Evaluation of corneal epithelial mapping in type-2 diabetes mellitus
Aim To quantify corneal epithelial changes in type-2 diabetic patients (DM-2) using anterior-segment optical coherence tomography (AS-OCT). Setting BADR University Hospital, and Al-Mashreq Eye Center, Cairo, Egypt. Patients and methods A prospective, comparative study that included, total 96 eyes: 4...
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Wolters Kluwer Medknow Publications
2025-04-01
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| Series: | Journal of the Egyptian Ophthalmological Society |
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| Online Access: | https://journals.lww.com/10.4103/ejos.ejos_55_24 |
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| author | Esraa R. Hassaan Mostafa M. Bahgat Ahmed F. El-Shahed |
| author_facet | Esraa R. Hassaan Mostafa M. Bahgat Ahmed F. El-Shahed |
| author_sort | Esraa R. Hassaan |
| collection | DOAJ |
| description | Aim
To quantify corneal epithelial changes in type-2 diabetic patients (DM-2) using anterior-segment optical coherence tomography (AS-OCT).
Setting
BADR University Hospital, and Al-Mashreq Eye Center, Cairo, Egypt.
Patients and methods
A prospective, comparative study that included, total 96 eyes: 48 eyes of 24 DM-2 patients, and 48 eyes of 24 healthy participants. Diabetic cases were sub-divided into controlled, and uncontrolled groups. All participants were recruited and underwent standard clinical examination and testing including history taking, a detailed ophthalmic examination, and lab investigation. AS-OCT was used to evaluate corneal epithelial thickness (using OptoVue, AS-OCT).
Results
The mean duration of diabetes in all studied patients was 16.1±6.9 (0.17–30) years. There were 16 (66.7%) controlled patients and eight (33.3%) uncontrolled patients in the patient’s group. Clinical data showed a high statistically significant (P<0.001) decreased best-corrected visual acuity in patient’s group. No statistically significant difference (P=0.979) between studied groups as regards intraocular pressure.
At 5 mm zone, the patient’s group showed a high statistically significant (P<0.001) decrease in superior corneal epithelium and superio-temporal corneal epithelium. Also, there was a statistically significant decrease in temporal corneal epithelium (P=0.008), and superio-nasal corneal epithelium (P=0.019). While at 7 mm zone, high statistically significant (P<0.001) decrease in superior, Superio-temporal, inferior, and Infero-nasal corneal epithelium in patient’s group. Also, a statistically significant decrease in temporal corneal epithelium (P=0.017) and superio-nasal corneal epithelium (P=0.002) was noted in patient’s group. In the patient’s group, there was no statistically significant (P>0.05) correlation between DM duration and corneal epithelial mapping in both 5 mm and 7 mm. no statistically significant (P>0.05) correlation between DM severity and corneal epithelial mapping, however there was a statistically significant (P=0.008) decreased corneal epithelium in uncontrolled patients in infero-nasal cornea (P=0.008), and Infero-temporal cornea (P=0.041) at 7 mm zone.
Conclusion
AS-OCT is a noninvasive and highly effective procedure in early detection of corneal epithelium abnormalities. DM-2 has a significant effect on the corneal epithelial thickness. |
| format | Article |
| id | doaj-art-9997ac99f015485aa2e5143af7b20b98 |
| institution | Kabale University |
| issn | 2090-0686 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of the Egyptian Ophthalmological Society |
| spelling | doaj-art-9997ac99f015485aa2e5143af7b20b982025-08-20T03:52:52ZengWolters Kluwer Medknow PublicationsJournal of the Egyptian Ophthalmological Society2090-06862025-04-01118215015810.4103/ejos.ejos_55_24Evaluation of corneal epithelial mapping in type-2 diabetes mellitusEsraa R. HassaanMostafa M. BahgatAhmed F. El-ShahedAim To quantify corneal epithelial changes in type-2 diabetic patients (DM-2) using anterior-segment optical coherence tomography (AS-OCT). Setting BADR University Hospital, and Al-Mashreq Eye Center, Cairo, Egypt. Patients and methods A prospective, comparative study that included, total 96 eyes: 48 eyes of 24 DM-2 patients, and 48 eyes of 24 healthy participants. Diabetic cases were sub-divided into controlled, and uncontrolled groups. All participants were recruited and underwent standard clinical examination and testing including history taking, a detailed ophthalmic examination, and lab investigation. AS-OCT was used to evaluate corneal epithelial thickness (using OptoVue, AS-OCT). Results The mean duration of diabetes in all studied patients was 16.1±6.9 (0.17–30) years. There were 16 (66.7%) controlled patients and eight (33.3%) uncontrolled patients in the patient’s group. Clinical data showed a high statistically significant (P<0.001) decreased best-corrected visual acuity in patient’s group. No statistically significant difference (P=0.979) between studied groups as regards intraocular pressure. At 5 mm zone, the patient’s group showed a high statistically significant (P<0.001) decrease in superior corneal epithelium and superio-temporal corneal epithelium. Also, there was a statistically significant decrease in temporal corneal epithelium (P=0.008), and superio-nasal corneal epithelium (P=0.019). While at 7 mm zone, high statistically significant (P<0.001) decrease in superior, Superio-temporal, inferior, and Infero-nasal corneal epithelium in patient’s group. Also, a statistically significant decrease in temporal corneal epithelium (P=0.017) and superio-nasal corneal epithelium (P=0.002) was noted in patient’s group. In the patient’s group, there was no statistically significant (P>0.05) correlation between DM duration and corneal epithelial mapping in both 5 mm and 7 mm. no statistically significant (P>0.05) correlation between DM severity and corneal epithelial mapping, however there was a statistically significant (P=0.008) decreased corneal epithelium in uncontrolled patients in infero-nasal cornea (P=0.008), and Infero-temporal cornea (P=0.041) at 7 mm zone. Conclusion AS-OCT is a noninvasive and highly effective procedure in early detection of corneal epithelium abnormalities. DM-2 has a significant effect on the corneal epithelial thickness.https://journals.lww.com/10.4103/ejos.ejos_55_24anterior-segment optical coherence tomographycorneal epithelial mappingdiabetes mellitustype 2 diabetes mellitus |
| spellingShingle | Esraa R. Hassaan Mostafa M. Bahgat Ahmed F. El-Shahed Evaluation of corneal epithelial mapping in type-2 diabetes mellitus Journal of the Egyptian Ophthalmological Society anterior-segment optical coherence tomography corneal epithelial mapping diabetes mellitus type 2 diabetes mellitus |
| title | Evaluation of corneal epithelial mapping in type-2 diabetes mellitus |
| title_full | Evaluation of corneal epithelial mapping in type-2 diabetes mellitus |
| title_fullStr | Evaluation of corneal epithelial mapping in type-2 diabetes mellitus |
| title_full_unstemmed | Evaluation of corneal epithelial mapping in type-2 diabetes mellitus |
| title_short | Evaluation of corneal epithelial mapping in type-2 diabetes mellitus |
| title_sort | evaluation of corneal epithelial mapping in type 2 diabetes mellitus |
| topic | anterior-segment optical coherence tomography corneal epithelial mapping diabetes mellitus type 2 diabetes mellitus |
| url | https://journals.lww.com/10.4103/ejos.ejos_55_24 |
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