vesicles as new players in chronic non-communicable diseasesFengjuan Lin0Huiyu Luo1Jiexian Wang2Qing Li3Longying Zha4Department of Nutrition and Food Hygiene, Guangdong Provincial Key Laboratory of Tropical Disease Research, National Medical Products Administration (NMPA) Key Laboratory for Safety Evaluation of Cosmetics, School of Public Health, Southern Medical University, Guangzhou, Guangdong, ChinaDepartment of Nutrition and Food Hygiene, Guangdong Provincial Key Laboratory of Tropical Disease Research, National Medical Products Administration (NMPA) Key Laboratory for Safety Evaluation of Cosmetics, School of Public Health, Southern Medical University, Guangzhou, Guangdong, ChinaDepartment of Nutrition and Food Hygiene, Guangdong Provincial Key Laboratory of Tropical Disease Research, National Medical Products Administration (NMPA) Key Laboratory for Safety Evaluation of Cosmetics, School of Public Health, Southern Medical University, Guangzhou, Guangdong, ChinaDepartment of Clinical Nutrition, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, ChinaDepartment of Nutrition and Food Hygiene, Guangdong Provincial Key Laboratory of Tropical Disease Research, National Medical Products Administration (NMPA) Key Laboratory for Safety Evaluation of Cosmetics, School of Public Health, Southern Medical University, Guangzhou, Guangdong, ChinaMacrophages are innate immune cells present in all tissues and play an important role in almost all aspects of the biology of living organisms. Extracellular vesicles (EVs) are released by cells and transport their contents (micro RNAs, mRNA, proteins, and long noncoding RNAs) to nearby or distant cells for cell-to-cell communication. Numerous studies have shown that macrophage-derived extracellular vesicles (M-EVs) and their contents play an important role in a variety of diseases and show great potential as biomarkers, therapeutics, and drug delivery vehicles for diseases. This article reviews the biological functions and mechanisms of M-EVs and their contents in chronic non-communicable diseases such as cardiovascular diseases, metabolic diseases, cancer, inflammatory diseases and bone-related diseases. In addition, the potential application of M-EVs as drug delivery systems for various diseases have been summarized.https://www.frontiersin.org/articles/10.3389/fimmu.2024.1479330/fullmacrophage-derived extracellular vesiclesexosomesbiological functionsdrug delivery systemschronic non-communicable diseases
spellingShingle Fengjuan Lin
Huiyu Luo
Jiexian Wang
Qing Li
Longying Zha
Macrophage-derived extracellular vesicles as new players in chronic non-communicable diseases
Frontiers in Immunology
macrophage-derived extracellular vesicles
exosomes
biological functions
drug delivery systems
chronic non-communicable diseases
title Macrophage-derived extracellular vesicles as new players in chronic non-communicable diseases
title_full Macrophage-derived extracellular vesicles as new players in chronic non-communicable diseases
title_fullStr Macrophage-derived extracellular vesicles as new players in chronic non-communicable diseases
title_full_unstemmed Macrophage-derived extracellular vesicles as new players in chronic non-communicable diseases
title_short Macrophage-derived extracellular vesicles as new players in chronic non-communicable diseases
title_sort macrophage derived extracellular vesicles as new players in chronic non communicable diseases
topic macrophage-derived extracellular vesicles
exosomes
biological functions
drug delivery systems
chronic non-communicable diseases
url https://www.frontiersin.org/articles/10.3389/fimmu.2024.1479330/full
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AT jiexianwang macrophagederivedextracellularvesiclesasnewplayersinchronicnoncommunicablediseases
AT qingli macrophagederivedextracellularvesiclesasnewplayersinchronicnoncommunicablediseases
AT longyingzha macrophagederivedextracellularvesiclesasnewplayersinchronicnoncommunicablediseases