The role of n-3-derived specialised pro-resolving mediators (SPMs) in microglial mitochondrial respiration and inflammation resolution in Alzheimer’s disease

Abstract Alzheimer’s disease (AD) is the most common form of dementia globally and is characterised by reduced mitochondrial respiration and cortical deposition of amyloid-β plaques and neurofibrillary tangles comprised of hyper-phosphorylated tau. Despite its characterisation more than 110 years ag...

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Bibliographic Details
Main Authors: Mary Slayo, Christoph Rummel, Pasindu Hansana Singhaarachchi, Martin Feldotto, Sarah J. Spencer
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Molecular Neurodegeneration
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Online Access:https://doi.org/10.1186/s13024-025-00824-1
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