Protocol for developing a mouse model of post-primary pulmonary tuberculosis after hematogenous spread in native lungs and lung implants

Protocol for developing a mouse model of post-primary pulmonary tuberculosis after hematogenous spread in native lungs and lung implants

Summary: Here, we present a protocol for a mouse model for studying mechanisms of post-primary pulmonary tuberculosis (PTB) caused by virulent Mycobacterium tuberculosis (Mtb) using subcutaneous hock infection and lung tissue implantation. We describe steps for collagen instillation of lungs, lung a...

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Bibliographic Details
Main Authors: Shivraj M. Yabaji, Suruchi Lata, Igor Gavrish, Ming Lo, Aoife K. O’Connell, Hans P. Gertje, Colleen E. Thurman, Nicholas A. Crossland, Lester Kobzik, Igor Kramnik
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:STAR Protocols
Subjects:
Immunology
Microbiology
Model Organisms
Online Access:http://www.sciencedirect.com/science/article/pii/S2666166725003909
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