The Application of Bioreactors for Cartilage Tissue Engineering: Advances, Limitations, and Future Perspectives
Tissue engineering (TE) has brought new hope for articular cartilage regeneration, as TE can provide structural and functional substitutes for native tissues. The basic elements of TE involve scaffolds, seeded cells, and biochemical and biomechanical stimuli. However, there are some limitations of T...
Saved in:
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021-01-01
|
| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2021/6621806 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832555194437599232 |
|---|---|
| author | Liwei Fu Pinxue Li Hao Li Cangjian Gao Zhen Yang Tianyuan Zhao Wei Chen Zhiyao Liao Yu Peng Fuyang Cao Xiang Sui Shuyun Liu Quanyi Guo |
| author_facet | Liwei Fu Pinxue Li Hao Li Cangjian Gao Zhen Yang Tianyuan Zhao Wei Chen Zhiyao Liao Yu Peng Fuyang Cao Xiang Sui Shuyun Liu Quanyi Guo |
| author_sort | Liwei Fu |
| collection | DOAJ |
| description | Tissue engineering (TE) has brought new hope for articular cartilage regeneration, as TE can provide structural and functional substitutes for native tissues. The basic elements of TE involve scaffolds, seeded cells, and biochemical and biomechanical stimuli. However, there are some limitations of TE; what most important is that static cell culture on scaffolds cannot simulate the physiological environment required for the development of natural cartilage. Recently, bioreactors have been used to simulate the physical and mechanical environment during the development of articular cartilage. This review aims to provide an overview of the concepts, categories, and applications of bioreactors for cartilage TE with emphasis on the design of various bioreactor systems. |
| format | Article |
| id | doaj-art-99a34779786c4264992522f3313e8696 |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-99a34779786c4264992522f3313e86962025-02-03T05:49:26ZengWileyStem Cells International1687-966X1687-96782021-01-01202110.1155/2021/66218066621806The Application of Bioreactors for Cartilage Tissue Engineering: Advances, Limitations, and Future PerspectivesLiwei Fu0Pinxue Li1Hao Li2Cangjian Gao3Zhen Yang4Tianyuan Zhao5Wei Chen6Zhiyao Liao7Yu Peng8Fuyang Cao9Xiang Sui10Shuyun Liu11Quanyi Guo12Institute of Orthopedics, Chinese PLA General Hospital, Beijing Key Laboratory of Regenerative Medicine in Orthopedics, Key Laboratory of Musculoskeletal Trauma & War Injuries PLA, No. 28 Fuxing Road, Haidian District, Beijing 100853, ChinaInstitute of Orthopedics, Chinese PLA General Hospital, Beijing Key Laboratory of Regenerative Medicine in Orthopedics, Key Laboratory of Musculoskeletal Trauma & War Injuries PLA, No. 28 Fuxing Road, Haidian District, Beijing 100853, ChinaInstitute of Orthopedics, Chinese PLA General Hospital, Beijing Key Laboratory of Regenerative Medicine in Orthopedics, Key Laboratory of Musculoskeletal Trauma & War Injuries PLA, No. 28 Fuxing Road, Haidian District, Beijing 100853, ChinaInstitute of Orthopedics, Chinese PLA General Hospital, Beijing Key Laboratory of Regenerative Medicine in Orthopedics, Key Laboratory of Musculoskeletal Trauma & War Injuries PLA, No. 28 Fuxing Road, Haidian District, Beijing 100853, ChinaInstitute of Orthopedics, Chinese PLA General Hospital, Beijing Key Laboratory of Regenerative Medicine in Orthopedics, Key Laboratory of Musculoskeletal Trauma & War Injuries PLA, No. 28 Fuxing Road, Haidian District, Beijing 100853, ChinaInstitute of Orthopedics, Chinese PLA General Hospital, Beijing Key Laboratory of Regenerative Medicine in Orthopedics, Key Laboratory of Musculoskeletal Trauma & War Injuries PLA, No. 28 Fuxing Road, Haidian District, Beijing 100853, ChinaInstitute of Orthopedics, Chinese PLA General Hospital, Beijing Key Laboratory of Regenerative Medicine in Orthopedics, Key Laboratory of Musculoskeletal Trauma & War Injuries PLA, No. 28 Fuxing Road, Haidian District, Beijing 100853, ChinaInstitute of Orthopedics, Chinese PLA General Hospital, Beijing Key Laboratory of Regenerative Medicine in Orthopedics, Key Laboratory of Musculoskeletal Trauma & War Injuries PLA, No. 28 Fuxing Road, Haidian District, Beijing 100853, ChinaSchool of Medicine, Nankai University, Tianjin 300071, ChinaInstitute of Orthopedics, Chinese PLA General Hospital, Beijing Key Laboratory of Regenerative Medicine in Orthopedics, Key Laboratory of Musculoskeletal Trauma & War Injuries PLA, No. 28 Fuxing Road, Haidian District, Beijing 100853, ChinaInstitute of Orthopedics, Chinese PLA General Hospital, Beijing Key Laboratory of Regenerative Medicine in Orthopedics, Key Laboratory of Musculoskeletal Trauma & War Injuries PLA, No. 28 Fuxing Road, Haidian District, Beijing 100853, ChinaInstitute of Orthopedics, Chinese PLA General Hospital, Beijing Key Laboratory of Regenerative Medicine in Orthopedics, Key Laboratory of Musculoskeletal Trauma & War Injuries PLA, No. 28 Fuxing Road, Haidian District, Beijing 100853, ChinaInstitute of Orthopedics, Chinese PLA General Hospital, Beijing Key Laboratory of Regenerative Medicine in Orthopedics, Key Laboratory of Musculoskeletal Trauma & War Injuries PLA, No. 28 Fuxing Road, Haidian District, Beijing 100853, ChinaTissue engineering (TE) has brought new hope for articular cartilage regeneration, as TE can provide structural and functional substitutes for native tissues. The basic elements of TE involve scaffolds, seeded cells, and biochemical and biomechanical stimuli. However, there are some limitations of TE; what most important is that static cell culture on scaffolds cannot simulate the physiological environment required for the development of natural cartilage. Recently, bioreactors have been used to simulate the physical and mechanical environment during the development of articular cartilage. This review aims to provide an overview of the concepts, categories, and applications of bioreactors for cartilage TE with emphasis on the design of various bioreactor systems.http://dx.doi.org/10.1155/2021/6621806 |
| spellingShingle | Liwei Fu Pinxue Li Hao Li Cangjian Gao Zhen Yang Tianyuan Zhao Wei Chen Zhiyao Liao Yu Peng Fuyang Cao Xiang Sui Shuyun Liu Quanyi Guo The Application of Bioreactors for Cartilage Tissue Engineering: Advances, Limitations, and Future Perspectives Stem Cells International |
| title | The Application of Bioreactors for Cartilage Tissue Engineering: Advances, Limitations, and Future Perspectives |
| title_full | The Application of Bioreactors for Cartilage Tissue Engineering: Advances, Limitations, and Future Perspectives |
| title_fullStr | The Application of Bioreactors for Cartilage Tissue Engineering: Advances, Limitations, and Future Perspectives |
| title_full_unstemmed | The Application of Bioreactors for Cartilage Tissue Engineering: Advances, Limitations, and Future Perspectives |
| title_short | The Application of Bioreactors for Cartilage Tissue Engineering: Advances, Limitations, and Future Perspectives |
| title_sort | application of bioreactors for cartilage tissue engineering advances limitations and future perspectives |
| url | http://dx.doi.org/10.1155/2021/6621806 |
| work_keys_str_mv | AT liweifu theapplicationofbioreactorsforcartilagetissueengineeringadvanceslimitationsandfutureperspectives AT pinxueli theapplicationofbioreactorsforcartilagetissueengineeringadvanceslimitationsandfutureperspectives AT haoli theapplicationofbioreactorsforcartilagetissueengineeringadvanceslimitationsandfutureperspectives AT cangjiangao theapplicationofbioreactorsforcartilagetissueengineeringadvanceslimitationsandfutureperspectives AT zhenyang theapplicationofbioreactorsforcartilagetissueengineeringadvanceslimitationsandfutureperspectives AT tianyuanzhao theapplicationofbioreactorsforcartilagetissueengineeringadvanceslimitationsandfutureperspectives AT weichen theapplicationofbioreactorsforcartilagetissueengineeringadvanceslimitationsandfutureperspectives AT zhiyaoliao theapplicationofbioreactorsforcartilagetissueengineeringadvanceslimitationsandfutureperspectives AT yupeng theapplicationofbioreactorsforcartilagetissueengineeringadvanceslimitationsandfutureperspectives AT fuyangcao theapplicationofbioreactorsforcartilagetissueengineeringadvanceslimitationsandfutureperspectives AT xiangsui theapplicationofbioreactorsforcartilagetissueengineeringadvanceslimitationsandfutureperspectives AT shuyunliu theapplicationofbioreactorsforcartilagetissueengineeringadvanceslimitationsandfutureperspectives AT quanyiguo theapplicationofbioreactorsforcartilagetissueengineeringadvanceslimitationsandfutureperspectives AT liweifu applicationofbioreactorsforcartilagetissueengineeringadvanceslimitationsandfutureperspectives AT pinxueli applicationofbioreactorsforcartilagetissueengineeringadvanceslimitationsandfutureperspectives AT haoli applicationofbioreactorsforcartilagetissueengineeringadvanceslimitationsandfutureperspectives AT cangjiangao applicationofbioreactorsforcartilagetissueengineeringadvanceslimitationsandfutureperspectives AT zhenyang applicationofbioreactorsforcartilagetissueengineeringadvanceslimitationsandfutureperspectives AT tianyuanzhao applicationofbioreactorsforcartilagetissueengineeringadvanceslimitationsandfutureperspectives AT weichen applicationofbioreactorsforcartilagetissueengineeringadvanceslimitationsandfutureperspectives AT zhiyaoliao applicationofbioreactorsforcartilagetissueengineeringadvanceslimitationsandfutureperspectives AT yupeng applicationofbioreactorsforcartilagetissueengineeringadvanceslimitationsandfutureperspectives AT fuyangcao applicationofbioreactorsforcartilagetissueengineeringadvanceslimitationsandfutureperspectives AT xiangsui applicationofbioreactorsforcartilagetissueengineeringadvanceslimitationsandfutureperspectives AT shuyunliu applicationofbioreactorsforcartilagetissueengineeringadvanceslimitationsandfutureperspectives AT quanyiguo applicationofbioreactorsforcartilagetissueengineeringadvanceslimitationsandfutureperspectives |