Bladder recovery by stem cell based cell therapy in the bladder dysfunction induced by spinal cord injury: systematic review and meta-analysis.
<h4>Background</h4>Bladder dysfunction induced by spinal cord injury (SCI) can become problematic and severely impair the quality of life. Preclinical studies of spinal cord injury have largely focused on the recovery of limb function while neglecting to investigate bladder recovery.<...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2015-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0113491 |
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| author | Jae Heon Kim Sung Ryul Shim Seung Whan Doo Won Jae Yang Byung Wook Yoo Joyce Mary Kim Young Myoung Ko Eun Seop Song Ik Sung Lim Hong Jun Lee Yun Seob Song |
| author_facet | Jae Heon Kim Sung Ryul Shim Seung Whan Doo Won Jae Yang Byung Wook Yoo Joyce Mary Kim Young Myoung Ko Eun Seop Song Ik Sung Lim Hong Jun Lee Yun Seob Song |
| author_sort | Jae Heon Kim |
| collection | DOAJ |
| description | <h4>Background</h4>Bladder dysfunction induced by spinal cord injury (SCI) can become problematic and severely impair the quality of life. Preclinical studies of spinal cord injury have largely focused on the recovery of limb function while neglecting to investigate bladder recovery.<h4>Objective</h4>The present study was performed to investigate and review the effect of stem cell-based cell therapy on bladder recovery in SCI.<h4>Methods</h4>We conducted a meta-analysis of urodynamic findings of experimental trials that included studies of stem cell-based cell therapy in SCI. Relevant studies were searched using MEDLINE, EMBASE and Cochrane Library (January 1990 - December 2012). Final inclusion was determined by a urodynamic study involving detailed numerical values. Urodynamic parameters for analysis included voiding pressure, residual urine, bladder capacity and non-voiding contraction (NVC). Meta-analysis of the data, including findings from urodynamic studies, was performed using the Mantel-Haenszel method.<h4>Results</h4>A total of eight studies were included with a sample size of 224 subjects. The studies were divided into different subgroups by different models of SCI. After a stem cell-based cell therapy, voiding pressure (-6.35, p <0.00001, I2 = 77%), NVC (-3.58, p <0.00001, I2 = 82%), residual urine (-024, p = 0.004, I2 = 95%) showed overall significant improvement. Bladder capacity showed improvement after treatment only in the transection type (-0.23, p = 0.0002, I2 = 0%).<h4>Conclusion</h4>After stem cell-based cell therapy in SCI, partial bladder recovery including improvement of voiding pressure, NVC, and residual urine was demonstrated. Additional studies are needed to confirm the detailed mechanism and to obtain an ideal treatment strategy for bladder recovery. |
| format | Article |
| id | doaj-art-99af11d1ebed4486b2525bf29dba47ae |
| institution | DOAJ |
| issn | 1932-6203 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-99af11d1ebed4486b2525bf29dba47ae2025-08-20T03:12:26ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-01103e011349110.1371/journal.pone.0113491Bladder recovery by stem cell based cell therapy in the bladder dysfunction induced by spinal cord injury: systematic review and meta-analysis.Jae Heon KimSung Ryul ShimSeung Whan DooWon Jae YangByung Wook YooJoyce Mary KimYoung Myoung KoEun Seop SongIk Sung LimHong Jun LeeYun Seob Song<h4>Background</h4>Bladder dysfunction induced by spinal cord injury (SCI) can become problematic and severely impair the quality of life. Preclinical studies of spinal cord injury have largely focused on the recovery of limb function while neglecting to investigate bladder recovery.<h4>Objective</h4>The present study was performed to investigate and review the effect of stem cell-based cell therapy on bladder recovery in SCI.<h4>Methods</h4>We conducted a meta-analysis of urodynamic findings of experimental trials that included studies of stem cell-based cell therapy in SCI. Relevant studies were searched using MEDLINE, EMBASE and Cochrane Library (January 1990 - December 2012). Final inclusion was determined by a urodynamic study involving detailed numerical values. Urodynamic parameters for analysis included voiding pressure, residual urine, bladder capacity and non-voiding contraction (NVC). Meta-analysis of the data, including findings from urodynamic studies, was performed using the Mantel-Haenszel method.<h4>Results</h4>A total of eight studies were included with a sample size of 224 subjects. The studies were divided into different subgroups by different models of SCI. After a stem cell-based cell therapy, voiding pressure (-6.35, p <0.00001, I2 = 77%), NVC (-3.58, p <0.00001, I2 = 82%), residual urine (-024, p = 0.004, I2 = 95%) showed overall significant improvement. Bladder capacity showed improvement after treatment only in the transection type (-0.23, p = 0.0002, I2 = 0%).<h4>Conclusion</h4>After stem cell-based cell therapy in SCI, partial bladder recovery including improvement of voiding pressure, NVC, and residual urine was demonstrated. Additional studies are needed to confirm the detailed mechanism and to obtain an ideal treatment strategy for bladder recovery.https://doi.org/10.1371/journal.pone.0113491 |
| spellingShingle | Jae Heon Kim Sung Ryul Shim Seung Whan Doo Won Jae Yang Byung Wook Yoo Joyce Mary Kim Young Myoung Ko Eun Seop Song Ik Sung Lim Hong Jun Lee Yun Seob Song Bladder recovery by stem cell based cell therapy in the bladder dysfunction induced by spinal cord injury: systematic review and meta-analysis. PLoS ONE |
| title | Bladder recovery by stem cell based cell therapy in the bladder dysfunction induced by spinal cord injury: systematic review and meta-analysis. |
| title_full | Bladder recovery by stem cell based cell therapy in the bladder dysfunction induced by spinal cord injury: systematic review and meta-analysis. |
| title_fullStr | Bladder recovery by stem cell based cell therapy in the bladder dysfunction induced by spinal cord injury: systematic review and meta-analysis. |
| title_full_unstemmed | Bladder recovery by stem cell based cell therapy in the bladder dysfunction induced by spinal cord injury: systematic review and meta-analysis. |
| title_short | Bladder recovery by stem cell based cell therapy in the bladder dysfunction induced by spinal cord injury: systematic review and meta-analysis. |
| title_sort | bladder recovery by stem cell based cell therapy in the bladder dysfunction induced by spinal cord injury systematic review and meta analysis |
| url | https://doi.org/10.1371/journal.pone.0113491 |
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