Skin Acute Wound Healing: A Comprehensive Review
Experimental work of the last two decades has revealed the general steps of the wound healing process. This complex network has been organized in three sequential and overlapping steps. The first step of the inflammatory phase is an immediate response to injury; primary sensory neurons sense injury...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2019-01-01
|
| Series: | International Journal of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2019/3706315 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832556119427383296 |
|---|---|
| author | Luis Cañedo-Dorantes Mara Cañedo-Ayala |
| author_facet | Luis Cañedo-Dorantes Mara Cañedo-Ayala |
| author_sort | Luis Cañedo-Dorantes |
| collection | DOAJ |
| description | Experimental work of the last two decades has revealed the general steps of the wound healing process. This complex network has been organized in three sequential and overlapping steps. The first step of the inflammatory phase is an immediate response to injury; primary sensory neurons sense injury and send danger signals to the brain, to stop bleeding and start inflammation. The following target of the inflammatory phase, led by the peripheral blood mononuclear cells, is to eliminate the pathogens and clean the wound. Once this is completed, the inflammatory phase is resolved and homeostasis is restored. The aim of the proliferative phase, the second phase, is to repair wound damage and begin tissue remodeling. Fibroplasia, reepithelialization, angiogenesis, and peripheral nerve repair are the central actions of this phase. Lastly, the objective of the final phase is to complete tissue remodeling and restore skin integrity. This review provides present day information regarding the status of the participant cells, extracellular matrix, cytokines, chemokines, and growth factors, as well as their interactions with the microenvironment during the wound healing process. |
| format | Article |
| id | doaj-art-99a99f87f90c44c698b469a6dc681f3c |
| institution | Kabale University |
| issn | 2090-8040 2042-0099 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Inflammation |
| spelling | doaj-art-99a99f87f90c44c698b469a6dc681f3c2025-02-03T05:46:18ZengWileyInternational Journal of Inflammation2090-80402042-00992019-01-01201910.1155/2019/37063153706315Skin Acute Wound Healing: A Comprehensive ReviewLuis Cañedo-Dorantes0Mara Cañedo-Ayala1Research Division, Faculty of Medicine, Universidad Autónoma del Estado de Morelos, Cuernavaca, Morelos, MexicoIndependent Researcher, Cuernavaca, Morelos, MexicoExperimental work of the last two decades has revealed the general steps of the wound healing process. This complex network has been organized in three sequential and overlapping steps. The first step of the inflammatory phase is an immediate response to injury; primary sensory neurons sense injury and send danger signals to the brain, to stop bleeding and start inflammation. The following target of the inflammatory phase, led by the peripheral blood mononuclear cells, is to eliminate the pathogens and clean the wound. Once this is completed, the inflammatory phase is resolved and homeostasis is restored. The aim of the proliferative phase, the second phase, is to repair wound damage and begin tissue remodeling. Fibroplasia, reepithelialization, angiogenesis, and peripheral nerve repair are the central actions of this phase. Lastly, the objective of the final phase is to complete tissue remodeling and restore skin integrity. This review provides present day information regarding the status of the participant cells, extracellular matrix, cytokines, chemokines, and growth factors, as well as their interactions with the microenvironment during the wound healing process.http://dx.doi.org/10.1155/2019/3706315 |
| spellingShingle | Luis Cañedo-Dorantes Mara Cañedo-Ayala Skin Acute Wound Healing: A Comprehensive Review International Journal of Inflammation |
| title | Skin Acute Wound Healing: A Comprehensive Review |
| title_full | Skin Acute Wound Healing: A Comprehensive Review |
| title_fullStr | Skin Acute Wound Healing: A Comprehensive Review |
| title_full_unstemmed | Skin Acute Wound Healing: A Comprehensive Review |
| title_short | Skin Acute Wound Healing: A Comprehensive Review |
| title_sort | skin acute wound healing a comprehensive review |
| url | http://dx.doi.org/10.1155/2019/3706315 |
| work_keys_str_mv | AT luiscanedodorantes skinacutewoundhealingacomprehensivereview AT maracanedoayala skinacutewoundhealingacomprehensivereview |