Lipid Profile in Adolescent Girls with Type 1 Diabetes Mellitus and Hyperandrogenemia
Study Objectives. The study aim was to evaluate whether hyperandrogenemia in adolescent girls with type 1 diabetes mellitus (T1DM) may adversely influence lipid profile. Design and Participants. Lipid levels in 16 diabetic girls with biochemical hyperandrogenemia (T1DM-H) aged 16.3 ± 1.2 years were...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2016/9473158 |
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| author | Agnieszka Zachurzok Grazyna Deja Aneta Gawlik Agnieszka Drosdzol-Cop Katarzyna Klimek Ewa Malecka-Tendera |
| author_facet | Agnieszka Zachurzok Grazyna Deja Aneta Gawlik Agnieszka Drosdzol-Cop Katarzyna Klimek Ewa Malecka-Tendera |
| author_sort | Agnieszka Zachurzok |
| collection | DOAJ |
| description | Study Objectives. The study aim was to evaluate whether hyperandrogenemia in adolescent girls with type 1 diabetes mellitus (T1DM) may adversely influence lipid profile. Design and Participants. Lipid levels in 16 diabetic girls with biochemical hyperandrogenemia (T1DM-H) aged 16.3 ± 1.2 years were compared to 38 diabetic girls with normal androgen levels (T1DM-N) aged 15.8 ± 1.2 years. 15 healthy girls served as controls (CG). In all patients, anthropometric measurements were done, and androgens and SHBG were assessed. Results. In T1DM-H, total cholesterol (TC) and low density cholesterol (LDL-ch) were significantly higher than in CG (196.1 ± 41.2 versus 162.7 ± 31.7 mg/dL, p=0.01; 117.3 ± 33.1 versus 91.3 ± 27.8 mg/dL, p=0.01, resp.). Their LDL-ch, non-high density cholesterol (non-HDL-ch) concentrations, and LDL/HDL ratio were also significantly higher than in T1DM-N (117.3 ± 33.1 versus 97.7 ± 26.7 mg/dL, p=0.03; 137.3 ± 42.9 versus 113.3 ± 40.4 mg/dL, p=0.04; 2.8 ± 3.7 versus 1.6 ± 0.5, p=0.04, resp.). In stepwise multiple linear regression, free androgen index (FAI) and waist-to-hip ratio (WHR) were associated with TC (R2=0.4, p<0.0006), non-HDL-ch (R2=0.4, p<0.0003), and LDL-ch (R2=0.4, p<0.0008). Triglycerides and LDL/HDL ratio were (R2=0.7, p<0.0001, R2=0.6, p<0.0003 resp.) related to testosterone, FAI, WHR, and mean HbA1c. Conclusion. Lipid profile in diabetic adolescent girls is adversely influenced by the androgens level, particularly in the group with higher WHR and poorer glycemic control. |
| format | Article |
| id | doaj-art-9994cfbca9124f2ca1c1582ce0deeaa0 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-9994cfbca9124f2ca1c1582ce0deeaa02025-02-03T01:00:26ZengWileyInternational Journal of Endocrinology1687-83371687-83452016-01-01201610.1155/2016/94731589473158Lipid Profile in Adolescent Girls with Type 1 Diabetes Mellitus and HyperandrogenemiaAgnieszka Zachurzok0Grazyna Deja1Aneta Gawlik2Agnieszka Drosdzol-Cop3Katarzyna Klimek4Ewa Malecka-Tendera5Department of Pediatrics and Pediatric Endocrinology, School of Medicine in Katowice, Medical University of Silesia, Medykow Street 16, 40-752 Katowice, PolandDepartment of Pediatric Diabetes, School of Medicine in Katowice, Medical University of Silesia, Medykow Street 16, 40-752 Katowice, PolandDepartment of Pediatrics and Pediatric Endocrinology, School of Medicine in Katowice, Medical University of Silesia, Medykow Street 16, 40-752 Katowice, PolandDepartment of Woman’s Health, School of Medicine in Katowice, Medical University of Silesia, Medykow Street 12, 40-752 Katowice, PolandDepartment of Instrumental Analysis, School of Pharmacy in Sosnowiec, Medical University of Silesia, Jednosci Street 8, 41-200 Sosnowiec, PolandDepartment of Pediatrics and Pediatric Endocrinology, School of Medicine in Katowice, Medical University of Silesia, Medykow Street 16, 40-752 Katowice, PolandStudy Objectives. The study aim was to evaluate whether hyperandrogenemia in adolescent girls with type 1 diabetes mellitus (T1DM) may adversely influence lipid profile. Design and Participants. Lipid levels in 16 diabetic girls with biochemical hyperandrogenemia (T1DM-H) aged 16.3 ± 1.2 years were compared to 38 diabetic girls with normal androgen levels (T1DM-N) aged 15.8 ± 1.2 years. 15 healthy girls served as controls (CG). In all patients, anthropometric measurements were done, and androgens and SHBG were assessed. Results. In T1DM-H, total cholesterol (TC) and low density cholesterol (LDL-ch) were significantly higher than in CG (196.1 ± 41.2 versus 162.7 ± 31.7 mg/dL, p=0.01; 117.3 ± 33.1 versus 91.3 ± 27.8 mg/dL, p=0.01, resp.). Their LDL-ch, non-high density cholesterol (non-HDL-ch) concentrations, and LDL/HDL ratio were also significantly higher than in T1DM-N (117.3 ± 33.1 versus 97.7 ± 26.7 mg/dL, p=0.03; 137.3 ± 42.9 versus 113.3 ± 40.4 mg/dL, p=0.04; 2.8 ± 3.7 versus 1.6 ± 0.5, p=0.04, resp.). In stepwise multiple linear regression, free androgen index (FAI) and waist-to-hip ratio (WHR) were associated with TC (R2=0.4, p<0.0006), non-HDL-ch (R2=0.4, p<0.0003), and LDL-ch (R2=0.4, p<0.0008). Triglycerides and LDL/HDL ratio were (R2=0.7, p<0.0001, R2=0.6, p<0.0003 resp.) related to testosterone, FAI, WHR, and mean HbA1c. Conclusion. Lipid profile in diabetic adolescent girls is adversely influenced by the androgens level, particularly in the group with higher WHR and poorer glycemic control.http://dx.doi.org/10.1155/2016/9473158 |
| spellingShingle | Agnieszka Zachurzok Grazyna Deja Aneta Gawlik Agnieszka Drosdzol-Cop Katarzyna Klimek Ewa Malecka-Tendera Lipid Profile in Adolescent Girls with Type 1 Diabetes Mellitus and Hyperandrogenemia International Journal of Endocrinology |
| title | Lipid Profile in Adolescent Girls with Type 1 Diabetes Mellitus and Hyperandrogenemia |
| title_full | Lipid Profile in Adolescent Girls with Type 1 Diabetes Mellitus and Hyperandrogenemia |
| title_fullStr | Lipid Profile in Adolescent Girls with Type 1 Diabetes Mellitus and Hyperandrogenemia |
| title_full_unstemmed | Lipid Profile in Adolescent Girls with Type 1 Diabetes Mellitus and Hyperandrogenemia |
| title_short | Lipid Profile in Adolescent Girls with Type 1 Diabetes Mellitus and Hyperandrogenemia |
| title_sort | lipid profile in adolescent girls with type 1 diabetes mellitus and hyperandrogenemia |
| url | http://dx.doi.org/10.1155/2016/9473158 |
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